Coombs Test Direct (Gel Agglutination) - Price, Normal Range | Sprint Diagnostics Hyderabad

Patient Preparing : No fasting or specific preparation is required

₹ 600


The Coombs Test, specifically the Direct Coombs Test using Gel Agglutination, is a blood test used to detect antibodies that are bound to the surface of red blood cells. The test is often used to help diagnose and monitor conditions such as hemolytic anemia, where the body’s immune system destroys its own red blood cells, and to investigate the cause of jaundice in newborns. It’s also essential in the context of blood transfusion reactions.

In the Direct Coombs Test using Gel Agglutination, a blood sample is taken and mixed with a special gel containing anti-human globulin. This substance causes red blood cells with attached antibodies to clump together, and this clumping can be detected under a microscope. Gel Agglutination is a highly sensitive method, which allows for more precise detection of antibodies compared to traditional techniques.

Test Name Coombs Test - Direct (Gel Agglutination)
Sample Type Blood
Preparations Required No fasting or specific preparation is required.
Report Time 6 hours
Price ₹ 600

What is the purpose of the Direct Coombs Test?

The Direct Coombs Test is used to detect the presence of antibodies bound to the surface of red blood cells. It's essential in diagnosing conditions such as autoimmune hemolytic anemia, in investigating hemolytic disease of the newborn, and in evaluating transfusion reactions.

How is the Direct Coombs Test performed using Gel Agglutination?

In this method, a blood sample is mixed with a special gel containing anti-human globulin. If antibodies are bound to the red blood cells, they will clump together in the gel. This clumping is then detected under a microscope.

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What does a positive Direct Coombs Test indicate?

A positive result indicates that there are antibodies attached to the red blood cells. This could be due to autoimmune hemolytic anemia, hemolytic disease of the newborn, or a reaction to a blood transfusion.

What does a negative Direct Coombs Test indicate?

A negative result means that no antibodies are attached to the red blood cells, and it is unlikely that the individual has autoimmune hemolytic anemia or other conditions associated with antibodies bound to red blood cells.

Are there any risks or side effects associated with the Direct Coombs Test?

The risks associated with the Direct Coombs Test are minimal and similar to those of a regular blood draw, such as slight pain, bruising, or bleeding at the site where the needle is inserted.

Can medication interfere with the results of the Direct Coombs Test?

Yes, certain medications can interfere with the results of the test. It’s important to inform your doctor about all medications and supplements you are taking.

Is the Direct Coombs Test used during pregnancy?

Yes, the Direct Coombs Test can be used during pregnancy to detect antibodies that may affect the fetus, especially in cases of Rh incompatibility between the mother and fetus.

What is the difference between the Direct Coombs Test and the Indirect Coombs Test?

The Direct Coombs Test detects antibodies bound to the red blood cells in the patient’s blood. The Indirect Coombs Test, on the other hand, detects antibodies in the plasma that can bind to red blood cells.

Can the Direct Coombs Test be used to monitor the treatment of autoimmune hemolytic anemia?

Yes, the test can be used to monitor the presence of antibodies on red blood cells over time, which can help in evaluating the effectiveness of treatment for autoimmune hemolytic anemia.

What is hemolytic disease of the newborn?

Hemolytic disease of the newborn is a condition where a mother's antibodies attack the red blood cells of the fetus, leading to anemia in the newborn. The Direct Coombs Test is used to investigate this condition.

Which doctor should be consulted in case of a positive Direct Coombs Test?

If the Direct Coombs Test is positive, it is advisable to consult a hematologist for further evaluation and guidance regarding the underlying cause and appropriate management.

Is Gel Agglutination more effective than other methods for the Direct Coombs Test?

Gel Agglutination is considered to be more sensitive and precise compared to the traditional tube method. It allows for the detection of smaller quantities of antibodies, making it more effective in certain cases.

Can the Direct Coombs Test detect all types of hemolytic anemia?

No, the Direct Coombs Test specifically detects immune-mediated hemolytic anemia, where antibodies are involved. It does not detect other types of hemolytic anemia that result from different causes.

How will my doctor interpret the results of the Direct Coombs Test?

Your doctor will interpret the results in the context of your medical history, symptoms, and other laboratory tests. The presence or absence of antibodies on red blood cells will guide further management and treatment decisions.

The Direct Coombs Test using Gel Agglutination is an essential diagnostic tool for detecting antibodies bound to red blood cells. This test is pivotal in the diagnosis and management of conditions like autoimmune hemolytic anemia, hemolytic disease of the newborn, and in evaluating blood transfusion reactions. A positive result indicates the presence of antibodies on red blood cells, which can be associated with various conditions. It is important to consult a doctor for proper interpretation of the results and guidance on the appropriate next steps.

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