FISH for t(10;24) HOX11

FISH for t(10;24) HOX11

FISH, or Fluorescence In Situ Hybridization, is a molecular diagnostic technique that uses fluorescent probes to detect specific DNA sequences on chromosomes. The t(10;24) translocation involves a rearrangement between chromosomes 10 and 24 and is associated with certain types of cancers, specifically some T-cell acute lymphoblastic leukemias (T-ALL). This translocation leads to the aberrant expression of the HOX11 gene, which is believed to contribute to the development of leukemia.

In patients with T-ALL, the FISH for t(10;24) HOX11 helps to detect this specific chromosomal abnormality. The presence of the t(10;24) translocation can have prognostic implications and may guide treatment decisions.

  • Test NameFISH for t(10;24) HOX11
  • Sample TypeBlood or Bone Marrow
  • Preparations RequiredNo specific preparation is required.
  • Report Time12 days

Why is the FISH for t(10;24) HOX11 test important?

The FISH for t(10;24) HOX11 is important as it helps in the diagnosis and classification of certain leukemias, particularly T-cell acute lymphoblastic leukemia. Identifying this specific chromosomal translocation can provide information on prognosis and help in making treatment decisions.

What does it mean if the t(10;24) translocation is present?

If the t(10;24) translocation is present, it indicates that there has been a chromosomal rearrangement involving the HOX11 gene. This is associated with certain types of leukemia and suggests that the HOX11 gene may be playing a role in the development of the cancer.

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Sample Collection by Phlebotomist
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Reporting of the sample at lab
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Frequently Asked Questions

The test is usually performed on a blood sample or bone marrow aspirate. A healthcare professional will collect the sample by drawing blood from a vein or by performing a bone marrow aspiration.

No special preparation is needed for this test. Patients do not need to fast and there are no restrictions on water consumption or medications before the test.

The risks associated with the FISH for t(10;24) HOX11 are primarily related to the sample collection. Blood collection is generally low risk, but bone marrow aspiration can cause discomfort, bruising, or infection at the site of the procedure.

Other tests that might be performed along with this FISH test include complete blood count, immunophenotyping, cytogenetic analysis, and other molecular genetic tests to evaluate for additional chromosomal abnormalities.

Yes, this test can be used to monitor response to treatment in patients with leukemia. A decrease in cells with the t(10;24) translocation after treatment may indicate a positive response.

The results of this test can help in determining the prognosis and guiding treatment options for patients with leukemia. It can also be used to monitor the response to treatment and to detect residual disease.

If the test indicates the presence of the t(10;24) translocation, it is advisable to consult an oncologist or a hematologist who specializes in the treatment of leukemia.

The t(10;24) translocation is relatively rare compared to other chromosomal abnormalities in leukemia.

Technical factors such as the quality of the sample can affect the results. It’s also possible that a very low percentage of cells with the t(10;24) translocation may not be detected.

The prognosis and treatment of leukemia with the t(10;24) translocation can vary. Some patients may achieve remission with chemotherapy, while others may require more aggressive treatments such as stem cell transplantation.

Most cases of leukemia are sporadic, but certain inherited genetic disorders and family history can increase the risk.

Treatment options for patients with T-cell acute lymphoblastic leukemia with the t(10;24) translocation include chemotherapy, radiation therapy, targeted therapies, and stem cell transplantation.

Research is ongoing into new treatments for leukemia. This includes the development of targeted therapies that specifically attack cancer cells with certain genetic changes, such as the t(10;24) translocation.

FISH for t(10;24) HOX11 is an essential diagnostic tool in the management of certain types of leukemia. By detecting specific chromosomal changes, this test can provide important information that helps doctors to make informed decisions regarding prognosis and treatment. If you or a loved one has been diagnosed with leukemia or are undergoing evaluation for possible leukemia, it’s important to discuss the role that genetic testing, including FISH for t(10;24) HOX11, can play in the management of the condition with a doctor.

FISH for t (10:24) HOX11
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