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FISH for 1p/19q Co-deletion

1p/19q Co-Deletion by FISH

1p/19q Co-Deletion by FISH (Fluorescence In Situ Hybridization) is a specialized laboratory technique that is used to detect the simultaneous loss of chromosomal arms 1p and 19q. This co-deletion is particularly significant in the context of brain tumors, primarily oligodendrogliomas, as it has implications on diagnosis, prognosis, and treatment.

Oligodendrogliomas are a type of brain tumor that arises from oligodendrocytes, the cells responsible for producing the myelin sheath around nerve fibers. The presence of a 1p/19q co-deletion is characteristic of oligodendrogliomas and is associated with a better response to chemotherapy and a more favorable prognosis compared to tumors without this co-deletion.

  • Test Name1p/19q Co-Deletion by FISH
  • Sample TypeTissue
  • Preparations RequiredNo specific preparations are required for the patient, but it is important to follow the doctor's instructions regarding the biopsy procedure.
  • Report Time7 days

What is 1p/19q Co-Deletion by FISH?

FISH for 1p/19q co-deletion is a test that uses fluorescent probes to detect the simultaneous loss of genetic material on the short arm of chromosome 1 (1p) and the long arm of chromosome 19 (19q). This co-deletion is often found in oligodendrogliomas.

Why is FISH for 1p/19q co-deletion performed?

This test is performed to help diagnose oligodendrogliomas, to determine prognosis, and to guide treatment decisions. The presence of the 1p/19q co-deletion is associated with a better response to treatment and a more favorable outcome.

Home Sample Collection Process

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Book your convenient slot
Sample Collection by Phlebotomist
Sample Collection by Phlebotomist
Reporting of the sample at lab
Reporting of the sample at lab
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Download Reports
Frequently Asked Questions

The test is performed on tissue samples, usually obtained through a biopsy of the brain tumor. Fluorescent probes are used to bind to specific areas on chromosomes 1 and 19. Under a fluorescence microscope, the absence of fluorescence in the regions of interest indicates a deletion.

If the 1p/19q co-deletion is present, it typically indicates that the tumor is an oligodendroglioma. This co-deletion is associated with increased sensitivity to chemotherapy and a generally better prognosis compared to tumors without this genetic feature.

There is no specific preparation required for the patient. However, as the test is performed on tissue samples, it is important to follow the doctor's instructions regarding the biopsy procedure.

The risks associated with FISH for 1p/19q are mainly related to the biopsy procedure, which may include infection, bleeding, and reactions to anesthesia.

The results help in the diagnosis of oligodendrogliomas and play a vital role in planning treatment. A positive result for 1p/19q co-deletion can indicate a potential better response to chemotherapy.

Treatment options for tumors with 1p/19q co-deletion may include surgery, radiation therapy, and chemotherapy. The specific treatment plan will be based on the stage and characteristics of the tumor.

Lifestyle changes don't affect the results of the test, but a healthy lifestyle can generally improve overall health and well-being during cancer treatment.

If the test results are abnormal, consultation with a neuro-oncologist or a doctor specialized in brain tumors is recommended.

This test is typically performed once to assist in the diagnosis and management of a brain tumor. Your doctor will guide you if further testing is required.

No, this test requires a tissue sample from the tumor, which must be obtained in a clinical setting by a medical professional.

Medications do not typically affect the genetic features of the tumor and thus are not likely to affect the results of this test.

The costs for the FISH test, biopsy, and subsequent treatments can vary. It's important to check with your health insurance and hospital regarding the expenses.

Yes, the test is available in many countries around the world. However, it's advisable to check with local healthcare providers regarding the availability.

Understanding the genetic characteristics of brain tumors is essential for providing effective treatment. The FISH for 1p/19q co-deletion test offers valuable information for patients with oligodendrogliomas and can influence the approach to therapy. It is important for patients to discuss the results with their doctor to fully understand the implications and next steps in the management of their condition.

FISH for 1p/19q co deletion
₹ 9000
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Locations Near You in Hyderabad
  • 4KM from Madhapur
  • 3KM from Banjara Hills
  • 1.9KM from Yusufguda
  • 3KM from Madhura Nagar
  • 5KM from Shaikpet