Chronic Lymphocytic Leukemia Fish 1Test, Price, Normal Range | Sprint Diagnostics Hyderabad
Patient Preparing : No fasting is required. Inform your doctor of any medications or supplements you are taking.
Chronic Lymphocytic Leukemia (CLL) is a type of blood cancer that primarily affects white blood cells. The CLL FISH 1 test is a specialized diagnostic test that employs Fluorescence In Situ Hybridization (FISH) to analyze the genetic material in the blood cells affected by CLL. The test particularly looks for chromosomal abnormalities including deletion 17p (del17p), deletion 11q (ATM deletion), and Trisomy 12. These genetic markers are of paramount importance in understanding the complexity and severity of CLL, and in developing a tailor-made treatment approach.
The CLL FISH 1 test is particularly essential in pinpointing chromosomal aberrations that may be responsible for the development or progression of CLL. By detecting the deletion of chromosomes 17p and 11q, as well as Trisomy 12, this test plays a critical role in predicting the prognosis and guiding the therapeutic decisions for CLL.
|CLL FISH 1:Chronic Lymphocytic Leukemia with FISH for del17p, del11q (ATM Deletion), and Trisomy 12
|No fasting is required. Inform your doctor of any medications or supplements you are taking.
|Price in Hyderabad
What is the CLL FISH 1 test?
CLL FISH 1 is a diagnostic test that uses Fluorescence In Situ Hybridization (FISH) to analyze and detect specific chromosomal abnormalities in cells affected by Chronic Lymphocytic Leukemia. It focuses on identifying deletion 17p, deletion 11q (ATM deletion), and Trisomy 12.
Why is FISH used in this test?
FISH is used because it is a highly sensitive and specific method for detecting chromosomal abnormalities at a DNA level. It helps in visualizing specific DNA sequences on chromosomes and is instrumental in identifying deletions or additional copies of chromosomes, which can be critical in CLL.
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How does this test help in managing CLL?
This test is essential in the management of CLL as it helps in predicting the course of the disease. For instance, deletion 17p is known to be associated with a poor response to certain chemotherapy drugs. Identifying these chromosomal abnormalities allows the doctor to choose the most appropriate treatment.
What is the significance of deletion 17p, deletion 11q, and Trisomy 12?
Deletion 17p is associated with a more aggressive form of CLL and resistance to standard chemotherapy. Deletion 11q signifies a more advanced disease and may be associated with rapid progression. Trisomy 12 is an extra copy of chromosome 12 and is associated with variable prognosis.
Do I need to prepare in any way for this test?
No specific preparation is needed. However, it's important to inform your doctor about any medications or supplements you are taking.
How often should this test be done?
The frequency of this test depends on various factors including the stage of CLL, the patient’s response to treatment, and the doctor’s recommendations. It may be conducted at diagnosis, before starting a new treatment, or to monitor the course of the disease.
What are normal values for this test?
In normal cells, deletion 17p, deletion 11q, and Trisomy 12 are not present. The presence of these abnormalities in CLL cells indicates a chromosomal aberration.
What doctor should I consult if the test results are abnormal?
If the test results are abnormal, it is advisable to consult a hematologist or an oncologist who specializes in blood cancers.
What factors might affect the test results?
Technical errors and quality of the blood sample can affect the test results. The stage of the disease and any ongoing treatment may also have an impact.
Can CLL be cured?
As of now, CLL is considered a chronic disease. While there is no cure, it can often be managed effectively with treatment. Advances in therapy continue to improve the outlook for individuals with CLL.
Are there any risks associated with this test?
The test involves a simple blood draw, and risks are minimal. These might include slight pain or bruising at the site where the needle was inserted.
What are modifiable and non-modifiable factors that affect CLL?
Non-modifiable factors include age, gender, and genetics. Modifiable factors include exposure to certain chemicals and maintaining a healthy lifestyle.
Is there any role for a bone marrow transplant in CLL?
Bone marrow transplant may be considered in some cases of CLL, especially for younger patients or those with a high-risk form of the disease. The suitability of a bone marrow transplant should be discussed with the doctor.
The CLL FISH 1 test is an essential component in the arsenal against Chronic Lymphocytic Leukemia. Its ability to detect chromosomal abnormalities provides invaluable information that can dictate the course of management and treatment. Armed with the knowledge that this test provides, doctors are better equipped to offer targeted therapies and interventions that can greatly improve the quality of life for individuals with CLL. Understanding your test and being proactive in communication with your doctor can significantly impact the journey through CLL.
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