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BRAF V600E Mutation Analysis

The BRAF V600E mutation analysis is a highly specialized genetic test that detects the presence of the V600E mutation in the BRAF gene. This mutation results in an amino acid change at position 600 in BRAF, from valine (V) to glutamic acid (E). The BRAF gene is integral to the regulation of cell growth, and the V600E mutation can result in uncontrolled cell growth. This mutation is notably associated with different types of cancer, including melanoma, colorectal cancer, thyroid cancer, and others.

  • Test Name BRAF V600E Mutation Analysis
  • Sample Type Tissue
  • Preparations Required No specific preparation is required from the patient.
  • Report Time 7days

The importance of detecting the BRAF V600E mutation in cancer patients lies in the fact that this mutation has become a target for several cancer therapies. Identifying the presence of the V600E mutation can inform treatment decisions and indicate whether targeted therapy may be effective for a patient.

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Frequently Asked Questions

The BRAF V600E mutation is a specific change in the BRAF gene where the amino acid valine is replaced by glutamic acid at position 600. This mutation is known to promote cancer cell growth.

This analysis is important because the presence of the BRAF V600E mutation in cancer cells is associated with particular types of cancer and can impact the choice of treatment, particularly in the use of targeted therapies.

This test is typically performed on a blood sample or a sample of tissue from a tumor. DNA is extracted from the sample and analyzed for the presence of the V600E mutation in the BRAF gene.

This mutation is most commonly associated with melanoma. It is also found in a significant percentage of cases of thyroid cancer, colorectal cancer, and a few other types.

If you have the BRAF V600E mutation, your doctor may consider using targeted therapies that specifically target this mutation. This can often lead to more effective cancer treatment.

Targeted therapy is a type of cancer treatment that targets specific genes or proteins that contribute to cancer growth and development.

Yes, targeted therapies can have side effects, including fatigue, skin problems, and gastrointestinal issues. It's important to discuss these with your doctor.

The BRAF V600E mutation is usually not inherited but occurs during a person’s life. It is considered a somatic mutation, meaning it is acquired and occurs in certain cells, not in the entire body.

If the test is negative, it means that the BRAF V600E mutation is not present in the sampled cells. Your doctor will explore other treatment options that are more suitable for your type of cancer.

It's possible for mutations to occur over time, but the BRAF V600E mutation is usually present at the onset of certain types of cancer.

This test is generally performed on patients who have been diagnosed with cancer. If you have a family history of cancer, speak to your doctor about which tests are appropriate for you.

The BRAF V600E mutation analysis is highly reliable, but the accuracy can be influenced by the quality of the sample and the methodology used.

You should consult your doctor, who may refer you to an oncologist for further evaluation and discussion of treatment options.

No fasting is required for the BRAF V600E Mutation Analysis.

There are no significant risks associated with the blood draw. If a tissue sample is taken, there may be risks associated with the biopsy procedure.

The BRAF V600E Mutation Analysis is a crucial tool in modern oncology that helps in the customization of treatment plans. It can identify patients who might benefit from targeted therapies aimed at this specific genetic abnormality, often improving treatment efficacy. Understanding and acting upon the genetic aspects of cancer is increasingly becoming a central part of successful cancer treatment. It's important to be well-informed and proactive in discussing these testing and treatment options with your doctor.

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