Factor 12 (Hageman) Activity Test - Price, Normal Range | Sprint Diagnostics Hyderabad

Patient Preparing : No fasting is required. Avoid intense physical activity and notify your doctor if you are on any medications, especially blood thinners.

₹ 5100


Factor XII, also known as Hageman factor, is a protein that is a part of the blood clotting process. The Factor XII Activity test measures the activity level of Factor XII in your blood and is important for evaluating the intrinsic pathway of the clotting cascade. Factor XII deficiency is a rare genetic disorder that can result in increased bleeding, or in some cases, increased clotting.

The Factor XII Activity test is essential in diagnosing Factor XII deficiency, which is a rare blood disorder. Unlike other clotting factor deficiencies, Factor XII deficiency doesn't always lead to severe bleeding problems but is associated with a prolonged clotting time in laboratory tests. Additionally, Factor XII is involved in inflammatory processes, and its deficiency might have implications beyond clotting.

Test Name Factor XII (Hageman) Activity
Sample Type Blood
Preparations Required No fasting is required. Avoid intense physical activity and notify your doctor if you are on any medications, especially blood thinners.
Report Time 24 hours
Price in Hyderabad ₹ 5100

What role does Factor XII play in blood clotting?

Factor XII is involved in the initiation of the intrinsic pathway of blood clotting. It gets activated upon contact with negatively charged surfaces and, in turn, activates other proteins that eventually lead to clot formation.

Why is the Factor XII Activity test important?

This test is important for diagnosing Factor XII deficiency and understanding its impact on the blood clotting process. It is particularly useful when there is an unexplained prolongation of clotting time in laboratory tests.

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What are the symptoms of Factor XII deficiency?

Interestingly, Factor XII deficiency often does not cause noticeable symptoms. Some people may have prolonged clotting times in lab tests without any significant bleeding problems. However, in rare cases, people may experience thrombosis.

How is Factor XII deficiency managed?

As Factor XII deficiency usually does not cause severe bleeding, often no treatment is necessary. For cases where there are complications like thrombosis, anticoagulant medications may be used.

What are normal levels of Factor XII activity?

Normal levels of Factor XII activity generally range from 50% to 150% of the laboratory’s reference value.

How is the Factor XII Activity test performed?

The test is performed using a blood sample taken from a vein in the arm. The sample is sent to a laboratory where the activity of Factor XII is measured using specialized assays.

Is Factor XII deficiency an inherited condition?

Yes, Factor XII deficiency is inherited in an autosomal recessive manner, meaning that an individual must inherit two copies of the defective gene, one from each parent.

What precautions should individuals with Factor XII deficiency take?

Since Factor XII deficiency does not usually cause severe bleeding, specific precautions are not typically necessary. However, individuals should communicate their condition to healthcare professionals when undergoing surgeries or other procedures.

Are there any complications associated with Factor XII deficiency?

There can be an increased risk of thrombosis or blood clots in some individuals with Factor XII deficiency.

Which doctor should I consult if my Factor XII levels are abnormal?

You should consult a hematologist if your Factor XII levels are abnormal.

Can medications affect Factor XII levels?

Yes, blood thinners and certain other medications can affect Factor XII levels. It’s important to inform your doctor about any medications you are taking.

Can Factor XII deficiency affect pregnancy?

Factor XII deficiency generally does not affect pregnancy, but it’s essential to inform the obstetrician if you have this condition.

How often should the Factor XII Activity test be done?

The frequency of testing depends on the individual's condition and treatment plan. Your doctor will provide guidance on how often the test should be done.

Are there modifiable factors affecting Factor XII levels?

Lifestyle choices do not significantly impact Factor XII levels, which are primarily influenced by genetics. However, medications such as anticoagulants can modify the levels.

Can this condition be cured?

Factor XII deficiency is a genetic condition and cannot be cured. However, it generally does not cause serious health problems, and monitoring by a healthcare professional is usually sufficient.

The Factor XII Activity test is a diagnostic tool for assessing Factor XII deficiency, which is a rare genetic disorder. Understanding your Factor XII levels can help in making informed decisions regarding health and lifestyle. It's important to communicate openly with your doctor and inform them of any medications or medical conditions that may affect the test results. Factor XII deficiency is generally not life-threatening and can be managed effectively through proper communication and monitoring.

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