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Biochemical Analysis - Synovial Fluid

Synovial fluid is a viscous liquid found in the cavities of synovial joints. It reduces friction between the articular cartilage and other tissues in joints by lubricating and cushioning them during movement. Biochemical analysis of synovial fluid, specifically looking at glucose, protein, and chloride levels, can be very informative in the diagnosis and management of various joint disorders.


  • Test Name Biochemical Analysis - Synovial Fluid
  • Sample Type Synovial Fluid
  • Preparations Required No specific preparation is needed for this test. However, it’s important to inform the doctor of any medications being taken, as they may influence the test results.
  • Report Time 4 hours

In certain conditions, such as arthritis, there can be an abnormal buildup or changes in the composition of the synovial fluid. By analyzing the levels of glucose, protein, and chloride in the synovial fluid, healthcare professionals can obtain vital information regarding the health of the joints and the presence of certain conditions.

Home Sample Collection Process
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Sample Collection by Phlebotomist
Sample Collection by Phlebotomist
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Reporting of the sample at lab
Reporting of the sample at lab
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Frequently Asked Questions

The biochemical analysis of synovial fluid is important because it helps in diagnosing various joint disorders such as arthritis, gout, and infections in the joint. Abnormal levels of glucose, protein, or chloride can indicate an underlying disease affecting the joint.

Synovial fluid is obtained through a procedure called arthrocentesis or joint aspiration. This involves using a sterile needle to withdraw fluid from the joint space.

In normal synovial fluid, the glucose levels are usually similar to blood glucose levels. Lower glucose levels in synovial fluid compared to blood might indicate an inflammatory or infectious process.

Increased protein levels in synovial fluid can be indicative of inflammatory conditions such as rheumatoid arthritis. In non-inflammatory conditions like osteoarthritis, protein levels are generally not as elevated.

Chloride levels in synovial fluid are typically higher than in serum. Low chloride levels might suggest an inflammatory process.

The risks of joint aspiration include infection, bleeding, and discomfort at the site where the needle was inserted.

Yes, medication such as anti-inflammatory drugs or antibiotics can affect the results of this test. It is important to inform the doctor of any medication you are taking.

No specific preparation is usually required for joint aspiration, but follow any instructions provided by your doctor.

During the procedure, you will be asked to either sit or lie down in a position that allows the doctor to easily access the joint. A local anesthetic may be used to numb the area, and a needle will be inserted into the joint space to withdraw fluid.

Besides biochemical analysis, other tests such as cell count, crystal analysis, and microbial culture might also be performed on synovial fluid.

If the test results are abnormal, it is advisable to consult a rheumatologist or orthopedic doctor for further evaluation and management.

The results of the biochemical analysis of synovial fluid will help your doctor to diagnose the underlying condition affecting your joints. This will guide them in recommending the appropriate treatment.

Modifiable factors include medications, diet, exercise, and weight. Managing these factors can influence the health of your joints.

Non-modifiable factors include age, gender, and genetic predisposition.

This test can be done on any synovial joint, but it is most commonly performed on the knee. Other joints that may be tested include the hip, shoulder, elbow, wrist, and ankle.

Synovial fluid composition can be crucial in the diagnosis and management of joint-related diseases. It’s important to discuss the results and any concerns with your doctor who can provide the necessary context and guide you on the next steps. Following your doctor’s advice and adhering to any recommended treatment can be vital for managing conditions that affect the synovial fluid and maintaining joint health.

BIOCHEMICAL ANALYSIS, SYNOVIAL FLUID
₹ 570
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