Chronic Lymphocytic Leukemia smart 2Test, Price, Normal Range | Sprint Diagnostics Hyderabad

Patient Preparing : No fasting is required. However, it is advisable to inform your doctor of any medications or supplements you are taking.

₹ 22000


Chronic Lymphocytic Leukemia (CLL) is a type of blood cancer that affects the white blood cells and is characterized by the accumulation of abnormal lymphocytes. CLL Smart 2 is a comprehensive diagnostic test that combines Flow Cytometry (FCM) with Fluorescence In Situ Hybridization (FISH) to analyze multiple genetic markers - 17p deletion, ATM deletion, Trisomy 12, and 13q deletion. This combination of analyses is vital in diagnosing CLL, assessing its severity, and providing insights for personalized treatment plans.

Flow Cytometry is a technique that is employed to analyze the physical and chemical properties of cells in a fluid as it passes through one or more lasers. FISH is used to detect chromosome changes and can be especially important in identifying chromosomal deletions and mutations that are associated with various forms of CLL. Identifying these genetic abnormalities is essential for determining prognosis and guiding treatment strategies.

Test Name CLL Smart 2 (FCM CLL Panel and FISH For 17p , ATM Del , Trisomy 12 and Del13q)
Sample Type Blood/ bone marrow
Preparations Required No fasting is required. However, it is advisable to inform your doctor of any medications or supplements you are taking.
Report Time 12 days
Price in Hyderabad ₹ 22000

What is CLL Smart 2 test?

CLL Smart 2 is an advanced diagnostic test that combines Flow Cytometry (FCM) CLL Panel with Fluorescence In Situ Hybridization (FISH) to analyze multiple genetic markers - 17p deletion, ATM deletion, Trisomy 12, and 13q deletion - in patients with Chronic Lymphocytic Leukemia (CLL).

Why is CLL Smart 2 important?

CLL Smart 2 is critical because it helps in the diagnosis of CLL and provides information regarding several genetic markers that can impact the course of the disease and its response to treatment. This information is invaluable for doctors to make informed treatment decisions.

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What genetic markers does CLL Smart 2 test for?

CLL Smart 2 tests for 17p deletion, ATM deletion, Trisomy 12, and 13q deletion. These markers have different prognostic implications and can affect the selection of treatment modalities.

How is the CLL Smart 2 test performed?

A blood sample is drawn from the patient. This sample is then processed using Flow Cytometry to analyze the physical and chemical properties of lymphocytes and Fluorescence In Situ Hybridization (FISH) to analyze chromosomal abnormalities.

What is the significance of the genetic markers that CLL Smart 2 tests for?

17p deletion is associated with an aggressive form of CLL and resistance to chemotherapy. ATM deletion is associated with an intermediate prognosis. Trisomy 12 can indicate a variable course. 13q deletion is typically associated with a more favorable prognosis. These markers help in predicting the course of CLL and guiding treatment strategies.

What does it mean if any of these genetic markers are present?

The presence of these genetic markers can indicate the likely course of the disease and response to treatment. For example, 17p deletion often indicates an aggressive form and resistance to standard chemotherapy. This information is essential in guiding the choice of treatment.

What are the treatment options if any of these genetic markers are present?

Treatment options vary depending on the genetic markers present. For example, patients with 17p deletion might benefit from targeted therapies. The choice of treatment should be personalized based on the genetic profile of the CLL and the health status of the patient.

What role does Flow Cytometry play in this test?

Flow Cytometry is used to analyze the physical and chemical characteristics of cells in CLL. It can help to accurately diagnose CLL by determining the numbers and types of lymphocytes and other white blood cells.

How can FISH contribute to the CLL Smart 2 test?

FISH, or Fluorescence In Situ Hybridization, detects specific DNA sequences in CLL cells. It is essential in identifying chromosomal abnormalities such as deletions and mutations that can have prognostic implications.

Do I need to do anything to prepare for the test?

No special preparation is needed for the CLL Smart 2 test. However, you should inform your doctor of any medications or supplements you are taking, as they might affect the test results.

What type of doctor should I consult if I have an abnormal CLL Smart 2 result?

If the CLL Smart 2 test results are abnormal, it is important to consult a hematologist or oncologist who specializes in blood cancers, including CLL.

Can lifestyle changes impact CLL?

While lifestyle changes cannot cure CLL, a healthy lifestyle including a balanced diet, regular exercise, and avoiding tobacco and excessive alcohol can improve overall health and may be beneficial in managing CLL.

What is the future outlook for patients with CLL and particular genetic markers?

The outlook for patients with CLL can vary widely depending on the genetic markers present. Advances in targeted therapies and personalized medicine continue to improve the outlook for many patients with CLL

CLL Smart 2 is an advanced, comprehensive diagnostic tool that combines Flow Cytometry and FISH analysis for multiple genetic markers in CLL. This test is invaluable in diagnosing CLL, understanding its genetic characteristics, and guiding individualized treatment plans. Having an in-depth discussion with your doctor about the results and following an appropriate treatment regimen is vital for managing CLL effectively.

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