FISH for Aneuploidy - 6 Markers 13/16/18/21/X/Y (Prenatal)
Fluorescence In Situ Hybridization, commonly known as FISH, is a molecular cytogenetic technique that is used to detect and visualize specific DNA sequences on chromosomes. The FISH for Aneuploidy test utilizing 6 markers - 13, 16, 18, 21, X, and Y - is a prenatal diagnostic test that assesses the presence of an abnormal number of these specific chromosomes in a fetus. This test is paramount in prenatal diagnostics as it provides insight into potential chromosomal disorders which may affect the fetus.
The FISH technique employs fluorescent probes which attach to the chromosomes in a sample, allowing them to be observed and enumerated under a microscope. It particularly evaluates chromosomes 13, 16, 18, 21, X, and Y. Abnormalities in chromosome 13 are associated with Patau syndrome, chromosome 18 with Edwards syndrome, and chromosome 21 with Down syndrome. Chromosome 16 abnormalities may also be related to developmental issues. The X and Y chromosomes are important in determining the sex of the baby and any irregularities in these chromosomes can lead to sex-linked disorders such as Turner syndrome and Klinefelter syndrome.
Test NameFISH for Aneuploidy - 6 Markers 13/16/18/21/X/Y (Prenatal)
Sample TypeAmniotic fluid or chorionic villus sample (CVS)
Preparations RequiredThere are no specific preparations needed for the test, but it’s important to follow the doctor’s instructions regarding the collection procedures through amniocentesis or CVS.
Report Time5 days
What is the significance of the FISH for Aneuploidy test with 6 markers?
This test is vital for detecting chromosomal abnormalities in the fetus, particularly for chromosomes 13, 16, 18, 21, X, and Y. Early diagnosis can provide crucial information regarding conditions like Down syndrome, Patau syndrome, Edwards syndrome, and sex-linked disorders.
How is this test conducted?
This test requires a sample of amniotic fluid or chorionic villus, which is obtained through amniocentesis or CVS. Fluorescent probes are used in the lab to bind to specific chromosomes in the sample, which can then be visualized under a microscope.
Home Sample Collection Process
1
Book your convenient slot
2
Sample Collection by Phlebotomist
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Reporting of the sample at lab
4
Download Reports
Frequently Asked Questions
This test is usually performed during the second trimester of pregnancy, but it can also be done earlier through chorionic villus sampling (CVS).
Abnormal results might indicate an irregular number of chromosomes, which could be associated with chromosomal disorders such as Down syndrome, Patau syndrome, Edwards syndrome, or sex-linked disorders.
The test itself does not pose any risks, but the procedures for obtaining the sample, such as amniocentesis or CVS, carry a slight risk of infection or miscarriage.
Consult your doctor to thoroughly understand the results. It is important to discuss the available options and steps for managing the pregnancy and preparing for any required care.
While FISH is highly accurate, it is often used in conjunction with other genetictests for a comprehensive assessment.
No, lifestyle or medication does not affect the number of chromosomes in fetal cells.
Yes, genetic counseling is highly recommended to comprehend the implications of abnormal results and to make well-informed decisions.
Yes, by analyzing the X and Y chromosomes, the test can determine the sex of the baby.
No, this test is generally recommended for high-risk pregnancies where there is a higher chance of chromosomal abnormalities.
FISH is a diagnostic test, meaning it can provide definite information about the number of chromosomes, unlike screening tests which only indicate the likelihood of a chromosomal abnormality.
No, this test specifically targets chromosomes 13, 16, 18, 21, X, and Y. It does not provide information on structural abnormalities or other chromosomes.
Yes, alternatives include karyotyping, microarray analysis, and non-invasive prenatal testing (NIPT).
FISH can only analyze specific chromosomes and does not detect other genetic disorders or structural abnormalities. Additionally, it requires invasive procedures for sample collection.
The FISH for Aneuploidy with 6 markers - 13, 16, 18, 21, X, and Y - is a powerful tool for early detection of chromosomal abnormalities in the fetus. This information is critical in helping expecting parents and their medical team make informed decisions about the pregnancy and the care that may be needed. It is essential to discuss prenatal testing options with your doctor to ensure the best possible care for both the mother and the baby. Through proper guidance, testing, and support, expecting parents can be better prepared to welcome a new life into their family.
FISH for Aneuploidy - 6 markers 13/16/18/21/X/Y (Prenatal)
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