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B-Cell Gene Rearrangement (IGH Clonality)

B-Cell Gene Rearrangement (IGH Clonality)

The B-cell Gene Rearrangement test, also known as Immunoglobulin Heavy chain (IGH) Clonality test, is a specialized genetic test used primarily in the diagnosis of diseases related to B-cells, especially B-cell malignancies like lymphomas and leukemias.

  • Test Name B-Cell Gene Rearrangement (IGH Clonality)
  • Sample Type Blood or bone marrow
  • Preparations Required No specific preparation or restrictions are required before this test.
  • Report Time 17 days

Our immune system consists of various types of cells, each playing a specific role. B-cells, a type of white blood cell, are responsible for producing antibodies against pathogens. In order to respond to a vast range of pathogens, B-cells undergo a process called V(D)J recombination to produce a diverse array of antibody molecules. However, when this process goes awry, it can lead to the development of B-cell malignancies. The IGH Clonality test is designed to detect these abnormal rearrangements, aiding in disease diagnosis and treatment.

The B-cell Gene Rearrangement test uses a technique called Polymerase Chain Reaction (PCR) to detect abnormal gene rearrangements in the Immunoglobulin Heavy chain (IGH) region of B-cells. These abnormal rearrangements, known as clonal rearrangements, are hallmark features of B-cell malignancies.

The IGH Clonality test has high diagnostic utility as it can differentiate between a benign (reactive) proliferation of B-cells and a malignant (clonal) proliferation. This test is particularly useful in cases where traditional diagnostic methods, like histopathology, are inconclusive.

Furthermore, the test has prognostic implications as well. The presence of certain gene rearrangements can inform the course of the disease and guide treatment decisions. For instance, certain rearrangements are associated with a more aggressive disease course.

Home Sample Collection Process

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Sample Collection by Phlebotomist
Sample Collection by Phlebotomist
Reporting of the sample at lab
Reporting of the sample at lab
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Frequently Asked Questions

The test is typically ordered when a patient presents with symptoms suggestive of a B-cell malignancy (like unexplained weight loss, fever, night sweats, swollen lymph nodes) and when initial diagnostic tests, such as blood tests and imaging studies, suggest the possibility of a B-cell malignancy.

A positive result indicates the presence of a clonal IGH gene rearrangement, suggesting a B-cell malignancy like lymphoma or leukemia. However, the result should always be interpreted in conjunction with clinical findings and other diagnostic tests.

The sample required for this test is either blood or tissue, depending on the type of suspected B-cell malignancy. For example, in suspected lymphoma cases, a biopsy of the swollen lymph node may be taken. For leukemia, a blood sample or bone marrow biopsy may be required.

No special precautions are required before the test. However, always inform your doctor about any medications or supplements you are taking as they might interfere with the test results.

This test is not meant for regular screening. It is performed when there is a strong clinical suspicion of a B-cell malignancy, based on symptoms and other diagnostic tests.

If the test results are abnormal, you should consult a hematologist or an oncologist for further guidance and treatment.

Treatment for B-cell malignancies depends on the type and stage of the disease and can include chemotherapy, targeted therapy, radiation therapy, immunotherapy, or stem cell transplant.

Most B-cell malignancies cannot be prevented as they result from genetic changes that occur spontaneously. However, leading a healthy lifestyle and getting regular check-ups can help in early detection and treatment.

Technical issues like sample quality and handling can affect the test results. Also, the test may not detect low levels of clonality or rare gene rearrangements.

No, the sample collection for this test requires professional medical supervision and should be conducted in a healthcare setting.

The B-Cell Gene Rearrangement (IGH Clonality) test is a valuable tool in the diagnosis and management of B-cell malignancies. By identifying abnormal gene rearrangements, it aids in the determination of appropriate treatment strategies, ultimately leading to better patient outcomes. Always consult your doctor for any health concerns and follow their guidance on diagnostic testing.

B-Cell Gene Rearrangement (IGH Clonality)
₹ 19000
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Locations Near You in Hyderabad
  • 4KM from Madhapur
  • 3KM from Banjara Hills
  • 1.9KM from Yusufguda
  • 3KM from Madhura Nagar
  • 5KM from Shaikpet