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Factor XII (Hageman) Activity

Factor XII (Hageman) Activity

Factor XII, also known as Hageman factor, is a protein that is a part of the blood clotting process. The Factor XII Activity test measures the activity level of Factor XII in your blood and is important for evaluating the intrinsic pathway of the clotting cascade. Factor XII deficiency is a rare genetic disorder that can result in increased bleeding, or in some cases, increased clotting.

The Factor XII Activity test is essential in diagnosing Factor XII deficiency, which is a rare blood disorder. Unlike other clotting factor deficiencies, Factor XII deficiency doesn't always lead to severe bleeding problems but is associated with a prolonged clotting time in laboratory tests. Additionally, Factor XII is involved in inflammatory processes, and its deficiency might have implications beyond clotting.


  • Test NameFactor XII (Hageman) Activity
  • Sample TypeBlood
  • Preparations RequiredNo fasting is required. Avoid intense physical activity and notify your doctor if you are on any medications, especially blood thinners.
  • Report Time24 hours

What role does Factor XII play in blood clotting?

Factor XII is involved in the initiation of the intrinsic pathway of blood clotting. It gets activated upon contact with negatively charged surfaces and, in turn, activates other proteins that eventually lead to clot formation.

Why is the Factor XII Activity test important?

This test is important for diagnosing Factor XII deficiency and understanding its impact on the blood clotting process. It is particularly useful when there is an unexplained prolongation of clotting time in laboratory tests.

Home Sample Collection Process

1
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Book your convenient slot
2
Sample Collection by Phlebotomist
Sample Collection by Phlebotomist
3
Reporting of the sample at lab
Reporting of the sample at lab
4
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Frequently Asked Questions

Interestingly, Factor XII deficiency often does not cause noticeable symptoms. Some people may have prolonged clotting times in lab tests without any significant bleeding problems. However, in rare cases, people may experience thrombosis.

As Factor XII deficiency usually does not cause severe bleeding, often no treatment is necessary. For cases where there are complications like thrombosis, anticoagulant medications may be used.

Normal levels of Factor XII activity generally range from 50% to 150% of the laboratory’s reference value.

The test is performed using a blood sample taken from a vein in the arm. The sample is sent to a laboratory where the activity of Factor XII is measured using specialized assays.

Yes, Factor XII deficiency is inherited in an autosomal recessive manner, meaning that an individual must inherit two copies of the defective gene, one from each parent.

Since Factor XII deficiency does not usually cause severe bleeding, specific precautions are not typically necessary. However, individuals should communicate their condition to healthcare professionals when undergoing surgeries or other procedures.

There can be an increased risk of thrombosis or blood clots in some individuals with Factor XII deficiency.

You should consult a hematologist if your Factor XII levels are abnormal.

Yes, blood thinners and certain other medications can affect Factor XII levels. It’s important to inform your doctor about any medications you are taking.

Factor XII deficiency generally does not affect pregnancy, but it’s essential to inform the obstetrician if you have this condition.

The frequency of testing depends on the individual's condition and treatment plan. Your doctor will provide guidance on how often the test should be done.

Lifestyle choices do not significantly impact Factor XII levels, which are primarily influenced by genetics. However, medications such as anticoagulants can modify the levels.

Factor XII deficiency is a genetic condition and cannot be cured. However, it generally does not cause serious health problems, and monitoring by a healthcare professional is usually sufficient.

The Factor XII Activity test is a diagnostic tool for assessing Factor XII deficiency, which is a rare genetic disorder. Understanding your Factor XII levels can help in making informed decisions regarding health and lifestyle. It's important to communicate openly with your doctor and inform them of any medications or medical conditions that may affect the test results. Factor XII deficiency is generally not life-threatening and can be managed effectively through proper communication and monitoring.

FACTOR XII (HAGEMAN) ACTIVITY, SODIUM CITARTE WHOLE BLOOD
₹ 5100
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  • 3KM from Banjara Hills
  • 1.9KM from Yusufguda
  • 3KM from Madhura Nagar
  • 5KM from Shaikpet