FISH for AML/ETO - t(8;21)- Price, Normal Range | Sprint Diagnostics Hyderabad

Patient Preparing : No specific preparations are required for this test. However, it is advisable to follow any instructions provided by your doctor or the laboratory.

₹ 4100


FISH, or Fluorescence In Situ Hybridization, for AML/ETO - t(8;21) is a specialized diagnostic test that aims to detect a specific chromosomal translocation associated with acute myeloid leukemia (AML). AML is a form of cancer that affects the bone marrow, where blood cells are produced. The t(8;21) translocation involves the exchange of genetic material between chromosomes 8 and 21. This translocation results in the formation of the AML/ETO fusion gene, which is associated with a subtype of AML. The detection of this fusion gene is critical for confirming the diagnosis of AML, guiding treatment, and monitoring response to therapy.

Test Name FISH for AML/ETO - t(8;21)
Sample Type Blood or Bone Marrow
Preparations Required No specific preparations are required for this test. However, it is advisable to follow any instructions provided by your doctor or the laboratory.
Report Time 5 days
Price in Hyderabad ₹ 4100

What is the FISH for AML/ETO - t(8;21) test?

FISH for AML/ETO - t(8;21) is a diagnostic test that utilizes fluorescent probes to identify the chromosomal translocation between chromosomes 8 and 21, leading to the formation of the AML/ETO fusion gene. This fusion gene is often associated with a subtype of acute myeloid leukemia (AML).

Why is the FISH for AML/ETO - t(8;21) test important?

The test is vital in diagnosing a specific subtype of AML, associated with the t(8;21) translocation. It helps to provide information regarding the prognosis and is necessary for guiding treatment decisions.

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How is the FISH for AML/ETO - t(8;21) test performed?

The test is performed on a sample of blood or bone marrow. Fluorescent probes specific to the regions of interest on chromosomes 8 and 21 are used. These probes bind to the chromosomes, and under a fluorescence microscope, the lab technician can observe whether or not the AML/ETO fusion gene is present.

What do the test results mean?

If the test detects the AML/ETO fusion gene, it suggests the presence of the t(8;21) translocation and confirms the diagnosis of a specific subtype of AML. If not detected, the patient likely does not have this subtype of AML.

How is this test used in the treatment of AML?

Knowing the presence of the AML/ETO fusion gene helps doctors determine the appropriate treatment protocol for the patient. Patients with this fusion gene might require a different treatment approach compared to those without it.

Who should get the FISH for AML/ETO - t(8;21) test?

The test is generally recommended for individuals suspected to have AML, particularly if they exhibit specific symptoms or have abnormal results from other blood tests.

Are there any risks associated with this test?

The risks are primarily associated with the collection of blood or bone marrow samples, including pain, infection, or bruising at the puncture site.

What factors can affect the test results?

Technical issues or the quality of the sample might affect the test results. It is essential that the test be conducted by an accredited laboratory to minimize any errors.

What is the role of the AML/ETO fusion gene in leukemia?

The AML/ETO fusion gene is believed to play a role in blocking the normal differentiation of blood cells, leading to an accumulation of immature blood cells, which is characteristic of AML.

Can the test be used to monitor the effectiveness of treatment?

Yes, the FISH for AML/ETO - t(8;21) test can be used to monitor minimal residual disease and to evaluate the effectiveness of treatment.

Does the presence of the AML/ETO fusion gene impact prognosis?

Yes, patients with the AML/ETO fusion gene often have a more favorable prognosis compared to other subtypes of AML. However, the overall outcome also depends on various other factors including patient's age, general health, and response to treatment.

Is there a possibility of a false positive or false negative result?

As with any diagnostic test, there is a possibility of false-positive or false-negative results. This is why it's important that the test be interpreted in conjunction with other diagnostic information.

Can this test be used for family members of AML patients?

This test is not used for screening family members as AML with the t(8;21) translocation is not inherited.

What should I do if my test results are positive?

If the test results are positive, it is crucial to consult with your doctor to understand the results and discuss the next steps in managing your condition.

Are there any alternatives to the FISH test for detecting AML/ETO - t(8;21)?

Yes, alternative tests include reverse transcription-polymerase chain reaction (RT-PCR) and conventional cytogenetics. Your doctor can advise on which test is most suitable for your condition.

The FISH for AML/ETO - t(8;21) is a vital diagnostic tool that can provide essential information for diagnosing, managing, and monitoring a specific subtype of acute myeloid leukemia. The test's results can help in making important treatment decisions. If you have been diagnosed with AML or are experiencing symptoms consistent with leukemia, consult your doctor to discuss if the FISH for AML/ETO - t(8;21) test is appropriate for you.

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