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Fluorescence In Situ Hybridization (FISH) for 3 Markers

Fluorescence In Situ Hybridization (FISH) for 3 Markers

Fluorescence In Situ Hybridization, commonly known as FISH, is an advanced molecular diagnostic technique that is used to detect and visualize specific DNA sequences within cells by using fluorescent probes. In FISH for 3 markers, three different fluorescent probes are employed, each designed to bind to a specific DNA sequence. This technique is highly valuable in various areas of medicine, especially in genetics and oncology, and is essential for diagnosing and monitoring several genetic disorders and cancers.

FISH is an essential tool for analyzing chromosomal abnormalities at the molecular level. This technique uses fluorescent probes that bind to complementary DNA sequences on chromosomes. These probes fluoresce under specific wavelengths of light, and this fluorescence can be observed under a microscope.

FISH for 3 markers involves the use of three distinct fluorescent probes to target three different DNA sequences or regions. This is particularly beneficial when analyzing complex genetic diseases where multiple chromosomal aberrations may be involved. Additionally, this multiplex approach is crucial for simultaneously observing the interactions between different chromosomal features.


  • Test NameFluorescence In Situ Hybridization (FISH) for 3 Markers
  • Sample TypeBlood, Bone Marrow
  • Preparations RequiredNo specific preparation is required prior to the test.
  • Report Time5 days

What is FISH for 3 markers?

FISH for 3 markers is a specialized variant of the FISH technique that uses three different fluorescent probes to simultaneously detect and visualize three specific DNA sequences or chromosomal regions in a sample.

Why is FISH for 3 markers important?

FISH for 3 markers is important because it allows for the simultaneous analysis of multiple genetic regions, which is essential in diagnosing complex genetic disorders and certain types of cancer that may involve multiple genetic alterations.

Home Sample Collection Process
1
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Book your convenient slot
2
Sample Collection by Phlebotomist
Sample Collection by Phlebotomist
3
Reporting of the sample at lab
Reporting of the sample at lab
4
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Frequently Asked Questions

A sample of blood, bone marrow, or tissue is fixed onto a glass slide. Three fluorescent probes are applied to the sample. Once they bind to their target DNA sequences, they are visualized under a fluorescence microscope.

This test can detect a variety of genetic abnormalities, such as gene deletions, duplications, translocations, and inversions, and can also be used to determine the number of specific chromosomes present in a cell.

Individuals who are suspected of having a genetic disorder or cancer involving multiple chromosomal abnormalities, or those who require monitoring of a known genetic condition, should consider having this test done.

There is no specific preparation required for the FISH test. However, it’s important to inform your doctor of any medications or supplements you are taking.

No, fasting is not required for the FISH test.

The results of the FISH test should be interpreted by a specialist, as they can be complex. The presence or absence of fluorescence signals indicates the presence or absence of the target DNA sequences.

Yes, FISH can be performed on samples obtained through amniocentesis or chorionic villus sampling for prenatal diagnosis.

Although highly accurate, FISH for 3 markers can only detect known genetic sequences for which the probes are designed. It cannot detect unexpected mutations or genetic changes.

By using three probes, FISH for 3 markers allows for the simultaneous analysis of three genetic regions, making it more efficient and comprehensive compared to conventional FISH that uses a single probe.

Technical issues, such as poor probe binding or sample degradation, can affect the results.

The results can have implications for diagnosis, prognosis, and treatment decisions. This information is essential for personalized treatment planning.

You should consult a geneticist or oncologist if your test results are abnormal, as they are specialists in interpreting these results and planning further management.

Yes, some medications and factors such as recent chemotherapy can affect the test results. Inform your doctor about your medical history and any medications you are taking.

FISH for 3 markers is a powerful diagnostic tool that provides crucial insights into the genetic makeup of cells. This information is invaluable in the diagnosis and management of a range of genetic disorders and cancers. Always discuss the results and subsequent steps with a specialist who is experienced in genetic diagnostics and personalized treatment planning.

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