Anti-Skeletal (Striated) Muscle Antibody (ASKA) - IFA with Reflex Titres

The ASKA test is important because it helps to diagnose and monitor autoimmune diseases that affect the skeletal muscles, such as myasthenia gravis. It is especially valuable for identifying cases where thymoma (a tumor of the thymus gland) is present, which is often associated with high levels of these antibodies.

The ASKA test is performed using a blood sample. The blood is sent to a laboratory where the levels of anti-skeletal muscle antibodies are measured using immunofluorescence assay (IFA) with reflex titres.

A positive ASKA result indicates the presence of antibodies against skeletal muscles. This can be associated with autoimmune disorders like myasthenia gravis, and can also indicate the presence of thymoma.

Reflex titres in the ASKA test refer to further testing to quantify the levels of antibodies if the initial screening test is positive. This helps in assessing the severity and activity of the disease.

No, fasting is not required for the ASKA test.

Symptoms that might lead a doctor to order an ASKA test include muscle weakness, fatigue, difficulty in swallowing, double vision, and drooping eyelids. These symptoms are often seen in myasthenia gravis.

Yes, some medications can affect the immune system and might alter the levels of antibodies in the blood. It’s important to tell your doctor about any medications you are taking.

ASKA specifically tests for antibodies against skeletal muscles, while other muscle antibody tests might test for antibodies against different components of the muscles or other tissues associated with muscles.

The ASKA test can be used to diagnose myasthenia gravis, monitor the disease progression, and assess the response to treatment. It can also help in identifying thymoma, which is common in myasthenia gravis patients.

No, the ASKA test is usually used in conjunction with clinical evaluation and other laboratory tests for the diagnosis of autoimmune disorders affecting skeletal muscles.

After receiving your ASKA test results, your doctor will discuss them with you and may recommend further tests or treatment based on the findings.

The normal range for ASKA titres can vary depending on the laboratory. Generally, no antibodies or very low levels are considered normal.

The risks associated with the ASKA test are minimal and are mainly related to the blood draw, such as slight pain or bruising at the needle site.

Certain medications, infections, or other autoimmune conditions might cause a false positive or false negative ASKA test result.

In case of an abnormal ASKA value, it is recommended to consult a rheumatologist or a neurologist specializing in neuromuscular disorders.

The Anti-Skeletal (Striated) Muscle Antibody (ASKA) test is a vital tool in the diagnosis and management of autoimmune disorders affecting skeletal muscles. Understanding the implications of the results can help in making informed decisions regarding treatment and management of these conditions. Always discuss your results and concerns with your doctor to ensure that you receive the appropriate care and support.