Coombs Test - Indirect with Reflex Antibody Screening (3 Cell Panel)

This test combines the Indirect Coombs Test with additional antibody screening using a panel of red blood cells from three different donors. It detects and identifies antibodies in the plasma that may react with red blood cell antigens, which is vital for ensuring blood transfusion compatibility and managing certain pregnancy conditions.

A blood sample is taken and the plasma is separated. The plasma is then mixed with red blood cells from three different donors in the presence of a special reagent. If antibodies are present in the plasma, they will bind to the red blood cells. Further tests are carried out to identify the specific antibodies.

A positive result indicates the presence of antibodies in the plasma that can react with red blood cell antigens. This is important to know before a blood transfusion or during pregnancy to prevent adverse reactions.

A negative result suggests that there are no detectable antibodies in the plasma that would react with the red blood cells, indicating compatibility for transfusion.

Identifying specific antibodies is vital for selecting compatible blood for transfusion and for understanding risks during pregnancy, such as hemolytic disease of the newborn due to maternal antibodies.

The risks are minimal and similar to those of a regular blood draw, such as slight pain, bruising, or bleeding at the site where the needle is inserted.

Yes, this test is used during pregnancy to screen for antibodies that might affect the fetus, especially in cases of Rh incompatibility.

The basic Indirect Coombs Test only detects the presence of antibodies in the plasma, while this test also identifies the specific antibodies present using a 3 cell panel for more comprehensive screening.

Using a 3 cell panel enhances the screening process by testing the plasma against red blood cells from three different donors. This offers a broader scope for identifying various antibodies.

Certain medications can affect the results. It’s important to inform your doctor about all medications and supplements you are taking.

If the test is positive, a hematologist or a doctor specializing in blood disorders should be consulted. Pregnant women may also need to consult their obstetrician.

Yes, the Coombs Test with Reflex Antibody Screening can be used to monitor the levels of antibodies, helping evaluate the effectiveness of treatment for autoimmune hemolytic anemia.

The Indirect Coombs Test with Reflex Antibody Screening using a 3 Cell Panel is a highly sensitive and comprehensive test for detecting and identifying antibodies in the plasma that can react with red blood cell antigens. It is invaluable in ensuring the safety and compatibility of blood transfusions and in managing pregnancies where there is a risk of complications due to maternal antibodies. It is important for patients to consult their doctor for proper interpretation and appropriate guidance based on the results.