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Factor XI (Rosenthal) Functional Activity

Factor XI (Rosenthal) Functional Activity

Factor XI, also known as Rosenthal factor, is an enzyme that is an important part of the blood clotting process. Factor XI Functional Activity test is used to assess the activity of Factor XI in the blood, helping to evaluate the blood’s ability to clot properly. This test is particularly vital in diagnosing Factor XI deficiency, also known as hemophilia C, which is a bleeding disorder characterized by reduced levels or activity of Factor XI.

Factor XI deficiency can lead to prolonged bleeding after injury, surgery, or dental procedures. The severity of the bleeding varies among individuals and does not always correlate with Factor XI activity levels. The diagnosis and management of Factor XI deficiency are crucial to prevent excessive bleeding and related complications.

  • Test NameFactor XI (Rosenthal) Functional Activity
  • Sample TypeBlood
  • Preparations RequiredNo fasting is required. Inform your doctor if you are taking any medications, especially blood thinners, as they may affect the results of the test.
  • Report Time24 hours

What is Factor XI?

Factor XI is a protein in the blood that plays a significant role in the coagulation cascade, which is a series of reactions that lead to the formation of blood clots to prevent excessive bleeding.

Why is the Factor XI Functional Activity test important?

This test is important for diagnosing Factor XI deficiency and understanding its severity. It assists doctors in creating a proper management and treatment plan for individuals with bleeding disorders.

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Reporting of the sample at lab
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Frequently Asked Questions

Symptoms may include easy bruising, nosebleeds, bleeding gums, prolonged bleeding from cuts, and excessive bleeding during surgery or dental procedures. Women with Factor XI deficiency may experience heavy menstrual bleeding.

Treatment usually involves replacing the missing Factor XI through plasma infusions, especially before surgical procedures. Antifibrinolytic medications can also be used to help stabilize clots.

Normal levels of Factor XI activity generally range from 65% to 150% of the laboratory’s reference value.

The test is performed using a blood sample drawn from a vein in the arm. The sample is sent to a laboratory where the activity of Factor XI is measured.

Yes, Factor XI deficiency is usually inherited in an autosomal recessive manner, which means both copies of the gene in each cell must have mutations for the disorder to be expressed.

Individuals should avoid activities that have a high risk of injury and bleeding. They should also inform healthcare professionals about their condition before undergoing any surgery or dental procedures.

Complications include an increased risk of bleeding during surgery or after injuries, and in women, heavy menstrual bleeding can lead to anemia.

There is no cure, but the condition can be managed effectively with proper treatment and precautions.

You should consult a hematologist if your Factor XI levels are abnormal.

Yes, individuals with Factor XI deficiency can lead a normal life with proper management and precautions.

No specific dietary restrictions are associated with Factor XI deficiency, but it is always advisable to maintain a balanced diet.

Yes, certain medications such as blood thinners can affect Factor XI levels. It’s important to notify your doctor of any medications you are taking.

The frequency of testing depends on the severity of the condition and the treatment plan. Your doctor will provide guidance on how often the test should be done.

Factor XI is a critical component in the blood clotting process. The Factor XI Functional Activity test is an essential diagnostic tool for assessing the activity of Factor XI and managing bleeding disorders. Through appropriate treatment and careful lifestyle adjustments, individuals with Factor XI deficiency can lead a healthy and active life. Regular communication with your doctor is essential to effectively manage this condition.

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