FISH for ABL2 Gene Rearrangement- Price, Normal Range | Sprint Diagnostics Hyderabad

Patient Preparing : There are no special preparations needed for this test. It is recommended to follow any instructions given by your doctor or the laboratory.

₹ 4900


The FISH for ABL2 gene rearrangement is a sophisticated diagnostic test that specifically targets the ABL2 gene to detect rearrangements. The ABL2 gene is known to play an essential role in the development and maintenance of the cellular cytoskeleton and is found on chromosome 1. Abnormalities or rearrangements in this gene are associated with certain forms of leukemia. The FISH (Fluorescence in situ Hybridization) technique uses fluorescent probes to attach to the ABL2 gene, allowing visualization of any rearrangements under a microscope. This is particularly useful for the diagnosis, prognosis, and monitoring of hematological malignancies such as leukemia.

Test Name FISH for ABL2 Gene Rearrangement
Sample Type Blood or Bone Marrow
Preparations Required There are no special preparations needed for this test. It is recommended to follow any instructions given by your doctor or the laboratory.
Report Time 5 days
Price in Hyderabad ₹ 4900

What is the FISH for ABL2 Gene Rearrangement?

FISH for ABL2 Gene Rearrangement is a diagnostic test that uses fluorescent probes to detect and visualize rearrangements in the ABL2 gene, which is associated with certain types of leukemia.

Why is the FISH for ABL2 Gene Rearrangement important?

This test is essential for the accurate diagnosis of specific forms of leukemia that are associated with rearrangements in the ABL2 gene. It also assists in determining the prognosis and formulating the treatment plan for patients with these malignancies.

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How is this test performed?

A blood or bone marrow sample is collected from the patient. The sample is then treated with fluorescent probes that bind to the ABL2 gene. Using a special microscope, the laboratory technicians can then observe any rearrangements in the gene.

What do the results mean?

If the test detects a rearrangement in the ABL2 gene, it may indicate the presence of a specific type of leukemia. The absence of a rearrangement generally means that the ABL2 gene is normal. However, the results should always be interpreted by a doctor familiar with the patient's medical history and other test results.

Who should get this test?

Individuals who have been diagnosed with leukemia, or have symptoms suggestive of leukemia, and need further genetic testing to confirm the diagnosis or determine the specific subtype of leukemia, may be recommended this test.

How will the results affect the treatment?

The presence of ABL2 gene rearrangement may necessitate targeted therapy or specialized treatment plans. Your doctor will use the information from this test, along with other diagnostics, to create the most effective treatment plan for your condition.

Are there any risks associated with this test?

The risks associated with this test are mainly due to the blood or bone marrow sample collection, which can cause slight pain, bruising, or infection at the site of the needle insertion.

Can this test be used for conditions other than leukemia?

Primarily, the test is used for the diagnosis of specific leukemias. However, it may be used in research settings to study the ABL2 gene in other conditions.

What factors can affect the test results?

Technical issues, sample quality, and variations in laboratory procedures can affect the test results. It is important to ensure that the test is conducted by a reputable laboratory.

Is the test conclusive for a diagnosis?

No, the test is generally a part of a series of diagnostic tests used to confirm a diagnosis of leukemia. Your doctor will take into consideration the results from various tests before making a final diagnosis.

What are the alternatives to the FISH test for ABL2 gene rearrangement?

Alternative tests for detecting gene rearrangements include conventional karyotyping and next- generation sequencing (NGS).

What does it mean if the rearrangement is not detected?

If the rearrangement is not detected, it could mean that the ABL2 gene is normal, or that the rearrangement is present at levels below the detection limits of the test.

Can this test be done during treatment?

Yes, this test can be used during treatment to monitor the effectiveness of therapy and to check for the presence of minimal residual disease.

What should I do if the test results are abnormal?

If the test results show an ABL2 gene rearrangement, it is important to consult your doctor for an interpretation of the results and to discuss the appropriate next steps for treatment.

Is the test covered by insurance?

The coverage for the FISH for ABL2 Gene Rearrangement test can vary depending on your insurance plan. It is recommended to contact your insurance provider to determine if the test is covered and to inquire about any out-of-pocket costs.

The FISH for ABL2 Gene Rearrangement is a powerful diagnostic tool in the arsenal of tests used to diagnose, manage, and monitor certain types of leukemia. It is highly specific and can provide valuable information to your doctor in tailoring your treatment plan. If you or a loved one are facing a diagnosis of leukemia, or if you are already undergoing treatment, this test may be an important part of your care. Speak to your doctor about the FISH for ABL2 Gene Rearrangement and how it can be used in your specific case.

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