BRAF Full Gene Mutation Analysis - Paraffin Block - Price, Normal Range | Sprint Diagnostics Hyderabad

Patient Preparing : No specific preparation required.

₹ 6000

BRAF Full Gene Mutation Analysis is a sophisticated genetic test that examines mutations in the BRAF gene from a tissue sample embedded in a paraffin block. The BRAF gene is a part of the MAP kinase signaling pathway, which regulates cell division and growth. Certain mutations in the BRAF gene can lead to uncontrolled cell growth and are often associated with various types of cancers, including melanoma, thyroid cancer, and colorectal cancer.

Utilizing tissue samples embedded in paraffin blocks is a common practice for preserving tissue specimens. These blocks are utilized for various histological and molecular analyses, including the investigation of genetic mutations. The analysis of the BRAF gene in a paraffin block can be particularly crucial in aiding the development of personalized treatment plans for patients with cancer.

Test Name BRAF Full Gene Mutation Analysis - Paraffin Block
Sample Type Paraffin-embedded tissue
Preparations Required No specific preparation required.
Report Time 7 days
Price in Hyderabad ₹ 6000

What is the purpose of BRAF Full Gene Mutation Analysis using Paraffin Blocks?

This test is used to detect mutations in the BRAF gene from tissue samples. It’s often used to identify cancer patients who might benefit from targeted therapies.

How is the tissue sample collected?

A tissue sample is collected, usually during a biopsy or surgery, and is then preserved in a paraffin block by healthcare professionals.

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What is the role of the BRAF gene in cancer?

The BRAF gene is involved in sending signals inside cells and in cell growth. Mutations in the BRAF gene can cause the protein it makes to be overactive, leading to uncontrolled cell growth and the development of cancer.

What are the benefits of using paraffin-embedded tissue for this analysis?

Paraffin-embedded tissues are well-preserved, allowing for better quality DNA extraction and testing, even from older samples.

What cancers are most commonly associated with BRAF mutations?

BRAF mutations are most commonly associated with melanoma but can also be found in colorectal, thyroid, and non-small cell lung cancers.

How can the results of this test impact treatment decisions?

The presence of BRAF mutations can make a patient eligible for targeted therapies specifically designed to inhibit the mutant BRAF protein, potentially leading to more effective treatments.

Are there any limitations to the analysis of paraffin-embedded tissues?

Yes, sometimes the fixation process of embedding tissues in paraffin can cause DNA degradation which can affect the quality of genetic material available for testing.

What is targeted therapy, and how does it work for patients with BRAF mutations?

Targeted therapy is a cancer treatment that targets specific molecules involved in the growth and spread of cancer cells. For patients with BRAF mutations, targeted therapies can specifically inhibit the mutant BRAF protein, which is involved in cancer cell growth.

Is there a possibility of a false-negative result?

Yes, if the sample quality is poor or if there is an issue with the DNA extraction process, it’s possible to receive a false-negative result.

What happens if the test results show no BRAF mutation?

If no BRAF mutation is detected, targeted therapy for BRAF might not be effective. Your doctor will consider other treatment options.

Can this test be used in monitoring cancer progression?

This test is primarily used for treatment planning. However, in some cases, it may be repeated to monitor the status of BRAF mutations during the course of the disease.

Are there any risks associated with this test?

The test itself has no associated risks. However, the biopsy procedure used to obtain the tissue sample carries some risks, including infection and bleeding.

Are BRAF mutations hereditary?

Most BRAF mutations are not hereditary and occur during a person’s lifetime. They are often a result of environmental factors such as UV exposure.

What kind of doctor should I consult if I test positive for a BRAF mutation?

You should consult your doctor who may refer you to an oncologist specializing in the type of cancer associated with the BRAF mutation.

How reliable is this test?

The reliability of this test is generally high, but it can be influenced by the quality of the tissue sample and the techniques used in the analysis.

Understanding the genetic makeup of cancer through tests like the BRAF Full Gene Mutation Analysis is a cornerstone in modern oncology. It is essential in crafting targeted treatment plans aimed at the specific genetic abnormalities in individual cancers. If you or a loved one have been diagnosed with cancer, it's important to explore all avenues for the best possible treatment, and understanding the genetic aspects of the disease is often a critical component of this process.

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