FISH for t(11;14) - Mantle Cell Lymphoma - Price, Normal Range | Sprint Diagnostics Hyderabad

Patient Preparing : No specific preparation is required.

₹ 4500


Mantle Cell Lymphoma (MCL) is a type of non-Hodgkin lymphoma, characterized by the abnormal proliferation of B-lymphocytes, which are a type of white blood cell. The FISH (Fluorescence In Situ Hybridization) test for t(11;14) is a diagnostic procedure utilized to detect a specific chromosomal translocation between chromosome 11 and 14, which is a hallmark of MCL. This translocation leads to the overexpression of the cyclin D1 gene, promoting the uncontrolled division of B-lymphocytes.

Identifying t(11;14) is crucial for the accurate diagnosis of MCL, as it differentiates it from other lymphomas. The detection of this translocation also has prognostic implications and may guide therapeutic strategies.

Test Name FISH for t(11;14) - Mantle Cell Lymphoma
Sample Type Bone Marrow or Blood or Tissue Sample
Preparations Required No specific preparation is required.
Report Time 5 days
Price in Hyderabad ₹ 4500

Why is the FISH for t(11;14) test done?

FISH for t(11;14) is performed to confirm the diagnosis of Mantle Cell Lymphoma (MCL). It helps to differentiate MCL from other types of lymphoma, which is essential for determining the appropriate treatment.

What does the presence of t(11;14) indicate?

The presence of t(11;14) indicates a chromosomal abnormality that is characteristic of Mantle Cell Lymphoma. This translocation leads to the overexpression of the cyclin D1 gene, which is involved in cell cycle regulation, and contributes to the uncontrolled growth of lymphocytes.

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How is the sample for the FISH test collected?

For FISH testing, a blood sample is usually collected from a vein in the arm. Sometimes, a tissue sample from a lymph node or other tissue may be needed, which is collected through a biopsy procedure.

Does the test require any special preparation?

No special preparation is needed before the test. You can eat and drink normally and continue with your regular medications unless instructed otherwise by your doctor.

Can the FISH for t(11;14) test be used to monitor treatment?

Yes, the FISH test can be used to monitor the response to treatment in patients with MCL. The reduction in cells with the t(11;14) translocation can indicate a positive response to therapy.

What treatment options are available for patients with MCL?

Treatment options for MCL include chemotherapy, targeted therapy, radiation therapy, stem cell transplantation, and immunotherapy. The choice of treatment depends on various factors including the stage of the disease, the patient’s health, and the genetic characteristics of the tumor.

What are the symptoms of Mantle Cell Lymphoma?

Symptoms of MCL may include swollen lymph nodes, fatigue, night sweats, unexplained weight loss, and frequent infections.

Is Mantle Cell Lymphoma curable?

MCL is generally considered a treatable but incurable cancer. However, some patients can achieve long-term remission with appropriate therapy.

How is Mantle Cell Lymphoma different from other types of lymphoma?

MCL is different from other lymphomas mainly due to the presence of the t(11;14) translocation. It also has a distinct pattern of lymph node involvement and typically has a more aggressive course compared to some other types of lymphoma.

Can Mantle Cell Lymphoma recur after treatment?

Yes, MCL can recur after treatment. This is known as relapse. In such cases, alternative treatment regimens may be considered.

Are there any risk factors for developing MCL?

The risk factors for developing MCL are not well-defined. However, it is more common in older adults and affects more men than women.

How often should I be tested for t(11;14) if I have MCL?

The frequency of testing depends on various factors including the stage of the disease and the type of treatment. Your doctor will provide guidance on how often the test should be performed.

Are there any side effects or risks associated with the FISH test for t(11;14)?

There are minimal risks associated with blood collection. For tissue biopsies, there may be risks such as infection or bleeding, but these are generally rare.

What should I do if my test results show the t(11;14) translocation?

If your test results show the t(11;14) translocation, it is important to consult a doctor specializing in hematology or oncology. They will guide you on the appropriate treatment options and monitoring.

Are there ongoing research or clinical trials for MCL?

Yes, there are ongoing research and clinical trials for new treatments for MCL, including targeted therapies and immunotherapies.

The FISH for t(11;14) test is an important diagnostic tool in the management of Mantle Cell Lymphoma. It is essential for accurate diagnosis and can have implications for prognosis and treatment. If you or someone you know is undergoing evaluation for lymphoma, understanding the role of genetic testing in diagnosis and management is important. Please discuss any concerns or questions with your doctor to make informed decisions regarding your healthcare.

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