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Anti-Aquaporin-4 / NMO Antibodies

The Anti-Aquaporin-4 / NMO Antibodies test in Cerebrospinal Fluid (CSF) is an essential diagnostic tool for Neuromyelitis Optica, also known as Devic's disease. Neuromyelitis Optica (NMO) is an autoimmune disorder characterized by the immune system attacking and damaging the central nervous system, specifically the optic nerves and spinal cord. Anti-Aquaporin-4 antibodies are autoantibodies that target a protein called aquaporin-4, found on the surface of cells in the brain and spinal cord. While these antibodies are usually tested in the blood, testing them in the CSF can provide additional information about the presence and activity of the disease in the central nervous system.


  • Test NameAnti-Aquaporin-4 / NMO Antibodies (Neuromyelitis Optica Antibodies) in Cerebrospinal Fluid (CSF) Test
  • Sample TypeCerebrospinal Fluid (CSF)
  • Preparations RequiredNo specific preparation is required for this test.
  • Report Time6 hours

Home Sample Collection Process

1
Book your convenient slot
Book your convenient slot
2
Sample Collection by Phlebotomist
Sample Collection by Phlebotomist
3
Reporting of the sample at lab
Reporting of the sample at lab
4
Download Reports
Download Reports
Frequently Asked Questions

This test detects the presence of antibodies against the aquaporin-4 protein in the cerebrospinal fluid, which is the fluid surrounding the brain and spinal cord. The presence of these antibodies in the CSF is associated with Neuromyelitis Optica.

The CSF sample is collected through a lumbar puncture (spinal tap) procedure, where a needle is inserted into the lower back to collect a small amount of cerebrospinal fluid.

Testing for Anti-Aquaporin-4 antibodies in CSF can provide additional insight into the involvement of the central nervous system in Neuromyelitis Optica. It may help in confirming the diagnosis and guiding the treatment strategy, especially in complicated cases.

Common symptoms include eye pain, vision loss, weakness in the limbs, impaired coordination, and bladder and bowel dysfunction.

A positive result indicates the presence of Anti-Aquaporin-4 antibodies in the CSF, which is strongly suggestive of Neuromyelitis Optica. This information, combined with clinical symptoms and other tests, can be used to confirm a diagnosis.

Currently, there is no cure for NMO. However, treatments are available to manage symptoms and reduce the frequency of relapses.

Yes, some individuals with NMO do not have detectable levels of Anti-Aquaporin-4 antibodies. This form of the disease is sometimes called seronegative NMO.

You should consult a neurologist, as Neuromyelitis Optica is a neurological disorder.

Lumbar puncture is generally safe, but there can be risks such as headache, infection, or bleeding at the puncture site. Your doctor will discuss these risks with you.

NMO and MS are both autoimmune disorders affecting the central nervous system, but they are distinct conditions. NMO primarily affects the optic nerves and spinal cord, whereas MS can affect any part of the central nervous system.

Immunosuppressive medications may influence the levels of Anti-Aquaporin-4 antibodies. Inform your doctor of any medications you are taking.

There is no clear evidence that NMO is hereditary, but some individuals with the condition have family members with other autoimmune diseases.

Treatment usually involves medications to suppress the immune system and manage symptoms. This may include corticosteroids, immunosuppressive drugs, and plasma exchange.

Regular follow-ups with a neurologist, adhering to medication regimens, physiotherapy, and a support system can help manage symptoms and improve quality of life.

The impact of Neuromyelitis Optica on a person's life varies. With proper treatment and management, many individuals can lead productive lives, although some may experience disability due to symptoms.

It's important to understand that the detection of Anti-Aquaporin-4 / NMO antibodies in the CSF can be a vital tool in diagnosing and managing Neuromyelitis Optica. This condition requires a comprehensive approach for diagnosis and treatment. If you or a loved one are experiencing symptoms or have been diagnosed with NMO, it is essential to have a thorough discussion with your doctor to understand the condition and the options available for management and care.

Anti-Aquaporin-4 / NMO Antibodies ( Neuromyelitis Optica Antibodies)-CSF
₹ 4500
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Locations Near You in Hyderabad
  • 4KM from Madhapur
  • 3KM from Banjara Hills
  • 1.9KM from Yusufguda
  • 3KM from Madhura Nagar
  • 5KM from Shaikpet