Autoimmune Lymphoproliferative Syndrome Test Price, Normal Range | Sprint Diagnostics Hyderabad

Patient Preparing : No special preparation is needed for this test. Continue with your normal diet and medications unless otherwise directed by your doctor.

₹ 5000


Autoimmune Lymphoproliferative Syndrome (ALPS) is a rare genetic disorder that affects the immune system, causing it to attack the body's own tissues and organs (autoimmunity). ALPS is characterized by an overproduction of white blood cells, leading to enlarged lymph nodes and spleen (lymphoproliferation). Double Negative T Cells (DNTs) are a specific type of white blood cell that is unusually abundant in individuals with ALPS. Screening for ALPS by analyzing DNTs levels is crucial for early diagnosis, management, and understanding the course of this disorder.

ALPS primarily affects children, though symptoms may not be present until later in life. Symptoms include chronic enlargement of lymph nodes, fatigue, frequent infections, and an increased risk of autoimmune disorders and lymphoma. DNT analysis helps to distinguish ALPS from other immune system disorders with similar symptoms.

Test Name ALPS (Autoimmune Lymphoproliferative Syndrome) Screening/Double Negative T Cell Analysis
Sample Type Blood Sample
Preparations Required No special preparation is needed for this test. Continue with your normal diet and medications unless otherwise directed by your doctor.
Report Time 2 days
Price in Hyderabad ₹ 5000

What is ALPS Screening/Double Negative T Cell analysis?

ALPS Screening, including Double Negative T Cell analysis, is a diagnostic test that measures the levels of Double Negative T Cells in the blood. An increased level of DNTs is a hallmark of ALPS.

Why is it important to screen for ALPS?

Screening for ALPS is essential to identify the disorder early, monitor its progression, and manage symptoms. Timely intervention can prevent complications such as organ damage and lower the risk of developing lymphoma.

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What are Double Negative T Cells?

Double Negative T Cells are a type of white blood cell that lacks two specific markers typically found on the surface of T cells. An increased level of DNTs is characteristic of ALPS and helps in its diagnosis.

Who should undergo ALPS Screening?

Individuals with chronic enlarged lymph nodes, history of autoimmune diseases, recurrent infections, family history of ALPS, or other symptoms suggestive of immune system dysfunction should consider undergoing ALPS screening.

How is the test performed?

A healthcare professional will draw a blood sample from your arm. The sample is sent to a laboratory, where specialized techniques are used to analyze the levels of Double Negative T Cells.

What does a high level of Double Negative T Cells indicate?

A high level of DNTs suggests a possible diagnosis of ALPS, but further tests and clinical assessment are needed for a definitive diagnosis.

What are the symptoms of ALPS?

Common symptoms of ALPS include chronic enlargement of the lymph nodes, fatigue, frequent infections, anemia, and an increased risk of autoimmune disorders and lymphoma.

What treatment options are available for ALPS?

There is no cure for ALPS, but treatment aims to manage symptoms and prevent complications. Treatment options include immunosuppressive medications, steroids, and in some cases, biological therapies or splenectomy.

Can ALPS be cured?

ALPS cannot be cured, but with proper management, many individuals with ALPS can lead normal lives. It is essential to work closely with a doctor specialized in immunology for the management of ALPS.

Is ALPS a genetic disorder?

Yes, ALPS is a genetic disorder, typically inherited in an autosomal dominant pattern. However, cases without a known family history can occur.

Are there lifestyle modifications that can help manage ALPS?

Maintaining a healthy lifestyle, including a balanced diet, regular exercise, and avoiding smoking and excessive alcohol consumption can help manage symptoms and improve quality of life for individuals with ALPS.

How can I prepare for the test?

No special preparation is needed for the ALPS screening test. You can eat and drink normally and take your medications unless otherwise instructed by your doctor.

Is ALPS a common condition?

No, ALPS is a rare disorder. However, it's essential to diagnose and manage it effectively to prevent complications.

Which doctor should I consult if the test shows high levels of Double Negative T Cells?

If the test shows high levels of Double Negative T Cells, you should consult a doctor specializing in immunology or hematology for further evaluation and management.

Can ALPS be prevented?

Since ALPS is a genetic disorder, it cannot be prevented. However, early diagnosis and management can prevent or delay the onset of complications.

ALPS is a lifelong process that requires careful monitoring and management. It is crucial to work in close collaboration with healthcare professionals specializing in immunology and hematology to ensure optimal management of this disorder. Regular check-ups, following the treatment plan, and adopting a healthy lifestyle can significantly improve the quality of life for individuals with ALPS.

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