Chronic Lymphocytic Leukemia Cytogenetics 1 Test, Price, Normal Range | Sprint Diagnostics Hyderabad

Patient Preparing : No fasting required. It is advised to inform your doctor about any medications you are taking.

₹ 8000

Chronic Lymphocytic Leukemia (CLL) is a type of cancer that begins in the bone marrow and leads to the production of abnormal lymphocytes, a type of white blood cell. With time, these abnormal cells accumulate and can impede the bone marrow's ability to produce healthy blood cells. CLL Cytogenetics 1 is an advanced diagnostic test that combines Karyotyping and Fluorescence In Situ Hybridization (FISH) to specifically detect deletion in chromosome 17p (del17p), an abnormality which is often associated with CLL. The presence of del17p is known to be indicative of a more aggressive form of CLL and can have a significant impact on treatment decisions and prognosis.

Karyotyping is a lab test that helps in visualizing an individual's chromosomes, whereas FISH uses fluorescent probes to detect specific DNA sequences, and in this context, it is used to identify the deletion in chromosome 17p. Understanding the genetic makeup of CLL through these tests is an important step in determining the most effective treatment plan.What is Chronic Lymphocytic Leukemia (CLL)?

Test Name CLL Cytogenetics 1 (Karyotyping + FISH for del17p)
Sample Type Blood/bone marrow
Preparations Required No fasting required. It is advised to inform your doctor about any medications you are taking.
Report Time 12 Days for Karyotype & 5 Days for FISH
Price in Hyderabad ₹ 8000

What is Chronic Lymphocytic Leukemia (CLL)?

Chronic Lymphocytic Leukemia is a type of cancer that begins in the lymphocytes, a kind of white blood cell found in the bone marrow. CLL generally progresses slowly, gradually leading to an overproduction of abnormal lymphocytes.

What is the significance of del17p in CLL?

Del17p refers to a deletion of a portion of the short arm of chromosome 17. This deletion is significant because it includes the TP53 gene, which is crucial for regulating cell division and preventing cancer. CLL patients with del17p often have a more aggressive disease course and may not respond well to standard chemotherapy.

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How is CLL Cytogenetics 1 performed?

A blood sample is drawn from the patient. In the lab, the chromosomes of lymphocytes are visualized using Karyotyping. FISH is then used to look specifically for the deletion of chromosome 17p.

Why is it important to test for chromosomal abnormalities in CLL?

Testing for chromosomal abnormalities helps in the risk stratification of CLL. It guides doctors in predicting the likely course of the disease and in making informed decisions regarding the most appropriate treatment strategies.

What information does the CLL Cytogenetics 1 test provide?

This test provides information about the presence or absence of the deletion in chromosome 17p. Having this deletion is associated with a more aggressive form of CLL and resistance to certain chemotherapy drugs.

Is there any specific preparation needed for the CLL Cytogenetics 1 test?

No specific preparation is needed for this test. However, it's important to inform your doctor of any medications you are currently taking.

What are the normal values for this test?

In a normal result, there is no deletion in chromosome 17p. The presence of del17p is considered abnormal and indicative of CLL.

Which doctor should I consult if my test results are abnormal?

If your test results are abnormal, it is important to consult a hematologist or oncologist specializing in the treatment of blood cancers like CLL.

How will the results of this test affect my treatment options?

The presence of del17p is associated with resistance to certain chemotherapy agents. This information can guide your doctor in choosing other, potentially more effective treatments such as targeted therapies or immunotherapies.

How often should this test be done?

This test is typically done at the time of CLL diagnosis to determine the disease’s genetic makeup. It may be repeated if there is a significant change in your disease or if you are considering a new treatment option.

Are there any modifiable factors that can affect the levels?

The del17p is a genetic abnormality and is not affected by lifestyle or environmental factors.

Can CLL be cured?

Currently, there is no cure for CLL. However, treatment can often control the disease for many years. Newer treatments are continually being developed, and some patients may achieve long-term remission.

Can the progression of CLL be prevented or slowed down?

While the progression of CLL cannot be prevented, it can sometimes be slowed down with proper treatment. Managing other health conditions, maintaining a healthy lifestyle, and following your doctor’s recommendations are also important.

Decoding the genetic abnormalities in CLL is fundamental in tailoring an effective treatment strategy. CLL Cytogenetics 1, which combines Karyotyping with FISH, provides crucial information about the presence of del17p. This knowledge, combined with the expertise of your doctor, is critical in managing CLL effectively. Regular follow-ups and adherence to the treatment plan laid out by your doctor are vital.

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