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FISH for E2A Rearrangement

FISH for E2A Rearrangement

E2A is a gene that plays a crucial role in the development of cells in the immune system. Abnormalities in the E2A gene can lead to the development of leukemia and lymphomas, which are cancers of the blood and lymphatic systems. The FISH (Fluorescence In Situ Hybridization) test for E2A rearrangement is a diagnostic test that helps detect abnormalities in the E2A gene by using fluorescent probes to visualize the genetic material within cells. This test is particularly important for the diagnosis and management of blood cancers where the E2A gene is involved.

E2A rearrangement can result in the production of an abnormal protein that drives the uncontrolled growth of white blood cells, which is a hallmark of leukemia. By detecting these rearrangements, doctors can make a more accurate diagnosis and develop a targeted treatment plan for patients.


  • Test NameFISH for E2A Rearrangement
  • Sample TypeBone Marrow or Peripheral Blood
  • Preparations RequiredNo special preparation is needed for this test. It is a standard bone marrow aspiration or blood draw.
  • Report Time5 days

What is E2A gene and what is its role in the body?

E2A is a gene that encodes proteins essential for the development of immune cells. It is involved in the regulation of gene expression during the differentiation of B and T cells, which are components of the immune system.

What is E2A rearrangement and why is it significant?

E2A rearrangement refers to a genetic abnormality where the E2A gene is abnormally reorganized. This rearrangement can cause the gene to function improperly, potentially leading to the development of blood cancers such as leukemia and lymphomas.

Home Sample Collection Process

1
Book your convenient slot
Book your convenient slot
2
Sample Collection by Phlebotomist
Sample Collection by Phlebotomist
3
Reporting of the sample at lab
Reporting of the sample at lab
4
Download Reports
Download Reports
Frequently Asked Questions

FISH, or Fluorescence In Situ Hybridization, is a test that uses fluorescent probes to bind to specific DNA sequences, in this case, the E2A gene. It allows for the visualization of the genetic material under a microscope and can detect if there is an abnormal rearrangement in the E2A gene.

The test is performed using a sample of the patient’s bone marrow or peripheral blood. The sample is then treated with fluorescent probes that bind to the E2A gene, and the chromosomes are visualized under a special microscope.

This test is typically recommended for patients who are suspected of having leukemia or lymphomas, especially if there are clinical signs that suggest abnormalities in the immune system.

The test provides information about the presence or absence of an E2A rearrangement. If present, it can help in diagnosing specific types of leukemia or lymphomas and can provide guidance for treatment options.

A positive result indicates that there is an abnormal rearrangement in the E2A gene. This is associated with certain types of blood cancers, and further evaluation by a doctor specializing in hematology or oncology is needed.

Treatment varies depending on the specific type of blood cancer associated with E2A rearrangement. Options may include chemotherapy, targeted therapy, and stem cell transplantation.

There are minimal risks associated with this test. For blood samples, risks are similar to those of a regular blood draw. Bone marrow aspiration carries some risks, including infection and bleeding at the aspiration site.

There is no clear evidence that lifestyle or environmental factors cause E2A rearrangements. It is likely a result of random genetic mutations.

Most E2A rearrangements are not inherited but occur randomly. However, a family history of blood cancers may increase the risk of developing these conditions.

The presence of E2A rearrangements can be associated with a more aggressive course of disease in certain types of leukemia and lymphoma, which may affect the patient's prognosis.

There is no known way to prevent E2A rearrangements as they are generally caused by random genetic mutations.

Additional tests such as complete blood counts, immunophenotyping, and genetic testing for other mutations may also be necessary to make a complete diagnosis.

If an abnormal E2A rearrangement is detected, it is important to consult a hematologist or an oncologist for specialized care and management.

In E2A rearrangements, it is clear that they play a critical role in the development of certain blood cancers. The FISH test for E2A rearrangement is a vital diagnostic tool that helps in the early detection and effective management of these diseases. If you or someone you know is suspected of having blood cancer or has been diagnosed with E2A rearrangement, it is important to seek the expertise of a hematologist or oncologist. While blood cancers can be life-changing, advancements in targeted therapies have improved the outcomes and quality of life for many patients.

FISH for E2A rearrangement
₹ 3900
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Locations Near You in Hyderabad
  • 4KM from Madhapur
  • 3KM from Banjara Hills
  • 1.9KM from Yusufguda
  • 3KM from Madhura Nagar
  • 5KM from Shaikpet