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FISH for FGFR1 Gene Rearrangement

FISH for FGFR1 Gene Rearrangement

The FISH (Fluorescence In Situ Hybridization) test for FGFR1 gene rearrangement is an essential diagnostic tool used in the field of oncology. The FGFR1 gene encodes for Fibroblast Growth Factor Receptor 1, which is a protein involved in various cellular processes including cell growth and division. When there is a rearrangement in the FGFR1 gene, it can lead to the production of an altered protein, which may contribute to the development and progression of cancer, particularly certain hematological malignancies and solid tumors.

The FISH test for FGFR1 gene rearrangement employs fluorescent probes to visualize and analyze the FGFR1 gene in tissue samples, identifying any structural changes. This information is critical for accurate diagnosis, guiding treatment decisions, and monitoring the effectiveness of therapy.


  • Test NameFISH for FGFR1 Gene Rearrangement
  • Sample TypeTissue
  • Preparations RequiredNo specific preparation is needed for this test.
  • Report Time7 days

What is the FGFR1 gene and why is it important?

The FGFR1 gene encodes a protein called Fibroblast Growth Factor Receptor 1, which is part of a family of receptors involved in cell growth, division, and repair. Abnormalities in this gene can contribute to the development of cancer.

What does it mean if there is a rearrangement in the FGFR1 gene?

A rearrangement in the FGFR1 gene means that there is a change in the structure of the gene. This can lead to the production of altered proteins, which may contribute to the development and progression of cancer.

Home Sample Collection Process

1
Book your convenient slot
Book your convenient slot
2
Sample Collection by Phlebotomist
Sample Collection by Phlebotomist
3
Reporting of the sample at lab
Reporting of the sample at lab
4
Download Reports
Download Reports
Frequently Asked Questions

The FISH test for FGFR1 gene rearrangement is a diagnostic test that uses fluorescent probes to visualize and analyze the FGFR1 gene in tissue samples, detecting any structural changes.

This test is essential for the accurate diagnosis of cancers associated with FGFR1 gene rearrangements. It also helps in guiding treatment decisions and monitoring the efficacy of therapies.

Individuals suspected of having a cancer associated with FGFR1 gene rearrangements, or those who have been diagnosed with such a cancer and are being monitored during treatment, should undergo this test.

The test is performed on a tissue sample, usually obtained through a biopsy. The sample is treated with fluorescent probes that bind specifically to the FGFR1 gene, and is then analyzed under a microscope.

If the test shows a rearrangement in the FGFR1 gene, it may indicate the presence of a cancer associated with this genetic change. This information can guide doctors in selecting the most effective treatment options.

Treatment options may include surgery, chemotherapy, radiation therapy, and targeted therapies that specifically target the altered FGFR1 protein.

There are minimal risks associated with the FISH test itself. However, obtaining a tissue sample through a biopsy procedure may have risks such as infection, bleeding, or pain at the biopsy site.

Most FGFR1 gene rearrangements are not inherited but are acquired during a person’s lifetime. These changes occur in the DNA of individual cells and are referred to as somatic mutations.

There is no clear evidence that lifestyle changes can impact the risk of FGFR1 gene rearrangements. However, maintaining a healthy lifestyle may reduce the risk of cancer in general.

The prognosis and curability of cancers associated with FGFR1 gene rearrangement vary depending on various factors, such as the type and stage of cancer.

There are targeted therapies available that specifically inhibit the FGFR1 protein, which may be effective in treating certain cancers associated with FGFR1 gene rearrangement.

The availability of the FISH test for FGFR1 gene rearrangement may vary by location. Consult your local healthcare services or a doctor for information on testing availability in your area.

If the test results indicate an FGFR1 gene rearrangement, it is important to consult an oncologist for further evaluation and management.

The role of the FGFR1 gene in cancer and the importance of the FISH test for FGFR1 gene rearrangement is vital for patients and their families. This knowledge can help in making informed decisions about treatment and managing expectations. It is crucial to have a comprehensive and multidisciplinary approach to the management of cancers associated with FGFR1 gene rearrangements, and to communicate openly with healthcare professionals to optimize outcomes.

FISH for FGFR1 gene rearrangement
₹ 4900
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Locations Near You in Hyderabad
  • 4KM from Madhapur
  • 3KM from Banjara Hills
  • 1.9KM from Yusufguda
  • 3KM from Madhura Nagar
  • 5KM from Shaikpet