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FISH for AML/ETO - t(8;21)

FISH for AML/ETO - t(8;21)

FISH, or Fluorescence In Situ Hybridization, for AML/ETO - t(8;21) is a specialized diagnostic test that aims to detect a specific chromosomal translocation associated with acute myeloid leukemia (AML). AML is a form of cancer that affects the bone marrow, where blood cells are produced. The t(8;21) translocation involves the exchange of genetic material between chromosomes 8 and 21. This translocation results in the formation of the AML/ETO fusion gene, which is associated with a subtype of AML. The detection of this fusion gene is critical for confirming the diagnosis of AML, guiding treatment, and monitoring response to therapy.


  • Test NameFISH for AML/ETO - t(8;21)
  • Sample TypeBlood or Bone Marrow
  • Preparations RequiredNo specific preparations are required for this test. However, it is advisable to follow any instructions provided by your doctor or the laboratory.
  • Report Time5 days

What is the FISH for AML/ETO - t(8;21) test?

FISH for AML/ETO - t(8;21) is a diagnostic test that utilizes fluorescent probes to identify the chromosomal translocation between chromosomes 8 and 21, leading to the formation of the AML/ETO fusion gene. This fusion gene is often associated with a subtype of acute myeloid leukemia (AML).

Why is the FISH for AML/ETO - t(8;21) test important?

The test is vital in diagnosing a specific subtype of AML, associated with the t(8;21) translocation. It helps to provide information regarding the prognosis and is necessary for guiding treatment decisions.

Home Sample Collection Process

1
Book your convenient slot
Book your convenient slot
2
Sample Collection by Phlebotomist
Sample Collection by Phlebotomist
3
Reporting of the sample at lab
Reporting of the sample at lab
4
Download Reports
Download Reports
Frequently Asked Questions

The test is performed on a sample of blood or bone marrow. Fluorescent probes specific to the regions of interest on chromosomes 8 and 21 are used. These probes bind to the chromosomes, and under a fluorescence microscope, the lab technician can observe whether or not the AML/ETO fusion gene is present.

If the test detects the AML/ETO fusion gene, it suggests the presence of the t(8;21) translocation and confirms the diagnosis of a specific subtype of AML. If not detected, the patient likely does not have this subtype of AML.

Knowing the presence of the AML/ETO fusion gene helps doctors determine the appropriate treatment protocol for the patient. Patients with this fusion gene might require a different treatment approach compared to those without it.

The test is generally recommended for individuals suspected to have AML, particularly if they exhibit specific symptoms or have abnormal results from other blood tests.

The risks are primarily associated with the collection of blood or bone marrow samples, including pain, infection, or bruising at the puncture site.

Technical issues or the quality of the sample might affect the test results. It is essential that the test be conducted by an accredited laboratory to minimize any errors.

The AML/ETO fusion gene is believed to play a role in blocking the normal differentiation of blood cells, leading to an accumulation of immature blood cells, which is characteristic of AML.

Yes, the FISH for AML/ETO - t(8;21) test can be used to monitor minimal residual disease and to evaluate the effectiveness of treatment.

Yes, patients with the AML/ETO fusion gene often have a more favorable prognosis compared to other subtypes of AML. However, the overall outcome also depends on various other factors including patient's age, general health, and response to treatment.

As with any diagnostic test, there is a possibility of false-positive or false-negative results. This is why it's important that the test be interpreted in conjunction with other diagnostic information.

This test is not used for screening family members as AML with the t(8;21) translocation is not inherited.

If the test results are positive, it is crucial to consult with your doctor to understand the results and discuss the next steps in managing your condition.

Yes, alternative tests include reverse transcription-polymerase chain reaction (RT-PCR) and conventional cytogenetics. Your doctor can advise on which test is most suitable for your condition.

The FISH for AML/ETO - t(8;21) is a vital diagnostic tool that can provide essential information for diagnosing, managing, and monitoring a specific subtype of acute myeloid leukemia. The test's results can help in making important treatment decisions. If you have been diagnosed with AML or are experiencing symptoms consistent with leukemia, consult your doctor to discuss if the FISH for AML/ETO - t(8;21) test is appropriate for you.

FISH for AML/ETO - t(8;21)
₹ 4100
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Locations Near You in Hyderabad
  • 4KM from Madhapur
  • 3KM from Banjara Hills
  • 1.9KM from Yusufguda
  • 3KM from Madhura Nagar
  • 5KM from Shaikpet