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FISH for CRLF2 Gene Rearrangement

FISH for CRLF2 Gene Rearrangement

Fluorescence In Situ Hybridization (FISH) for CRLF2 Gene Rearrangement is a specialized laboratory test used to detect abnormalities in the CRLF2 (Cytokine Receptor Like Factor 2) gene. The CRLF2 gene plays a crucial role in the immune system's function, particularly in the development of B cells, which are a type of white blood cell. When the CRLF2 gene undergoes rearrangement, it can contribute to the development of certain types of leukemia, including B-cell acute lymphoblastic leukemia (B-ALL) and other hematologic malignancies.

The FISH technique uses fluorescent probes that bind to specific DNA sequences on chromosomes. By examining the pattern of fluorescence, it’s possible to identify the presence or absence of specific genetic abnormalities, such as the rearrangement of the CRLF2 gene.

The FISH for CRLF2 Gene Rearrangement test is of particular importance in the context of hematologic malignancies. By understanding the genetic makeup of the disease, clinicians can make more informed decisions regarding prognosis and treatment.

  • Test NameFISH for CRLF2 Gene Rearrangement
  • Sample TypeBlood or Bone Marrow
  • Preparations RequiredThere are no specific preparations required for this test. However, it's important to follow any instructions given by your doctor.
  • Report Time5 days
Why is the FISH for CRLF2 Gene Rearrangement test performed?

This test is performed to detect the presence of rearrangements in the CRLF2 gene, which are associated with certain types of leukemia. It helps in diagnosis, prognosis, and deciding treatment strategies for hematologic malignancies.

How is the sample collected for this test?

The sample for this test is usually collected through a blood draw or a bone marrow biopsy.

Home Sample Collection Process

1
Book your convenient slot
Book your convenient slot
2
Sample Collection by Phlebotomist
Sample Collection by Phlebotomist
3
Reporting of the sample at lab
Reporting of the sample at lab
4
Download Reports
Download Reports
Frequently Asked Questions

If CRLF2 gene rearrangement is detected, it means that there may be an increased risk or presence of certain types of leukemia, especially B-cell acute lymphoblastic leukemia.

No, fasting is not required for this test.

There is no special preparation needed for this test. However, it’s important to follow any specific instructions given by your doctor.

No, this test requires specialized equipment and should be performed in a laboratory setting.

A blood draw is minimally painful. However, if a bone marrow sample is needed, you may experience some discomfort or pain.

Abnormal results may indicate an underlying hematologic malignancy. The doctor may recommend further testing and evaluation to confirm the diagnosis and determine the most appropriate treatment plan.

FISH for CRLF2 specifically looks for rearrangements in the CRLF2 gene, whereas other genetic tests may look for different mutations or abnormalities associated with leukemia.

Yes, the results of this test can play a crucial role in treatment decisions, as specific gene rearrangements may be targeted by particular therapies.

While it is primarily used in the context of leukemia, it may also be used in research or other clinical settings to study the role of the CRLF2 gene in other conditions.

If your test results are abnormal, it is important to consult your doctor to understand what the results mean and what steps should be taken next.

The risks are minimal and are similar to those of a regular blood draw. In cases where a bone marrow sample is taken, there may be some discomfort or pain, as well as a slight risk of infection.

The FISH technique is considered highly reliable, but the interpretation of results should always be done in the context of the patient’s clinical presentation and history.

This test may be performed alongside other genetic tests and laboratory evaluations, as part of a comprehensive assessment of hematologic malignancies.

By providing valuable information about the genetic characteristics of leukemia, the FISH for CRLF2 Gene Rearrangement test is an important tool in modern medicine. It helps doctors to establish more accurate diagnoses and to create more effective, personalized treatment plans. If you have undergone this test or have been recommended to do so, it is important to maintain open communication with your doctor to understand the implications and make informed decisions regarding your health.

FISH for CRLF2 gene rearrangement
₹ 4900
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