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FISH for del(13q)

FISH for del(13q)

Fluorescence In Situ Hybridization, commonly known as FISH, for del(13q) is a diagnostic test that is used to detect the deletion of a part of chromosome 13, specifically the long arm labeled as q. This deletion is significant as it is associated with various medical conditions, including chronic lymphocytic leukemia (CLL), multiple myeloma, and other hematological malignancies. Identifying the presence of this deletion can help doctors make a diagnosis, determine a prognosis, and develop a treatment plan.

Chromosome 13q deletion is one of the common chromosomal abnormalities found in CLL and is generally associated with a more favorable prognosis compared to other chromosomal aberrations. However, the prognosis can vary depending on other factors and the extent of the deletion.

FISH utilizes fluorescent probes that bind to specific DNA sequences on chromosomes. By analyzing the chromosomes under a fluorescence microscope, technicians can detect if there is a deletion in the long arm of chromosome 13.

  • Test NameFISH for del(13q)
  • Sample TypeBlood or Bone Marrow
  • Preparations RequiredNo special preparation is needed for this test. However, it's important to follow any specific instructions provided by your doctor.
  • Report Time5 days

What does the FISH for del(13q) test detect?

This test detects the deletion of a portion of the long arm of chromosome 13, which is known as 13q deletion. This deletion can be associated with chronic lymphocytic leukemia, multiple myeloma, and other hematologic disorders.

How is the sample for this test collected?

The sample is usually collected through a blood draw or a bone marrow biopsy, depending on the condition being tested for and the doctor's recommendation.

Home Sample Collection Process

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Book your convenient slot
Sample Collection by Phlebotomist
Sample Collection by Phlebotomist
Reporting of the sample at lab
Reporting of the sample at lab
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Download Reports
Frequently Asked Questions

A 13q deletion in chronic lymphocytic leukemia is generally associated with a more favorable prognosis compared to other chromosomal abnormalities. However, the prognosis can vary depending on the size of the deletion and the presence of additional chromosomal abnormalities.

The presence or absence of a 13q deletion can help to classify CLL into different risk groups. This information can be used to guide treatment decisions, as those with a 13q deletion may respond differently to treatment compared to those without the deletion.

No special preparation is necessary. However, it is always good to follow the instructions provided by your doctor.

This test is primarily recommended for patients who have been diagnosed with or are suspected of having chronic lymphocytic leukemia, multiple myeloma, or other hematological disorders where a 13q deletion may be relevant.

This particular FISH test is designed to detect the deletion in chromosome 13. However, other FISH tests can be ordered to detect different chromosomal abnormalities.

If a 13q deletion is detected, it is advisable to consult a hematologist or oncologist who specializes in blood disorders and cancer.

This test can be repeated if needed, especially if monitoring the progression of a disease or the response to treatment.

A blood draw is minimally invasive and may involve slight pain. A bone marrow biopsy can cause discomfort and is generally performed with local anesthesia to minimize pain.

The presence of a 13q deletion, especially as an isolated finding, in CLL is often associated with a slower disease progression. The test results can help doctors determine how aggressively the disease might progress.

Yes, it can be used to monitor the response to treatment, especially if the 13q deletion is present initially.

Coverage for this test may vary depending on your insurance plan. It is advisable to consult with your insurance company before undergoing the test.

Most cases of 13q deletions associated with hematological malignancies are acquired and not inherited. However, there are some rare genetic disorders associated with 13q deletion that are inherited.

Yes, there are other genetic tests that can also detect chromosomal abnormalities, such as karyotyping and chromosomal microarray analysis. However, FISH is often preferred for its accuracy and specificity in detecting specific abnormalities.

In conclusion, FISH for del(13q) is a highly important and specialized test used to detect 13q deletions in the context of various hematological disorders. It plays a significant role in the diagnosis, prognosis, and treatment decision-making process. If you or a loved one is diagnosed with a condition that warrants this test, it is essential to communicate with your doctor to understand the implications and the course of action best tailored to the patient’s health.

FISH for del(13q)
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