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FISH for IgH Gene Rearrangement

FISH for IgH Gene Rearrangement

The FISH (Fluorescence In Situ Hybridization) test for IgH gene rearrangement is a crucial diagnostic tool used in the assessment of certain types of blood cancers, including non-Hodgkin lymphoma and multiple myeloma. The IgH gene is responsible for encoding the immunoglobulin heavy chain, which is a component of antibodies. When the IgH gene is abnormally rearranged, it can lead to the overproduction of certain proteins, contributing to the development and progression of cancer.

In the FISH test, fluorescent probes attach specifically to the IgH gene in the DNA. This enables the visualization of the gene's structure and arrangement under a microscope, which helps determine whether there is a rearrangement of the IgH gene.


  • Test NameFISH for IgH Gene Rearrangement
  • Sample TypeBone marrow or blood sample
  • Preparations RequiredNo specific preparation is needed for this test.
  • Report Time5 days

What is the IgH gene and why is its arrangement important?

The IgH gene encodes for the heavy chain of antibodies. When this gene undergoes rearrangement, it can cause the overproduction of specific proteins. In some cases, this leads to the development of cancers like non-Hodgkin lymphoma and multiple myeloma.

What does it mean if there is a rearrangement in the IgH gene?

A rearrangement in the IgH gene means that there is an abnormal configuration of the gene. This can lead to the uncontrolled production of proteins, and possibly the development of blood cancers.

Home Sample Collection Process
1
Book your convenient slot
Book your convenient slot
2
Sample Collection by Phlebotomist
Sample Collection by Phlebotomist
3
Reporting of the sample at lab
Reporting of the sample at lab
4
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Download Reports
Frequently Asked Questions

The FISH test for IgH gene rearrangement uses fluorescent probes to bind to the IgH gene. Under a microscope, the arrangement of the gene can be visualized, helping to detect any abnormalities in the gene’s structure.

This test is important because it helps diagnose specific types of blood cancers, such as non-Hodgkin lymphoma and multiple myeloma. Additionally, it can help doctors make decisions regarding the most appropriate treatment options and predict how the disease may progress.

Individuals who have been diagnosed with, or are suspected to have, non-Hodgkin lymphoma or multiple myeloma, might be recommended by their doctor to undergo this test.

The test is performed on a sample of bone marrow or blood. The DNA from the cells in the sample is stained with fluorescent probes that attach to the IgH gene. The sample is then analyzed under a microscope.

A positive result for IgH gene rearrangement indicates that there is an abnormality in the gene, which might be associated with certain types of blood cancers. A negative result suggests a normal arrangement of the IgH gene.

The test itself doesn’t have side effects, but obtaining a bone marrow sample can be uncomfortable and carry risks such as infection and bleeding.

Yes, the test can be performed on peripheral blood in some cases, but bone marrow is often preferred as it is usually more informative.

FISH focuses on detecting specific genetic changes, such as rearrangements, whereas other genetic tests may sequence genes or assess the expression levels of certain genes.

No specific preparation is needed for this test, but it is advisable to follow any instructions given by your doctor.

Yes, based on the results, your doctor will be able to tailor the treatment plan to your specific condition.

As with any test, there is a small chance of false positives or negatives, but the FISH test is generally considered to be highly reliable.

If the test comes back positive, the next steps involve consultation with your doctor to discuss appropriate treatment options and management strategies for the condition.

Coverage for the FISH test for IgH gene rearrangement depends on your insurance plan. It's recommended to check with your insurance provider to determine if the test is covered.

FISH testing for IgH gene rearrangement plays an invaluable role in the diagnosis and management of certain blood cancers. Understanding the results, implications, and options for treatment is vital for patients and their families. Always remember to have open communication with your doctor regarding the results and their implications to ensure the best possible outcome and management of your health.

FISH for IgH gene rearrangement
₹ 4300
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