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FISH for Synovial Sarcoma

FISH for Synovial Sarcoma

Synovial sarcoma is a rare type of cancer that typically arises near the joints of the arms, legs, or trunk, but can occur in other areas. Despite its name, it does not arise from synovial cells but rather from pluripotent stem cells. FISH, which stands for Fluorescence In Situ Hybridization, for synovial sarcoma is a diagnostic test used to detect specific chromosomal translocations that are characteristic of this type of cancer. The most common translocation in synovial sarcoma involves the fusion of the SYT gene on chromosome 18 and the SSX gene on chromosome X.

FISH uses fluorescent probes that specifically attach to the SYT and SSX genes. Under a fluorescent microscope, if these probes are in close proximity or appear fused, this suggests the presence of the characteristic chromosomal translocation of synovial sarcoma.


  • Test NameFISH for Synovial Sarcoma
  • Sample TypeTissue
  • Preparations RequiredNo specific preparation is required.
  • Report Time7 days

Why is the FISH for Synovial Sarcoma test important?

FISH for Synovial Sarcoma is crucial for the accurate diagnosis of this rare cancer. By identifying the characteristic chromosomal translocation, physicians can differentiate synovial sarcoma from other soft tissue tumors, leading to appropriate treatment planning.

Is fasting necessary for this test?

No, fasting is not required for this test as it is performed on tissue samples, typically obtained through a biopsy.

Home Sample Collection Process
1
Book your convenient slot
Book your convenient slot
2
Sample Collection by Phlebotomist
Sample Collection by Phlebotomist
3
Reporting of the sample at lab
Reporting of the sample at lab
4
Download Reports
Download Reports
Frequently Asked Questions

This test detects the specific chromosomal translocation involving the SYT and SSX genes, which is highly characteristic of synovial sarcoma. Identification of this translocation helps in confirming the diagnosis.

Your doctor might recommend this test if you have a mass or tumor near joints or other areas, and there is suspicion or need to rule out synovial sarcoma based on clinical or histological assessments.

Normal cells without the translocation will not show the fusion signal under the microscope. In synovial sarcoma, a fusion signal or abnormally close proximity of the SYT and SSX gene signals would be observed.

The risks associated with this test are mainly related to the biopsy procedure, which may include infection, bleeding, or pain at the site of the biopsy.

If the test indicates the presence of the chromosomal translocation characteristic of synovial sarcoma, you should consult an oncologist specializing in sarcomas for further management and treatment options.

Treatment for synovial sarcoma typically involves a combination of surgery to remove the tumor, chemotherapy to kill cancer cells, and radiation therapy to eliminate any remaining cancer cells in the tumor area.

FISH for Synovial Sarcoma is primarily a diagnostic tool. Other methods such as imaging and monitoring of tumor markers are more commonly used to monitor the progress of the disease.

Technical errors, poor sample quality, or the presence of interfering substances can affect the test results. It is important that the test is performed in a specialized laboratory by experienced personnel.

The presence of the SYT-SSX translocation confirms the diagnosis of synovial sarcoma, but it does not provide information on the aggressiveness or prognosis of the disease.

Yes, besides FISH, other molecular techniques such as RT-PCR or next-generation sequencing can also detect the characteristic translocations in synovial sarcoma.

Most cases of synovial sarcoma are sporadic and not inherited. However, genetic factors may play a role in a small proportion of cases.

Potential complications include local recurrence of the tumor, metastasis to other organs such as the lungs, and side effects from treatments like chemotherapy and radiation.

The prognosis of synovial sarcoma varies based on factors such as tumor size, location, extent of spread, and response to treatment. Early detection and treatment can improve the prognosis.

FISH for Synovial Sarcoma is a vital diagnostic tool that helps in the accurate identification of this rare type of cancer. By detecting the specific chromosomal translocation characteristic of synovial sarcoma, it plays a crucial role in ensuring that an accurate diagnosis is made and the most appropriate treatment is provided. If you or a loved one is suspected to have synovial sarcoma, or if you have been diagnosed and want more information, it is essential to talk to a doctor who can guide you through the diagnostic process and discuss the best treatment options based on your specific case.

FISH for Synovial Sarcoma
₹ 8900
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