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FISH for IgH-MAF Fusion / t(14;16)

Fluorescence In Situ Hybridization, commonly known as FISH, for IgH-MAF fusion/t(14;16) is a diagnostic test that is used in the evaluation and management of multiple myeloma. Multiple myeloma is a type of cancer that affects plasma cells, which are a type of white blood cell responsible for producing antibodies. In multiple myeloma, abnormal plasma cells multiply uncontrollably and produce abnormal antibodies. The t(14;16) translocation is a specific chromosomal abnormality in which there is an exchange of genetic material between chromosomes 14 and 16. This leads to the fusion of the Immunoglobulin Heavy Chain (IgH) gene on chromosome 14 with the MAF (c-MAF) gene on chromosome 16.


  • Profile Name: FISH for IgH-MAF Fusion / t(14;16)
  • Sample Type: Bone marrow or blood sample
  • Preparations Required: No special preparation is needed for this test.
  • Report Time: 5 days

The FISH test uses fluorescent probes that bind to specific areas on chromosomes, and in this case, the areas of interest are the IgH and MAF genes. Under a fluorescence microscope, it is possible to see if the IgH-MAF fusion is present.

Home Sample Collection Process
1
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Book your convenient slot
2
Sample Collection by Phlebotomist
Sample Collection by Phlebotomist
3
Reporting of the sample at lab
Reporting of the sample at lab
4
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Download Reports
Frequently Asked Questions

The t(14;16) translocation is a chromosomal abnormality in which parts of chromosomes 14 and 16 are exchanged. This results in the fusion of the IgH gene with the MAF gene and is associated with multiple myeloma.

Identifying the presence of the IgH-MAF fusion is crucial as it can provide information about the genetic basis of a patient's multiple myeloma. It has been associated with a more aggressive disease course, and knowing whether it is present can help guide treatment decisions.

A blood or bone marrow sample is taken from the patient. The sample is then stained with fluorescent probes that bind to the IgH and MAF genes. The chromosomes can then be visualized under a fluorescence microscope, allowing for the detection of the IgH-MAF fusion.

Individuals who have been diagnosed with multiple myeloma, or those who are suspected of having the disease based on clinical symptoms and other lab tests, might be recommended to undergo this test.

A positive result for the IgH-MAF fusion indicates the presence of the t(14;16) translocation and suggests that the patient’s multiple myeloma might be more aggressive. This information is important for treatment planning.

Yes, FISH is just one of several tests that can be done to diagnose and monitor multiple myeloma. Others might include blood tests, bone marrow biopsy, imaging studies, and additional genetic tests.

There is no special preparation needed for the FISH test. However, it is always good to follow any instructions provided by your healthcare professional.

Yes, patients with the IgH-MAF fusion might require more aggressive treatment due to the nature of their disease. This can include different combinations of chemotherapy, targeted therapy, or stem cell transplantation.

The risks associated with the FISH test for IgH-MAF fusion are mainly related to the blood or bone marrow draw, which might include bleeding, infection, or bruising at the site of the draw.

Coverage for this test may vary depending on your health insurance. It's best to check with your insurance company to find out if the test is covered under your plan.

A negative result means that the IgH-MAF fusion is not present in the analyzed cells. However, multiple myeloma can be caused by various genetic abnormalities, so your doctor might recommend additional testing.

This test is typically performed at the time of diagnosis to help classify the type of multiple myeloma. However, it may also be repeated if there is a change in the course of the disease.

Although the t(14;16) translocation is usually a stable feature, the disease itself can evolve over time. Monitoring for other genetic changes or clinical changes may be necessary.

If the test results are abnormal, it is important to consult with a hematologist or oncologist who specializes in the treatment of multiple myeloma.

No, this test is just one component of diagnosing multiple myeloma. A diagnosis is usually based on a combination of clinical symptoms, lab tests, and imaging studies.

The FISH for IgH-MAF Fusion/t(14;16) is an essential component in the diagnosis and management of multiple myeloma. It provides critical information on the genetic abnormalities that may be driving the disease, which can help in risk stratification and guiding treatment decisions. If you or a loved one are facing a diagnosis of multiple myeloma, it's important to discuss with your doctor the significance of this test and how it can be used in conjunction with other information to optimize the treatment strategy

FISH for IgH-MAF fusion / t(14:16)
₹ 4300
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