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Estradiol (E2)

Estradiol (E2)

Estradiol, also known as E2, is the primary female sex hormone. It is a form of estrogen and is primarily produced in the ovaries in women. In men, smaller amounts of estradiol are produced in the testes. This hormone is responsible for the development of female secondary sexual characteristics and regulates the menstrual cycle in women. It also plays a vital role in many other physiological processes in both men and women, including bone health.

  • Test NameEstradiol (E2)
  • Sample TypeBlood
  • Preparations RequiredThere are no special preparations necessary for this test.
  • Report Time6 hours

Why is an Estradiol test performed?

The Estradiol test is performed to measure the levels of estradiol in the blood. It is commonly used in fertility treatment monitoring, in the evaluation of menstrual problems, and in assessing the onset of menopause in women. In men, it may be used to evaluate gynecomastia (enlarged breasts) or to determine the cause of sexual dysfunction.

What does the test involve?

The test involves a simple blood draw from a vein in your arm. The sample is then sent to a laboratory where the level of estradiol is measured.

Home Sample Collection Process

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Sample Collection by Phlebotomist
Sample Collection by Phlebotomist
Reporting of the sample at lab
Reporting of the sample at lab
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Download Reports
Frequently Asked Questions

High levels of estradiol in women could indicate early puberty, tumors, or abnormal functioning of the ovaries or adrenal glands. In men, high levels could indicate feminization, which could be due to conditions like liver disease, a tumor, or drug abuse. Low levels in women could suggest menopause, poor ovarian function, or anorexia nervosa, while in men, it could suggest a decrease in testicular function.

In women, symptoms might include irregular or absent periods, hot flashes, mood swings, vaginal dryness, or difficulty getting pregnant. In men, symptoms might include gynecomastia, infertility, or sexual dysfunction.

The risks associated with a blood draw are minimal, including slight pain or bruising at the site of the needle prick.

Yes, certain medications can affect estradiol levels. These include hormonal contraceptives, hormone therapy, antibiotics, and certain psychiatric medications.

No special preparation is needed for the estradiol test.

Yes, even though estradiol is commonly thought of as a female hormone, it is important for men as well. It helps regulate libido, erectile function, and the production of sperm.

Yes, estradiol plays a key role in the regulation of the menstrual cycle and the development of eggs in the ovaries. It is also important for maintaining pregnancy.

Yes, estradiol levels can fluctuate throughout the day, and in women, they can also vary throughout the menstrual cycle.

Normal levels depend on your sex, age, and for women, the stage of the menstrual cycle. The lab report will usually provide a reference range.

Factors that can affect estradiol levels include age, sex, medications, health of your ovaries or testes, and overall health.

Yes, obesity, alcohol consumption, and having a diet high in phytoestrogens (found in foods like soy) can affect estradiol levels.

Yes, estradiol can affect mood, particularly in women. Some women may experience mood swings, anxiety, or depression due to fluctuating estradiol levels during their menstrual cycle or menopause.

If your estradiol levels are abnormal, you should consult your primary care doctor, who may refer you to an endocrinologist or a gynecologist if you are a woman.

Monitoring and understanding estradiol levels can be essential for both women and men, especially those dealing with fertility issues, hormonal imbalances, or transitioning into menopause. It is important to interpret the results in conjunction with other tests and clinical evaluations, and to discuss them thoroughly with your doctor to ensure appropriate medical guidance and care.

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