FISH for MLL - Price, Normal Range | Sprint Diagnostics Hyderabad

Patient Preparing : No special preparation is required for this test.

₹ 4300


Fluorescence In Situ Hybridization (FISH) for MLL (Mixed Lineage Leukemia) gene rearrangements is a critical diagnostic test utilized in the diagnosis and monitoring of various hematological malignancies, such as acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). The MLL gene, located on chromosome 11q23, plays a vital role in the regulation of gene expression, particularly during embryonic development. Abnormalities in the MLL gene, including rearrangements and translocations, are associated with the development of leukemia.

The FISH technique utilizes fluorescent probes that bind to the DNA sequences of interest – in this case, the MLL gene. If the gene is rearranged or translocated, the fluorescent pattern observed under the microscope will be altered. Detecting these abnormalities helps to confirm the diagnosis, guide treatment options, and monitor the disease progression or response to therapy.

Test Name FISH for MLL
Sample Type Blood or Bone Marrow
Preparations Required No special preparation is required for this test.
Report Time 5 days
Price in Hyderabad ₹ 4300

What is the MLL gene and why is it important?

The MLL gene is essential in regulating the expression of various genes, especially during the development of the fetus. Abnormalities in the MLL gene, such as rearrangements or translocations, can lead to uncontrolled cell growth and are associated with various types of leukemia.

What is the purpose of the FISH for MLL test?

FISH for MLL is used to detect rearrangements of the MLL gene. These rearrangements are often associated with the development of leukemia. The test is used for diagnosis, risk stratification, and monitoring of the disease.

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What is the MLL gene and why is it important?

The MLL gene is essential in regulating the expression of various genes, especially during the development of the fetus. Abnormalities in the MLL gene, such as rearrangements or translocations, can lead to uncontrolled cell growth and are associated with various types of leukemia.

What is the purpose of the FISH for MLL test?

FISH for MLL is used to detect rearrangements of the MLL gene. These rearrangements are often associated with the development of leukemia. The test is used for diagnosis, risk stratification, and monitoring of the disease.

Who should get the FISH for MLL test?

This test is recommended for individuals who have been diagnosed with or are suspected of having acute leukemia, especially if they have features suggestive of MLL gene involvement. It is also used for monitoring patients with known MLL gene rearrangements.

How is the FISH for MLL test performed?

A sample of blood or bone marrow is taken from the patient. The sample is then processed in the laboratory, where fluorescent probes specific to the MLL gene are applied. The sample is examined under a fluorescence microscope to detect any abnormalities in the MLL gene.

What does a positive result indicate?

A positive result indicates that there is a rearrangement of the MLL gene. This rearrangement is associated with an increased risk of leukemia and may have implications for the prognosis and treatment of the disease.

How does the FISH for MLL test affect treatment decisions?

The presence of MLL gene rearrangements can affect the prognosis and dictate the aggressiveness of therapy. Knowledge of MLL gene status helps doctors to tailor treatment plans accordingly.

Is there any preparation required for the test?

No special preparation is required for the FISH for MLL test.

Can the FISH for MLL test be used to monitor the response to treatment?

Yes, FISH for MLL can be used to monitor the disease during and after treatment. Changes in the MLL gene status may reflect the response to therapy.

What are the implications of having an MLL gene rearrangement?

Having an MLL gene rearrangement is associated with an increased risk of developing leukemia. In patients already diagnosed with leukemia, MLL gene rearrangements may be associated with a more aggressive disease course.

What should I do if my test comes back positive for MLL gene rearrangement?

If your test comes back positive for MLL gene rearrangement, it is important to discuss the results with your doctor. Your doctor will explain what these findings mean for your specific condition and will help you understand the next steps in terms of treatment and management.

Are there any risks associated with the FISH for MLL test?

The risks associated with the FISH for MLL test are minimal and are similar to those associated with a standard blood draw. These include pain or discomfort at the needle site, bruising, infection, or excessive bleeding.

Can the FISH for MLL test be done on children?

Yes, the test can be performed on patients of all ages, including children.

Are there any factors that can affect the test results?

Certain medications and underlying health conditions may affect the results of the test. It's important to discuss your medical history and any medications you are taking with your doctor.

How reliable is the FISH for MLL test?

The FISH for MLL test is highly reliable and is considered a gold standard for the detection of MLL gene rearrangements. However, no test is perfect, and there are instances where false-positive or false-negative results can occur.

Are there other tests that should be done in conjunction with the FISH for MLL test?

The FISH for MLL test is often done as part of a comprehensive evaluation that may include other genetic tests, blood tests, and bone marrow examinations.

The FISH for MLL test is an essential tool in the diagnosis and management of leukemias associated with MLL gene rearrangements. Understanding your test results can be complex, so it is important to communicate with your doctor about what they mean and how they will impact your treatment and management plan.

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