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CLL smart 2

CML Quant: Chronic Myeloid Leukemia with Karyotyping and BCR/ABL - IS by PCR Quantitative

Chronic Myeloid Leukemia (CML) is a form of leukemia characterized by the abnormal growth of myeloid cells in the bone marrow and their accumulation in the blood. CML is a genetic disease and is most often associated with a specific chromosomal abnormality known as the Philadelphia chromosome. The Philadelphia chromosome arises from a reciprocal translocation between chromosomes 9 and 22, which results in the BCR-ABL fusion gene. The protein produced by this gene is a tyrosine kinase that promotes cell proliferation, contributing to the development of leukemia.

CML Quant is a testing approach that includes Karyotyping and BCR/ABL International Scale (IS) by Polymerase Chain Reaction (PCR) Quantitative. Karyotyping is used to visualize the chromosomes in the cells, which can confirm the presence of the Philadelphia chromosome. BCR/ABL - IS by PCR Quantitative is a highly sensitive method that measures the levels of the BCR-ABL fusion gene and is used to monitor the patient’s response to therapy over time.


  • Test NameCML Quant: Chronic Myeloid Leukemia with Karyotyping and BCR/ABL - IS by PCR Quantitative
  • Sample TypeBlood/Bone Marrow
  • Preparations RequiredNo fasting is required. It is crucial to adhere to any instructions given by your doctor, and to inform them of any medications being taken.
  • Report Time10 Days for cytogenetics / 5 Days for PCR.

What is Chronic Myeloid Leukemia (CML)?

Chronic Myeloid Leukemia is a type of cancer that starts in the blood-forming cells in the bone marrow. It is characterized by the uncontrolled growth of myeloid cells in the bone marrow and their accumulation in the blood. CML is associated with a specific genetic abnormality called the Philadelphia chromosome.

What is the role of Karyotyping in CML diagnosis?

Karyotyping is a laboratory procedure that allows for the visualization of an individual's chromosomes. In CML, karyotyping is important for the identification of the Philadelphia chromosome, which is a hallmark of this disease.

Home Sample Collection Process

1
Book your convenient slot
Book your convenient slot
2
Sample Collection by Phlebotomist
Sample Collection by Phlebotomist
3
Reporting of the sample at lab
Reporting of the sample at lab
4
Download Reports
Download Reports
Frequently Asked Questions

BCR/ABL - IS by PCR Quantitative measures the amount of BCR-ABL fusion gene in blood or bone marrow. This test is highly sensitive and is used to monitor how well a patient with CML is responding to treatment.

Measurement of the BCR/ABL fusion gene is important for the diagnosis and monitoring of CML. It helps to confirm the diagnosis and to evaluate how well the disease is responding to treatment. Additionally, it can be used to detect minimal residual disease in patients in remission.

The frequency of CML Quant testing depends on the stage of the disease and how well the patient is responding to treatment. It is usually done at diagnosis and regularly thereafter to monitor the response to therapy.

The primary treatment for CML is tyrosine kinase inhibitors, which target the BCR-ABL protein. Other treatments may include chemotherapy, bone marrow transplantation, and immunotherapy.

Patients with CML should maintain a balanced diet, engage in regular physical activity, avoid tobacco and limit alcohol consumption. It is also important to adhere to the treatment regimen and follow-up appointments as recommended by the doctor.

While CML can often be controlled with medication, especially if diagnosed early, it may not be curable in all patients. However, some patients may achieve a deep molecular response, which means that the disease is not detectable with the most sensitive tests.

CML treatments, particularly tyrosine kinase inhibitors, can have side effects such as fatigue, nausea, muscle cramps, and changes in blood counts. It is important to communicate with the doctor about any side effects experienced during treatment.

If diagnosed with Chronic Myeloid Leukemia, it is essential to consult a hematologist or oncologist who specializes in the treatment of blood cancers.

Yes, there are support groups and organizations that offer help and support to individuals with CML and their families.

CML is not typically hereditary. It is caused by a genetic change that occurs during a person’s lifetime.

CML Quant testing is a comprehensive approach to the diagnosis and monitoring of Chronic Myeloid Leukemia. Karyotyping helps in identifying the Philadelphia chromosome, while BCR/ABL - IS by PCR Quantitative measures the level of the BCR-ABL fusion gene to monitor the response to treatment. Regular monitoring and adherence to the treatment regimen are vital in managing CML. Communication with the treating doctor is imperative for comprehensive care and management.

CML Quant (Karyotyping and BCR/ABL - IS By PCR Quantitative)
₹ 10000
Schedule Test in Your Available Time
Locations Near You in Hyderabad
  • 4KM from Madhapur
  • 3KM from Banjara Hills
  • 1.9KM from Yusufguda
  • 3KM from Madhura Nagar
  • 5KM from Shaikpet