Chronic Lymphocytic Leukemia smart 1 Test, Price, Normal Range | Sprint Diagnostics Hyderabad

Patient Preparing : No fasting is required. It is recommended to inform your doctor of any medications or supplements you are taking.

₹ 14500


Chronic Lymphocytic Leukemia (CLL) is a blood cancer that affects white blood cells, particularly lymphocytes, and gradually leads to their increase in number. The CLL Smart 1 test combines Flow Cytometry (FCM) with Fluorescence In Situ Hybridization (FISH) to specifically analyze for the 17p deletion. This comprehensive analysis helps in diagnosing CLL, evaluating its severity, and guiding personalized treatment strategies.

Flow Cytometry (FCM) is a technology that is used to analyze the physical and chemical characteristics of particles in a fluid as it passes through at least one laser. Cell components are fluorescently labeled and then excited by the laser to emit light at varying wavelengths. On the other hand, FISH for 17p deletion is crucial as it's associated with resistance to chemotherapy and a more aggressive form of CLL.

Test Name CLL Smart 1: Flow Cytometry (FCM) CLL Panel and FISH for 17p
Sample Type Blood/bone marrow
Preparations Required No fasting is required. It is recommended to inform your doctor of any medications or supplements you are taking.
Report Time 12 days
Price in Hyderabad ₹ 14500

What is the CLL Smart 1 test?

CLL Smart 1 is an advanced diagnostic test that combines Flow Cytometry (FCM) CLL panel with Fluorescence In Situ Hybridization (FISH) to specifically analyze for the 17p deletion in patients with Chronic Lymphocytic Leukemia (CLL).

Why is this test important?

This test is essential because it not only helps in diagnosing CLL but is also instrumental in guiding treatment decisions. The 17p deletion is associated with a more aggressive form of CLL and resistance to standard chemotherapy, so knowing its presence can help in tailoring the most effective treatment strategy.

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What does FCM CLL Panel detect?

FCM CLL Panel uses flow cytometry to detect abnormal lymphocytes. It helps in diagnosing CLL and can differentiate it from other lymphoproliferative disorders. It also provides information about the expression of different surface markers on lymphocytes.

What is the significance of the 17p deletion in CLL?

The 17p deletion involves the loss of the TP53 gene which is important for controlling cell division and apoptosis. Patients with the 17p deletion typically have a more aggressive disease course and are often resistant to standard chemotherapy.

How is the CLL Smart 1 test performed?

A blood sample is taken from the patient. Flow Cytometry is used to analyze surface markers on lymphocytes, and FISH is used to detect the 17p deletion by using fluorescent probes that bind to parts of the chromosomes.

What does it mean if the 17p deletion is detected?

If the 17p deletion is detected, it means that CLL may have an aggressive course and that standard chemotherapy may not be effective. It indicates the need for alternate treatment strategies.

Are there any special preparations needed for the test?

There are no special preparations needed for this test. It is, however, advisable to inform your doctor about any medications or supplements you are taking.

Can this test be used to monitor the progression of CLL?

Yes, this test can be used to monitor the progression of CLL, especially if it was found to have the 17p deletion. It helps in monitoring how the disease is responding to the treatment and if there are any changes in the cancer cells.

What are the treatment options if the 17p deletion is present?

Patients with the 17p deletion may be treated with targeted therapies such as ibrutinib or a combination of drugs, instead of standard chemotherapy. Stem cell transplantation might be another option for some patients.

Is CLL curable?

CLL is not considered curable with the current treatments available. However, with appropriate treatment, many individuals with CLL can manage the disease as a chronic condition.

Is there any way to prevent CLL?

There is no known way to prevent CLL. The risk of developing CLL is associated with age, family history, and exposure to certain chemicals.

What are the symptoms of CLL?

Common symptoms of CLL include fatigue, swollen lymph nodes, weight loss, frequent infections, and easy bruising or bleeding.

How often should this test be done?

The frequency of this test is based on the doctor’s recommendations, usually at diagnosis and at various points during treatment, especially if there’s a change in health status or if considering a stem cell transplant.

Which doctor should be consulted in case of an abnormal value?

In case of abnormal values, a hematologist or an oncologist should be consulted. They specialize in blood disorders and cancer respectively.

What is the role of lifestyle in managing CLL?

A healthy lifestyle is important in managing CLL. This includes a balanced diet, regular exercise, and avoiding tobacco and excessive alcohol. Stress management is also important.

Understanding the nature of Chronic Lymphocytic Leukemia, particularly in the context of the 17p deletion, can be fundamental in managing the condition effectively. The CLL Smart 1 test is an essential tool that aids in diagnosis, monitoring, and guiding treatment decisions. Keeping an open dialogue with your doctor, understanding the results, and complying with the prescribed treatment regimen is integral in navigating CLL.

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