FISH for Ewing's Sarcoma (EWSR1 gene) - Price, Normal Range | Sprint Diagnostics Hyderabad

Patient Preparing : No special preparation is needed for this test. It is a standard tissue biopsy procedure.

₹ 8000


Ewing’s Sarcoma is a rare type of cancer that primarily affects the bone or soft tissue. It’s most common in teenagers and young adults but can occur at any age. Ewing’s Sarcoma is characterized by the presence of specific genetic changes, particularly in the EWSR1 gene. The FISH (Fluorescence In Situ Hybridization) test for Ewing's Sarcoma is a diagnostic test that helps in detecting the rearrangements in the EWSR1 gene. This is particularly important in diagnosing, prognostication, and management of Ewing's Sarcoma.

The EWSR1 gene is involved in encoding a protein that is believed to play a role in various cellular processes. The rearrangements of this gene are common in Ewing’s Sarcoma and related tumors, leading to the formation of abnormal proteins that contribute to cancer development. The FISH test uses fluorescent probes to visualize and analyze the EWSR1 gene rearrangements in tissue samples.

Test Name FISH for Ewing's Sarcoma (EWSR1 gene)
Sample Type Paraffin embedded tissue blocks
Preparations Required No special preparation is needed for this test. It is a standard tissue biopsy procedure.
Report Time 10 days
Price in Hyderabad â‚ą 8000

What is Ewing's Sarcoma?

Ewing's Sarcoma is a rare type of cancer that primarily affects bones or the soft tissue around bones. It is more common in teenagers and young adults but can occur at any age.

What is the role of the EWSR1 gene in Ewing's Sarcoma?

The EWSR1 gene is involved in encoding a protein that plays a role in various cellular processes. In Ewing's Sarcoma, this gene undergoes rearrangement, which leads to the formation of abnormal proteins that contribute to the development of cancer.

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What is FISH for Ewing's Sarcoma?

FISH for Ewing's Sarcoma is a diagnostic test that uses fluorescent probes to detect and analyze the rearrangements in the EWSR1 gene. This test is critical in confirming the diagnosis of Ewing's Sarcoma.

How is FISH for Ewing's Sarcoma performed?

The test is performed on a tissue sample, usually obtained through a biopsy. The tissue is treated with fluorescent probes that bind specifically to the EWSR1 gene, and the sample is then analyzed under a microscope.

Why is the FISH test important for patients with Ewing's Sarcoma?

The FISH test is vital for confirming the diagnosis of Ewing's Sarcoma, as the presence of EWSR1 gene rearrangements is a characteristic feature of this cancer. Additionally, this information can help in guiding treatment decisions and prognostication.

What does a positive EWSR1 rearrangement result indicate?

A positive EWSR1 rearrangement result indicates the presence of Ewing's Sarcoma or a related tumor. It is critical for a patient to consult an oncologist for further evaluation and management.

How does the result of the FISH test affect treatment options?

The result of the FISH test can help in selecting specific therapies that target the genetic abnormalities in Ewing's Sarcoma. It is essential in personalized cancer treatment planning.

Are there risks associated with the FISH test for Ewing's Sarcoma?

There are minimal risks associated with the FISH test itself. However, obtaining a tissue sample through a biopsy procedure may have risks, including infection, bleeding, or pain at the biopsy site.

Can EWSR1 gene rearrangement occur in other types of cancer?

Yes, EWSR1 gene rearrangements can occur in other tumors as well. However, it is most characteristically associated with Ewing’s Sarcoma and related tumors.

What are the treatment options for Ewing's Sarcoma?

Treatment options for Ewing's Sarcoma include surgery, chemotherapy, radiation therapy, and targeted therapies that specifically address the genetic abnormalities in the cancer cells.

Is Ewing's Sarcoma curable?

The prognosis for Ewing's Sarcoma varies depending on various factors, including the stage of the disease, the age of the patient, and the location of the tumor. Early detection and aggressive treatment can lead to better outcomes.

How often should a person be tested for Ewing's Sarcoma if they have a family history of the disease?

There is no established screening protocol for Ewing's Sarcoma. Individuals with a family history should consult a doctor for personalized advice on monitoring and risk reduction.

Can lifestyle or environmental factors cause EWSR1 gene rearrangement?

There is no clear evidence that lifestyle or environmental factors cause EWSR1 gene rearrangements. These rearrangements are thought to be random events.

Can the FISH test for Ewing's Sarcoma be done on blood samples?

The FISH test for Ewing's Sarcoma is typically done on tissue samples. It is not usually performed on blood samples.

What kind of doctor should be consulted in case of abnormal EWSR1 rearrangement results?

In case of abnormal EWSR1 rearrangement results, it is essential to consult an oncologist specializing in bone and soft tissue tumors for further evaluation and treatment.

The importance of the EWSR1 gene in the diagnosis and management of Ewing's Sarcoma, patients and their families can be better equipped to understand and navigate the challenges of this disease. The FISH test is a crucial tool in this process, aiding in the confirmation of diagnosis and informing treatment decisions. If you or someone you know is facing a diagnosis of Ewing's Sarcoma, it is imperative to work closely with an oncologist for the best possible care and outcomes.

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