FISH for HER2/neu - Paraffin Block- Price, Normal Range | Sprint Diagnostics Hyderabad

Patient Preparing : No specific preparation is needed for this test.

₹ 9900


The FISH (Fluorescence In Situ Hybridization) test for HER2/neu is a vital tool used in the diagnosis and management of breast cancer. HER2/neu, also known as ERBB2, is a gene that codes for a protein receptor on the surface of cells. This receptor is part of a family of proteins that are important in cell growth and division. When there is an overexpression of HER2/neu, it can result in uncontrolled cell growth, which may contribute to the development and progression of breast cancer.

In this particular test, tissue samples that are embedded in paraffin blocks are analyzed. The tissue is treated with fluorescent probes that bind specifically to the HER2/neu gene. The fluorescence signals are then examined under a microscope to determine if there is an amplification or overexpression of the HER2/neu gene.

Test Name FISH for HER2/neu - Paraffin Block
Sample Type Paraffin-embedded tissue
Preparations Required No specific preparation is needed for this test.
Report Time 7 days
Price in Hyderabad ₹ 9900

What is HER2/neu and why is it important in breast cancer?

HER2/neu is a gene that codes for a protein receptor involved in cell growth and division. In some breast cancers, this gene is amplified or overexpressed, leading to aggressive tumor growth. Knowing the HER2/neu status is essential for determining the appropriate treatment plan.

What does it mean if there is amplification or overexpression of the HER2/neu gene?

Amplification or overexpression of the HER2/neu gene means that there are too many copies of the gene or an overproduction of the HER2 protein. This is often associated with more aggressive forms of breast cancer and can affect treatment choices.

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What is the FISH test for HER2/neu?

The FISH test for HER2/neu is a diagnostic test that uses fluorescent probes to visualize and analyze the HER2/neu gene in tissue samples. This test is used to determine if there is an amplification or overexpression of the HER2/neu gene.

Why is the FISH test for HER2/neu important?

Knowing the HER2/neu status of a breast tumor is critical for treatment planning. Certain drugs specifically target HER2-positive tumors and can be very effective in treating these cancers. The test can also provide prognostic information.

Who should undergo the FISH test for HER2/neu?

Anyone diagnosed with breast cancer should undergo testing for HER2/neu status as part of the standard diagnostic workup. This information is essential for making informed treatment decisions.

How is the test performed?

The test is performed on tissue samples that are usually obtained through a biopsy. The tissue is embedded in paraffin blocks, sectioned, and then treated with fluorescent probes that bind specifically to the HER2/neu gene. The tissue is then examined under a microscope.

What do the results of the FISH test for HER2/neu indicate?

A positive result indicates that there is amplification or overexpression of the HER2/neu gene. A negative result indicates that the HER2/neu gene is not amplified. This information will help guide treatment decisions.

What are the treatment options for HER2-positive breast cancer?

HER2-positive breast cancers can be treated with drugs that specifically target the HER2 protein, such as trastuzumab (Herceptin) and lapatinib (Tykerb). These may be used in combination with chemotherapy or other treatments.

Are there any risks or side effects associated with the FISH test for HER2/neu?

The FISH test itself does not have side effects, but the biopsy procedure to obtain tissue samples can have risks such as infection, bleeding, or discomfort.

Can the FISH test for HER2/neu be done on any type of sample?

The FISH test for HER2/neu is typically performed on paraffin-embedded tissue samples, which are prepared from biopsy or surgery specimens.

Can the FISH test for HER2/neu predict how aggressive the cancer is?

Yes, HER2/neu amplification is often associated with more aggressive forms of breast cancer, so knowing the HER2/neu status can provide prognostic information.

Is HER2/neu amplification only associated with breast cancer?

While HER2/neu amplification is most commonly associated with breast cancer, it can also occur in other types of cancer, such as stomach cancer.

How reliable is the FISH test for HER2/neu?

The FISH test is considered very reliable for determining HER2/neu status and is often used when other tests, such as IHC, are inconclusive.

What is the next step if the test comes back positive for HER2/neu amplification?

If the test is positive, your doctor will discuss treatment options with you, which may include drugs that target HER2.

Can HER2 status change over time?

It’s possible for HER2 status to change, particularly after treatment. Sometimes, tumors that were initially HER2-negative become HER2-positive, and vice versa.

The FISH test for HER2/neu is a crucial diagnostic tool in the management of breast cancer. This test assists in determining the HER2/neu status of the tumor, which has significant implications for treatment planning and prognosis. It is essential to work closely with your doctor to understand the results of this test and to make informed decisions about your care.

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