Anti-Phospholipase A2 Receptor (PLA2R) IgG Test - Price, Normal Range | Sprint Diagnostics Hyderabad

Patient Preparing : No special preparation is needed for this test.

₹ 5000


The Anti-Phospholipase A2 Receptor (PLA2R) IgG test is a blood test that detects the presence of antibodies against the Phospholipase A2 Receptor (PLA2R). This receptor is predominantly found in the kidneys, particularly in the podocytes which are critical cells involved in the filtration of blood. Anti-PLA2R antibodies are significantly associated with a kidney disease known as primary membranous nephropathy (MN), which is an autoimmune disease characterized by the thickening of a part of the kidney's filtration units, known as glomeruli.

Primary membranous nephropathy is one of the common causes of nephrotic syndrome in adults. Nephrotic syndrome is characterized by proteinuria (high levels of protein in urine), low levels of albumin in the blood, and swelling in the legs and other areas of the body.

Test Name ANTI PHOSPHOLIPASE A2 RECEPTOR (PLA2R) IgG, IFA
Sample Type Blood
Preparations Required No special preparation is needed for this test.
Report Time 2 days
Price in Hyderabad ₹ 5000

What is the Anti-Phospholipase A2 Receptor (PLA2R) IgG test?

The Anti-PLA2R IgG test is a blood test used to detect antibodies against the Phospholipase A2 Receptor. It is particularly used in diagnosing primary membranous nephropathy, an autoimmune kidney disease.

Why is the Anti-PLA2R IgG test important?

This test is important because it can help diagnose primary membranous nephropathy. Identifying the cause of nephrotic syndrome or kidney disease is crucial for appropriate treatment and management.

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What are the symptoms of primary membranous nephropathy?

Symptoms include swelling in the legs and sometimes around the eyes, foamy urine due to excessive protein, fatigue, and unintentional weight loss. In some cases, it may not cause symptoms in the early stages.

How is primary membranous nephropathy treated?

Treatment can include medications to reduce the immune system's activity, blood pressure medications to protect the kidneys, and diuretics to reduce swelling. The treatment plan depends on the severity and progression of the disease.

What does a positive result mean?

A positive result for Anti-PLA2R IgG antibodies suggests a diagnosis of primary membranous nephropathy. However, the test result should be interpreted in conjunction with other clinical information and laboratory tests.

Can primary membranous nephropathy lead to complications?

Yes, if left untreated, primary membranous nephropathy can lead to chronic kidney disease, kidney failure, and an increased risk of blood clots.

Are there any modifiable factors that can affect Anti-PLA2R levels?

Medications affecting the immune response may alter Anti-PLA2R levels. Additionally, lifestyle changes aimed at supporting kidney health and immune system balance might have an impact.

Are there any non-modifiable factors that can affect Anti-PLA2R levels?

Genetic predisposition and certain autoimmune or viral conditions might contribute to the development of Anti-PLA2R antibodies.

What other tests might be done along with the Anti-PLA2R IgG test?

Other tests might include urinalysis, blood tests for kidney function (creatinine, blood urea nitrogen), and in some cases, a kidney biopsy.

When should one get tested for Anti-PLA2R IgG?

Testing for Anti-PLA2R IgG should be done if an individual has signs of nephrotic syndrome or has been diagnosed with membranous nephropathy to confirm if it is primary or secondary in nature.

Is primary membranous nephropathy the same as secondary membranous nephropathy?

No,primary membranous nephropathy is an autoimmune disease, while secondary membranous nephropathy is due to other underlying causes such as medications, infections, or other autoimmune diseases.

What are the normal values for the Anti-PLA2R IgG test?

Normal values may vary between laboratories, but generally, the absence or low levels of Anti-PLA2R IgG antibodies is considered normal.

How often should one be tested?

The frequency of testing depends on the clinical situation and should be determined by the doctor overseeing the patient’s care.

Which doctor should be consulted in case of abnormal Anti-PLA2R IgG levels?

In case of abnormal Anti-PLA2R IgG levels, consultation with a nephrologist is advised.

Can primary membranous nephropathy be cured?

There is no cure for primary membranous nephropathy, but treatments can help manage symptoms and slow the progression of kidney damage.

For individuals who have been diagnosed with membranous nephropathy or exhibit symptoms indicative of kidney disease, the Anti-PLA2R IgG test can be an important diagnostic tool. A positive test can confirm the diagnosis of primary membranous nephropathy and help guide management and treatment decisions. Managing this condition effectively requires regular monitoring and collaboration with a nephrologist to tailor the treatment to the individual patient’s needs.

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