FISH for t(14;18) - Follicular Lymphoma - Price, Normal Range | Sprint Diagnostics Hyderabad
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Follicular lymphoma is one of the most common types of non-Hodgkin's lymphoma and is characterized by the slow-growing presence of cancerous cells in the lymph system. One of the defining features of follicular lymphoma is a chromosomal translocation between chromosomes 14 and 18, known as t(14;18). This translocation results in the juxtaposition of the immunoglobulin heavy chain gene (IGH) on chromosome 14 to the BCL2 gene on chromosome 18. As a consequence, there is an overexpression of the BCL2 protein which prevents the normal process of cell death, allowing the lymphoma cells to survive and accumulate.
Fluorescence in situ hybridization, commonly known as FISH, is a test that is used to visualize and map the genetic material in an individual's cells, including the chromosomes. The FISH test for t(14;18) is particularly used in the diagnosis of follicular lymphoma, helping in not only confirming the disease but also in evaluating prognosis and guiding treatment decisions.
|FISH for t(14;18) - Follicular Lymphoma
|Blood or Tissue Sample
|No specific preparation is required.
|Price in Hyderabad
What is the FISH test for t(14;18)?
FISH for t(14;18) is a diagnostic test that uses fluorescent probes to detect the chromosomal translocation between chromosomes 14 and 18, which is characteristic of follicular lymphoma. This test helps in the diagnosis and management of the disease.
Why is the FISH for t(14;18) test done?
The FISH test for t(14;18) is performed to confirm the diagnosis of follicular lymphoma. It helps to differentiate follicular lymphoma from other types of lymphoma, which is essential for determining the appropriate treatment and evaluating the prognosis.
Home Sample Collection
How is the sample collected for this test?
For FISH testing, a blood sample is usually collected from a vein in the arm. In some cases, a tissue sample from a lymph node may be required, which is collected through a biopsy procedure.
Who should undergo the FISH for t(14;18) test?
Individuals who have symptoms of lymphoma, such as swollen lymph nodes, fatigue, or unexplained weight loss, and are suspected to have follicular lymphoma based on initial assessments, should undergo this test.
What does a positive result for t(14;18) indicate?
A positive result indicates the presence of the chromosomal translocation t(14;18), which is characteristic of follicular lymphoma. This helps in confirming the diagnosis and can have implications on treatment decisions.
Can the FISH test for t(14;18) be used to monitor treatment response?
Yes, the FISH test can be used to monitor the response to treatment in patients with follicular lymphoma. The reduction in cells with the t(14;18) translocation can indicate a positive response to therapy.
What are the treatment options for follicular lymphoma?
Treatment options for follicular lymphoma include chemotherapy, radiation therapy, immunotherapy, and targeted drug therapy. The treatment is selected based on the stage and progression of the disease, and the patient’s overall health.
Is follicular lymphoma curable?
Follicular lymphoma is considered a chronic disease that can be managed but is not usually curable with standard treatments. However, long-term remission is possible for some patients.
Are there any risk factors associated with follicular lymphoma?
Risk factors for follicular lymphoma include age, as the disease is more common in older adults, and a family history of lymphoma. Exposure to radiation or chemicals may also be risk factors.
How can I improve my prognosis if diagnosed with follicular lymphoma?
Following the treatment plan recommended by your doctor, maintaining a healthy lifestyle, staying active, and regularly monitoring the disease with your doctor can improve prognosis.
Can the FISH test for t(14;18) predict the aggressiveness of the follicular lymphoma?
Yes, the number of cells with t(14;18) translocation can provide information on the aggressiveness of the disease and can be used for risk stratification.
Is there any dietary recommendation for patients with follicular lymphoma?
A balanced diet, rich in fruits, vegetables, and whole grains, can help to improve the overall health of patients with follicular lymphoma. It is also advisable to discuss dietary choices with your doctor.
What are the side effects of the FISH test?
There are minimal risks associated with the blood draw for the FISH test. However, for a biopsy, there is a small risk of infection, bleeding, or bruising at the biopsy site.
What kind of doctor should I consult if I am diagnosed with follicular lymphoma?
If you are diagnosed with follicular lymphoma, it is advisable to consult a hematologist or oncologist who specializes in the treatment of blood cancers.
Are there new treatments being developed for follicular lymphoma?
Yes, research is ongoing, and new treatments including targeted therapies and immunotherapies are being developed for follicular lymphoma.
Follicular lymphoma is a complex disease that requires careful diagnosis and management. Understanding the importance of genetic testing in the diagnosis, such as the FISH for t(14;18), is critical. This test is instrumental in confirming the diagnosis, assessing the aggressiveness of the disease, and monitoring the response to treatment. Being well-informed and maintaining open communication with your doctor are essential components in the management of follicular lymphoma.
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