FISH for ABL1 Gene Rearrangement- Price, Normal Range | Sprint Diagnostics Hyderabad

Patient Preparing : No specific preparation is required for this test. However, it is always wise to follow any instructions given by your doctor regarding the sample collection procedure.

₹ 4900

Fluorescence in situ hybridization (FISH) for ABL1 gene rearrangement is an innovative diagnostic test that examines the ABL1 gene for alterations. The ABL1 gene is located on chromosome 9 and encodes a protein that is involved in various cellular processes. This test is primarily used in diagnosing chronic myeloid leukemia (CML) and sometimes acute lymphoblastic leukemia (ALL), as these diseases are often associated with the rearrangement of the ABL1 gene. FISH uses fluorescent probes to visualize and map the genetic material in an individual's cells. This allows for the detection of genetic abnormalities linked to various diseases, especially cancer.

Test Name FISH for ABL1 Gene Rearrangement
Sample Type Blood or Bone Marrow
Preparations Required No specific preparation is required for this test. However, it is always wise to follow any instructions given by your doctor regarding the sample collection procedure.
Report Time 5 days
Price in Hyderabad ₹ 4900

What is FISH for ABL1 Gene Rearrangement?

FISH for ABL1 gene rearrangement is a diagnostic test that uses fluorescent probes to detect rearrangements in the ABL1 gene, commonly associated with chronic myeloid leukemia and sometimes acute lymphoblastic leukemia.

Why is this test important?

This test is crucial for the diagnosis of chronic myeloid leukemia and can also be used in monitoring the progression of the disease and the effectiveness of treatment. It helps in determining the Philadelphia chromosome, which results from a translocation between chromosomes 9 and 22.

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How is the test performed?

A blood or bone marrow sample is collected from the patient. The sample is then exposed to fluorescent probes that attach to the ABL1 gene. Under a fluorescent microscope, any rearrangements in the gene can be visually detected.

What do the results mean? A positive result indicates the presence of a rearrangement in the ABL1

gene, which is commonly associated with chronic myeloid leukemia. A negative result means that no rearrangement was detected. However, interpretation of the results should be done by a doctor familiar with your medical history.

Who should get this test?

Individuals suspected of having chronic myeloid leukemia, based on symptoms or other blood tests, should undergo this test. It can also be used for monitoring the progression and treatment of the disease.

How will the results affect my treatment?

If the test results are positive, it generally indicates a diagnosis of chronic myeloid leukemia. The results will guide your doctor in determining the appropriate course of treatment, which usually includes targeted therapies that inhibit the activity of the BCR-ABL protein.

How long does it take to receive the results?

The turnaround time for this test is typically 7-14 days, though it may vary based on the laboratory conducting the test.

Are there any risks or side effects associated with this test?

The risks associated with the FISH for ABL1 gene rearrangement test are primarily related to the collection of a blood or bone marrow sample, which may include discomfort, bruising, or infection at the puncture site.

What factors may affect the results?

Technical issues, sample quality, and laboratory variations may affect the results. It's important to have the test done at a reputable laboratory.

Can this test detect other types of cancer?

While the test is primarily used to detect chronic myeloid leukemia, it can sometimes be used in the diagnosis of other cancers, like acute lymphoblastic leukemia, if they have a similar genetic abnormality.

What is the Philadelphia chromosome?

The Philadelphia chromosome is a small, abnormal chromosome formed by the translocation of parts of chromosomes 9 and 22. It produces a hybrid BCR-ABL gene, which can lead to chronic myeloid leukemia.

Can this test be used to monitor my response to therapy?

Yes, this test is often used to monitor the response to therapy in patients with chronic myeloid leukemia. It helps in assessing the effectiveness of treatment in reducing the number of cells with the BCR-ABL gene.

Is this test covered by insurance?

Coverage for this test depends on your insurance policy. It is best to contact your insurance provider for details regarding coverage and possible out-of-pocket costs.

What should I do if my test results are abnormal?

If your test results are abnormal, it is important to consult your doctor for a thorough evaluation and to discuss the next steps for diagnosis and treatment.

Are there any alternative tests?

Yes, alternative tests include conventional cytogenetics, polymerase chain reaction (PCR) for BCR-ABL1 transcripts, and next-generation sequencing panels for leukemia.

FISH for ABL1 Gene Rearrangement is a vital diagnostic tool for the detection and management of chronic myeloid leukemia. It is essential for those who are suspected of having CML or are already diagnosed and need monitoring. The test has revolutionized the way CML is diagnosed and has paved the way for targeted therapy. If you have any further questions or concerns regarding this test, it is important to discuss them with your doctor.

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