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Estriol - Unconjugated (uE3)

Estriol - Unconjugated (uE3)

Unconjugated Estriol, commonly abbreviated as uE3, is a type of estrogen that is particularly significant during pregnancy. It is produced by both the fetus and the placenta. The levels of uE3 in the mother's blood can give insights into the well-being of the baby and can be crucial for identifying certain risks and complications in pregnancy.

  • Test NameEstriol - Unconjugated (uE3)
  • Sample TypeBlood
  • Preparations RequiredNo specific preparations are needed for this test. However, it's advisable to inform your doctor about any medications or supplements you are taking, as some might interfere with test results.
  • Report Time6 hours

Why is the Estriol - Unconjugated test done?

The test is often done as part of a series of prenatal screening tests to assess the risk of certain chromosomal abnormalities and congenital anomalies in the fetus, such as Down's syndrome and Edwards syndrome.

How is the test performed?

A blood sample is drawn from a vein in the arm, and the levels of uE3 are measured in a laboratory. The test is usually performed between the 15th and 20th weeks of pregnancy.

Home Sample Collection Process

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Sample Collection by Phlebotomist
Sample Collection by Phlebotomist
Reporting of the sample at lab
Reporting of the sample at lab
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Download Reports
Frequently Asked Questions

Low levels of uE3 could indicate an increased risk of chromosomal abnormalities, such as Down syndrome or neural tube defects. However, abnormal results do not confirm a diagnosis and further testing is required.

The risks are minimal and are mainly associated with the blood draw. This includes slight pain, bruising, or infection at the needle site.

uE3 levels are often used in combination with other tests such as alpha-fetoprotein (AFP), human chorionic gonadotropin (hCG), and inhibin A in a set known as a quadruple screen.

Yes, certain medications including those containing estrogen or used in epilepsy can affect the levels of uE3.

uE3 is significant during pregnancy as it is produced by the placenta and the fetus and its level can be indicative of the health of the fetus.

If your uE3 levels are abnormal, it is important to consult your doctor to discuss the results and understand the implications. Your doctor may recommend additional testing.

No, uE3 levels can vary among different individuals. The levels also change during different stages of pregnancy.

Yes, extremely low levels might indicate an issue with the placenta or fetal adrenal glands.

Normal levels of uE3 can vary based on the lab, the trimester of pregnancy, and individual factors. Your doctor will interpret the results based on specific reference ranges.

No, it is not mandatory. However, it is often recommended as part of routine prenatal screening to assess the health of the fetus.

uE3 alone is not highly accurate in predicting chromosomal abnormalities. It is best used in combination with other tests for a more accurate assessment.

There is no direct evidence to suggest that diet and lifestyle can significantly affect uE3 levels.

If your uE3 levels are abnormal, consult your obstetrician for advice and further evaluation.

uE3 levels is an essential part of prenatal care, especially in evaluating the health and development of the fetus. It is important to know that abnormal uE3 levels do not confirm any diagnosis, but rather indicate the need for further testing and evaluation. Communication with your doctor is key in understanding the results and ensuring the best care during your pregnancy.

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