FISH for CRLF2 Gene Rearrangement- Price, Normal Range | Sprint Diagnostics Hyderabad

Patient Preparing : There are no specific preparations required for this test. However, it's important to follow any instructions given by your doctor.

₹ 4900


Fluorescence In Situ Hybridization (FISH) for CRLF2 Gene Rearrangement is a specialized laboratory test used to detect abnormalities in the CRLF2 (Cytokine Receptor Like Factor 2) gene. The CRLF2 gene plays a crucial role in the immune system's function, particularly in the development of B cells, which are a type of white blood cell. When the CRLF2 gene undergoes rearrangement, it can contribute to the development of certain types of leukemia, including B-cell acute lymphoblastic leukemia (B-ALL) and other hematologic malignancies.

The FISH technique uses fluorescent probes that bind to specific DNA sequences on chromosomes. By examining the pattern of fluorescence, it’s possible to identify the presence or absence of specific genetic abnormalities, such as the rearrangement of the CRLF2 gene.

The FISH for CRLF2 Gene Rearrangement test is of particular importance in the context of hematologic malignancies. By understanding the genetic makeup of the disease, clinicians can make more informed decisions regarding prognosis and treatment.

Test Name FISH for CRLF2 Gene Rearrangement
Sample Type Blood or Bone Marrow
Preparations Required There are no specific preparations required for this test. However, it's important to follow any instructions given by your doctor.
Report Time 5days
Price in Hyderabad ₹ 4900

Why is the FISH for CRLF2 Gene Rearrangement test performed?

This test is performed to detect the presence of rearrangements in the CRLF2 gene, which are associated with certain types of leukemia. It helps in diagnosis, prognosis, and deciding treatment strategies for hematologic malignancies.

How is the sample collected for this test?

The sample for this test is usually collected through a blood draw or a bone marrow biopsy.

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What does it mean if CRLF2 gene rearrangement is detected?

If CRLF2 gene rearrangement is detected, it means that there may be an increased risk or presence of certain types of leukemia, especially B-cell acute lymphoblastic leukemia.

Is fasting required for this test?

No, fasting is not required for this test.

How should I prepare for this test?

There is no special preparation needed for this test. However, it’s important to follow any specific instructions given by your doctor.

Can this test be done at home?

No, this test requires specialized equipment and should be performed in a laboratory setting.

Is this test painful?

A blood draw is minimally painful. However, if a bone marrow sample is needed, you may experience some discomfort or pain.

What are the implications of abnormal results?

Abnormal results may indicate an underlying hematologic malignancy. The doctor may recommend further testing and evaluation to confirm the diagnosis and determine the most appropriate treatment plan.

How is this test different from other genetic tests for leukemia?

FISH for CRLF2 specifically looks for rearrangements in the CRLF2 gene, whereas other genetic tests may look for different mutations or abnormalities associated with leukemia.

Can the results of this test affect treatment decisions?

Yes, the results of this test can play a crucial role in treatment decisions, as specific gene rearrangements may be targeted by particular therapies.

Is this test only used for leukemia?

While it is primarily used in the context of leukemia, it may also be used in research or other clinical settings to study the role of the CRLF2 gene in other conditions.

What should I do if my test results are abnormal?

If your test results are abnormal, it is important to consult your doctor to understand what the results mean and what steps should be taken next.

Are there any risks associated with this test?

The risks are minimal and are similar to those of a regular blood draw. In cases where a bone marrow sample is taken, there may be some discomfort or pain, as well as a slight risk of infection.

How reliable are the results of the FISH for CRLF2 Gene Rearrangement test?

The FISH technique is considered highly reliable, but the interpretation of results should always be done in the context of the patient’s clinical presentation and history.

Are there other tests that should be done along with this one?

This test may be performed alongside other genetic tests and laboratory evaluations, as part of a comprehensive assessment of hematologic malignancies.

By providing valuable information about the genetic characteristics of leukemia, the FISH for CRLF2 Gene Rearrangement test is an important tool in modern medicine. It helps doctors to establish more accurate diagnoses and to create more effective, personalized treatment plans. If you have undergone this test or have been recommended to do so, it is important to maintain open communication with your doctor to understand the implications and make informed decisions regarding your health.

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