Anti-Aquaporin-4-NMO Antibodies Cerebrospinal Fluid Test | Sprint Diagnostics Hyderabad

Patient Preparing : No specific preparation is required for this test.

₹ 9000


The Anti-Aquaporin-4 / NMO Antibodies test in Cerebrospinal Fluid (CSF) is an essential diagnostic tool for Neuromyelitis Optica, also known as Devic's disease. Neuromyelitis Optica (NMO) is an autoimmune disorder characterized by the immune system attacking and damaging the central nervous system, specifically the optic nerves and spinal cord. Anti-Aquaporin-4 antibodies are autoantibodies that target a protein called aquaporin-4, found on the surface of cells in the brain and spinal cord. While these antibodies are usually tested in the blood, testing them in the CSF can provide additional information about the presence and activity of the disease in the central nervous system.

Test Name Anti-Aquaporin-4 / NMO Antibodies (Neuromyelitis Optica Antibodies) in Cerebrospinal Fluid (CSF) Test
Sample Type Cerebrospinal Fluid (CSF)
Preparations Required No specific preparation is required for this test.
Report Time 6 hours
Price in Hyderabad ₹ 9000

What is the Anti-Aquaporin-4 / NMO Antibodies test in CSF?

This test detects the presence of antibodies against the aquaporin-4 protein in the cerebrospinal fluid, which is the fluid surrounding the brain and spinal cord. The presence of these antibodies in the CSF is associated with Neuromyelitis Optica.

How is the CSF sample collected?

The CSF sample is collected through a lumbar puncture (spinal tap) procedure, where a needle is inserted into the lower back to collect a small amount of cerebrospinal fluid.

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Why is testing for these antibodies in CSF important?

Testing for Anti-Aquaporin-4 antibodies in CSF can provide additional insight into the involvement of the central nervous system in Neuromyelitis Optica. It may help in confirming the diagnosis and guiding the treatment strategy, especially in complicated cases.

What are the symptoms of Neuromyelitis Optica?

Common symptoms include eye pain, vision loss, weakness in the limbs, impaired coordination, and bladder and bowel dysfunction.

What does a positive result mean?

A positive result indicates the presence of Anti-Aquaporin-4 antibodies in the CSF, which is strongly suggestive of Neuromyelitis Optica. This information, combined with clinical symptoms and other tests, can be used to confirm a diagnosis.

Is there a cure for Neuromyelitis Optica?

Currently, there is no cure for NMO. However, treatments are available to manage symptoms and reduce the frequency of relapses.

Can NMO occur without Anti-Aquaporin-4 antibodies?

Yes, some individuals with NMO do not have detectable levels of Anti-Aquaporin-4 antibodies. This form of the disease is sometimes called seronegative NMO.

What kind of doctor should I consult if I have abnormal Anti-Aquaporin-4 / NMO antibodies in CSF?

You should consult a neurologist, as Neuromyelitis Optica is a neurological disorder.

Are there any risks associated with the lumbar puncture procedure?

Lumbar puncture is generally safe, but there can be risks such as headache, infection, or bleeding at the puncture site. Your doctor will discuss these risks with you.

How are Neuromyelitis Optica and Multiple Sclerosis (MS) different?

NMO and MS are both autoimmune disorders affecting the central nervous system, but they are distinct conditions. NMO primarily affects the optic nerves and spinal cord, whereas MS can affect any part of the central nervous system.

Is there any medication that can influence the test results?

Immunosuppressive medications may influence the levels of Anti-Aquaporin-4 antibodies. Inform your doctor of any medications you are taking.

Is Neuromyelitis Optica hereditary?

There is no clear evidence that NMO is hereditary, but some individuals with the condition have family members with other autoimmune diseases.

What is the treatment for Neuromyelitis Optica?

Treatment usually involves medications to suppress the immune system and manage symptoms. This may include corticosteroids, immunosuppressive drugs, and plasma exchange.

How can I manage symptoms and improve my quality of life if diagnosed with NMO?

Regular follow-ups with a neurologist, adhering to medication regimens, physiotherapy, and a support system can help manage symptoms and improve quality of life.

Can I lead a normal life with Neuromyelitis Optica?

The impact of Neuromyelitis Optica on a person's life varies. With proper treatment and management, many individuals can lead productive lives, although some may experience disability due to symptoms.

It's important to understand that the detection of Anti-Aquaporin-4 / NMO antibodies in the CSF can be a vital tool in diagnosing and managing Neuromyelitis Optica. This condition requires a comprehensive approach for diagnosis and treatment. If you or a loved one are experiencing symptoms or have been diagnosed with NMO, it is essential to have a thorough discussion with your doctor to understand the condition and the options available for management and care.

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