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Lab Test

FISH for SRY Deletion

FISH, or Fluorescence In Situ Hybridization, for SRY deletion is a diagnostic test that targets the SRY gene, which is pivotal in the development of male sexual characteristics. The SRY gene, located on the Y chromosome, initiates the process that leads to the development of testes in males. A deletion of the SRY gene can cause disorders of sex development (DSD), where an individual’s sexual characteristics may not align with their chromosomal sex. Recognizing an SRY deletion is fundamental in understanding and managing DSD.


  • Profile Name: FISH for SRY Deletion
  • Sample Type: Blood
  • Preparations Required: No specific preparation is needed.
  • Report Time: 7 Days

FISH for SRY deletion uses fluorescent probes that bind to the SRY gene on the Y chromosome. When viewed under a fluorescence microscope, the absence of fluorescence signals in a male sample can indicate the deletion of the SRY gene.

Home Sample Collection Process
1
Book your convenient slot
Book your convenient slot
2
Sample Collection by Phlebotomist
Sample Collection by Phlebotomist
3
Reporting of the sample at lab
Reporting of the sample at lab
4
Download Reports
Download Reports
Frequently Asked Questions

The FISH for SRY deletion test is crucial for diagnosing disorders of sex development (DSD). When the SRY gene is deleted, individuals with a Y chromosome may not develop typical male sexual characteristics. This test helps in the early detection and management of DSD, which can be vital for the affected individual’s physical and psychological health.

No, fasting is not required for this test as it is performed on blood or tissue samples.

The FISH for SRY deletion test provides information about the presence or absence of the SRY gene on the Y chromosome. The absence of the SRY gene in individuals with a Y chromosome is indicative of a disorder of sex development.

This test is usually recommended in cases where an individual exhibits ambiguous sexual characteristics or when there is a suspicion of a disorder of sex development based on clinical findings.

This test is generally performed once for diagnostic purposes.

In typical males, the SRY gene should be present on the Y chromosome. In females, the SRY gene is normally absent. The absence of the SRY gene in a male karyotype indicates SRY deletion.

There are minimal risks associated with this test. It may involve drawing blood, which carries very slight risks such as infection or bruising at the puncture site.

If the test indicates an SRY deletion, consultation with a geneticist or an endocrinologist specializing in disorders of sex development is recommended.

Yes, this test can be performed on amniotic fluid or chorionic villus samples during pregnancy if there is suspicion of a disorder of sex development in the fetus.

Management for individuals with an SRY deletion and DSD is tailored to each individual's needs. It may involve hormone therapy, surgery, psychological counseling, and ongoing medical management.

Technical errors in sample processing or analysis can affect the results. Genetic variations other than SRY deletion may also influence sexual development.

As with any diagnostic test, there is always a possibility of false positives or false negatives. If the results are inconclusive or inconsistent with clinical findings, the test may be repeated or supplemented with other diagnostic tests.

SRY deletion is a genetic issue and is not affected by modifiable factors. It is present from birth.

An individual with an SRY deletion and associated DSD may face psychological challenges. Counseling and support, especially during childhood, are important components of management.

The prognosis for individuals with an SRY deletion varies and depends on the severity of the DSD and the treatment provided. With appropriate medical management and psychological support, many individuals lead healthy, fulfilling lives.

FISH for SRY deletion is an important diagnostic tool in the evaluation of disorders of sex development. This test detects the presence or absence of the SRY gene, which is critical in the development of male sexual characteristics. Understanding whether the SRY gene is deleted is essential in diagnosing and managing DSD. Early diagnosis and a personalized approach to treatment and support are crucial for individuals affected by SRY deletion.

FISH for SRY Deletion
₹ 4500
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