AML Genetics Prognostication Test, Price, Normal Range | Sprint Diagnostics Hyderabad

Patient Preparing : No specific preparation is needed for this test. Fasting is not required, and no restrictions are placed on water consumption. It is advised to follow any additional instructions provided by the healthcare professional.

₹ 26500

Acute Myeloid Leukemia (AML) is a type of cancer that affects the blood and bone marrow, characterized by the rapid growth of abnormal white blood cells. AML Genetics Prognostication is an advanced diagnostic panel that involves Karyotyping, Fluorescence In Situ Hybridization (FISH) analysis for three markers, and testing for mutations in the FLT3, NPM1, and CEBPA genes. This prognostic panel plays a crucial role in the evaluation of AML and helps in devising personalized treatment strategies.

Karyotyping involves the analysis of chromosomes in blood or bone marrow cells. This helps in identifying chromosomal abnormalities that may be involved in the development of AML. FISH is a technique used to detect specific DNA sequences on chromosomes, and in this context, it is used to find changes that are common in AML. The FLT3, NPM1, and CEBPA genes have been identified as having particular importance in AML. Mutations in these genes are associated with prognosis and can affect treatment decisions.

Test Name AML Genetics Prognostication (Karyotyping + FISH 3 markers + FLT3 + NPM1 + CEBPA)
Sample Type Blood or Bone Marrow
Preparations Required No specific preparation is needed for this test. Fasting is not required, and no restrictions are placed on water consumption. It is advised to follow any additional instructions provided by the healthcare professional.
Report Time 12 days
Price in Hyderabad ₹ 26500

Why is genetic testing important in AML?

Genetic testing in AML is important as it helps in determining the prognosis and selecting an appropriate treatment plan. Certain genetic changes are associated with a better or worse response to standard therapies and may influence decisions regarding bone marrow transplantation.

What is Karyotyping?

Karyotyping is a test that evaluates the number and structure of an individual’s chromosomes. In AML, this test can reveal chromosomal abnormalities that are often associated with the disease.

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What does FISH analysis involve?

FISH (Fluorescence In Situ Hybridization) involves using fluorescent probes to bind to specific DNA sequences on chromosomes. It’s used to visualize and map the genetic material in an individual's cells, including blood or bone marrow.

What do FLT3, NPM1, and CEBPA tests reveal?

FLT3, NPM1, and CEBPA tests look for mutations in these specific genes. Mutations in FLT3 are often associated with a poor prognosis in AML, while mutations in NPM1 and CEBPA can be associated with a more favorable prognosis.

How is the sample collected for AML Genetic Prognostication?

The sample is typically collected from blood or bone marrow. Bone marrow aspiration might be performed to collect a sample from the pelvic bone or the breastbone.

Is there any risk associated with bone marrow aspiration?

Bone marrow aspiration is a procedure that carries some risks and discomfort. These might include pain, infection, bleeding, and bruising at the aspiration site.

How do the results of AML Genetic Prognostication influence treatment?

The results of AML Genetic Prognostication can influence treatment choices including the use of chemotherapy, bone marrow transplantation, and enrollment in clinical trials.

Can this test be used for monitoring AML?

Yes, this test can be used to monitor the progression of AML and to evaluate the effectiveness of treatment, especially if a specific chromosomal abnormality or gene mutation is known.

Is AML Genetic Prognostication a one-time test?

Usually, it is performed at diagnosis for prognostic purposes but can also be repeated to monitor the disease or if a relapse occurs.

Can genetic testing predict the development of AML in individuals with no symptoms?

AML Genetic Prognostication is not typically used as a screening test in the general population but may be used in individuals with a known family history or other risk factors for AML.

Which doctor should I consult if the test shows an abnormal result?

If the test shows abnormal results, it is important to consult an oncologist who specializes in the treatment of blood cancers.

Are there any factors that can affect the results of this test?

Yes, factors such as recent blood transfusions or chemotherapy can affect the results of this test.

How reliable are the results of AML Genetic Prognostication?

The reliability of the results depends on the quality of the sample and the precision of the laboratory analysis. It is considered a highly reliable set of tests when performed in an accredited laboratory.

Can this test detect all genetic changes associated with AML?

No, this test includes specific genetic tests and analyses that are known to be significant in AML prognosis, but there are other less common genetic changes that this test might not detect.

Is this test covered by insurance?

Coverage for this test depends on the insurance company and the healthcare plan. It’s advised to check with the insurance provider for specifics regarding coverage.

AML Genetics Prognostication is vital in understanding the complexity of Acute Myeloid Leukemia. By assessing the genetic abnormalities and mutations, doctors can make more informed decisions regarding treatment strategies. It is essential for patients to communicate with their doctors and understand the importance of these tests in managing and treating AML. Patients should also consider discussing the financial aspects and insurance coverage for these tests.

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