Cortisol Suppression by Dexamethasone | Overnight High Dose Test - Price, Normal Range | Sprint Diagnostics Hyderabad

Patient Preparing : The test requires taking dexamethasone, usually at 11 p.m., and having blood drawn the next morning at 8 a.m. It's essential to take the dexamethasone exactly as instructed and avoid any additional medications unless approved by the doctor.

₹ 1155


The Cortisol Suppression by Dexamethasone, Overnight High Dose Test, commonly known as the Overnight Dexamethasone Suppression Test, is a diagnostic procedure used to check for Cushing's syndrome, a condition characterized by excessive cortisol levels. Cortisol is a hormone produced by the adrenal glands, and it plays a crucial role in various bodily functions, such as metabolism, immune response, and stress management.

Dexamethasone is a medication that typically suppresses cortisol production in healthy individuals. In this test, a high dose of dexamethasone is administered, and cortisol levels are measured the following morning. If the cortisol levels do not decrease significantly, it might indicate the presence of Cushing's syndrome or another disorder affecting cortisol production.

Test Name Cortisol Suppression by Dexamethasone, Overnight High Dose Test
Sample Type Blood
Preparations Required The test requires taking dexamethasone, usually at 11 p.m., and having blood drawn the next morning at 8 a.m. It's essential to take the dexamethasone exactly as instructed and avoid any additional medications unless approved by the doctor.
Report Time 6 hours
Price ₹ 1155

What is the Cortisol Suppression by Dexamethasone, Overnight High Dose Test?

This test involves taking a high dose of dexamethasone to suppress cortisol production and measuring cortisol levels the next morning. It is used to check for disorders affecting cortisol production, primarily Cushing's syndrome.

How is this test performed?

The test requires taking a high dose of dexamethasone, usually at 11 p.m., and having blood drawn the next morning at 8 a.m. for cortisol measurement.

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Why is this test important?

This test is crucial for diagnosing Cushing's syndrome and other conditions involving abnormal cortisol production. Early diagnosis and treatment are vital for managing symptoms and preventing complications.

What does it mean if cortisol levels do not decrease after taking dexamethasone?

If cortisol levels do not significantly decrease after taking dexamethasone, it may indicate Cushing's syndrome or another disorder affecting cortisol production.

Are there any risks associated with this test?

The risks are minimal but may include slight pain or bruising at the blood draw site. There are also potential side effects from taking dexamethasone, such as nausea or difficulty sleeping.

What should I do before the test?

Follow your doctor’s instructions on taking dexamethasone, avoid taking other medications unless approved by your doctor, and make sure to have your blood drawn at the specified time.

Can medications interfere with the results of the test?

Yes, certain medications can affect cortisol levels or interact with dexamethasone. Inform your doctor about all medications and supplements you are taking.

Which doctor should be consulted in case of abnormal test results?

An endocrinologist should be consulted in case of abnormal test results.

How is Cushing's syndrome treated if diagnosed?

Treatment for Cushing's syndrome varies depending on the cause and may include surgery, radiation, medications, or a combination of these.

What are some symptoms of Cushing's syndrome?

Some common symptoms of Cushing's syndrome include weight gain, fatty deposits around the face and abdomen, thinning skin, and easy bruising.

Can stress affect the results of this test?

Chronic stress can elevate cortisol levels, so it is essential to manage stress and inform your doctor if you have been under significant stress.

What are some other tests for diagnosing Cushing's syndrome?

Other tests that can help diagnose Cushing's syndrome include 24-hour urinary free cortisol test, late-night salivary cortisol test, and low-dose dexamethasone suppression test.

Can this test be used to monitor the effectiveness of treatment for Cushing's syndrome?

Yes, this test can be used to monitor cortisol levels and evaluate the effectiveness of treatment for Cushing's syndrome.

What are the normal cortisol levels after taking a high dose of dexamethasone?

Normally, cortisol levels should be significantly lower after taking a high dose of dexamethasone. However, normal values can vary, so it’s important to discuss the results with your doctor.

Can I drink water before the test?

Yes, you can and should stay hydrated. However, avoid consuming any caffeinated beverages.

The Cortisol Suppression by Dexamethasone, Overnight High Dose Test is an essential diagnostic tool for evaluating disorders related to cortisol production, primarily Cushing's syndrome. Proper preparation, including adhering to medication schedules and communicating with your doctor, is crucial for accurate results. Understanding the significance of this test and interpreting the results with the assistance of your doctor can lead to early diagnosis and effective management of any underlying conditions.

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