CLL extended 4

CLL FISH 2: Chronic Lymphocytic Leukemia with FISH for del17p, del11q (ATM Deletion), Trisomy 12, and del13q

Chronic Lymphocytic Leukemia (CLL) is a type of cancer that affects white blood cells and can impact the body’s ability to fight infection. To optimize the treatment strategy, it's essential to understand the genetic makeup of CLL cells. The CLL FISH 2 test uses Fluorescence In Situ Hybridization (FISH) to analyze and detect specific chromosomal abnormalities including deletion 17p (del17p), deletion 11q (ATM deletion), Trisomy 12, and deletion 13q (del13q). These abnormalities are important in determining the aggressiveness of CLL and guiding the therapeutic decisions.

The CLL FISH 2 test plays a pivotal role in the characterization of CLL by providing detailed information on genetic abnormalities. This is vital for determining the prognosis and selecting appropriate treatment strategies for patients with CLL.

  • Test NameCLL FISH 2: Chronic Lymphocytic Leukemia with FISH for del17p, del11q (ATM Deletion), Trisomy 12, and del13q
  • Sample TypeBlood/bone marrow
  • Preparations RequiredNo fasting is required. Inform your doctor of any medications or supplements you are taking.
  • Report Time5 days

What is the CLL FISH 2 test?

CLL FISH 2 is a diagnostic test that uses Fluorescence In Situ Hybridization (FISH) to analyze and detect specific chromosomal abnormalities in cells affected by Chronic Lymphocytic Leukemia. This test focuses on identifying deletion 17p, deletion 11q (ATM deletion), Trisomy 12, and deletion 13q.

Why is this test important?

This test is important for diagnosing CLL, assessing its severity, and guiding treatment decisions. Different chromosomal abnormalities are associated with varying disease courses and responses to treatment. Identifying these abnormalities helps in tailoring treatment accordingly.

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Frequently Asked Questions

Del17p is associated with resistance to standard chemotherapy and has a poor prognosis. Del11q indicates advanced disease and rapid progression. Trisomy 12 is an extra copy of chromosome 12 and has a variable prognosis. Del13q is generally associated with a more favorable prognosis compared to other abnormalities.

FISH stands for Fluorescence In Situ Hybridization. It is a technique used to detect and locate specific DNA sequences on chromosomes. It is highly sensitive and specific for identifying chromosomal abnormalities such as deletions or extra copies, which are crucial in understanding CLL.

No special preparation is required for this test. However, it is essential to inform your doctor about any medications or supplements you are taking as these might affect the test results.

No, fasting is not required for this test.

This test is usually performed at the time of diagnosis. It may also be repeated if there is a change in clinical status or if new treatment options are being considered.

In normal cells, del17p, del11q, Trisomy 12, and del13q are not present. The presence of these abnormalities in CLL cells is indicative of chromosomal aberrations.

In case of abnormal results, a hematologist or oncologist specializing in blood cancers should be consulted.

The stage of CLL, ongoing treatment, and the quality of the blood sample can affect the test results. Additionally, technical factors in the laboratory can also have an impact.

Treatment options for CLL vary depending on the stage and genetic characteristics of the disease. They include chemotherapy, targeted therapy, immunotherapy, and, in certain cases, stem cell transplantation.

There are few known modifiable risk factors for CLL. However, leading a healthy lifestyle, avoiding exposure to certain chemicals, and maintaining regular check-ups can help in early detection.Can CLL be cured?

Currently, there is no cure for CLL. However, treatment can often help in managing the condition effectively.

Stem cell transplantation may be an option for certain patients with CLL, particularly those with high-risk forms of the disease or those who do not respond to other treatments. This option should be discussed with the doctor.

Being informed and proactive in understanding the intricacies of Chronic Lymphocytic Leukemia, especially with respect to its genetic aspects, is imperative. CLL FISH 2 test is a significant step in not only diagnosing the condition but also in charting out a personalized and effective treatment plan. Understanding your test results, and engaging in discussions with your doctor can prove vital in your journey through CLL.

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