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ALPS Screening/Double Negative T Cell Analysis

Autoimmune Lymphoproliferative Syndrome (ALPS) is a rare genetic disorder that affects the immune system, causing it to attack the body's own tissues and organs (autoimmunity). ALPS is characterized by an overproduction of white blood cells, leading to enlarged lymph nodes and spleen (lymphoproliferation). Double Negative T Cells (DNTs) are a specific type of white blood cell that is unusually abundant in individuals with ALPS. Screening for ALPS by analyzing DNTs levels is crucial for early diagnosis, management, and understanding the course of this disorder.


  • Test NameALPS (Autoimmune Lymphoproliferative Syndrome) Screening/Double Negative T Cell Analysis
  • Sample TypeBlood Sample
  • Preparations RequiredNo special preparation is needed for this test. Continue with your normal diet and medications unless otherwise directed by your doctor.
  • Report Time2 days

ALPS primarily affects children, though symptoms may not be present until later in life. Symptoms include chronic enlargement of lymph nodes, fatigue, frequent infections, and an increased risk of autoimmune disorders and lymphoma. DNT analysis helps to distinguish ALPS from other immune system disorders with similar symptoms.

Home Sample Collection Process

1
Book your convenient slot
Book your convenient slot
2
Sample Collection by Phlebotomist
Sample Collection by Phlebotomist
3
Reporting of the sample at lab
Reporting of the sample at lab
4
Download Reports
Download Reports
Frequently Asked Questions

ALPS Screening, including Double Negative T Cell analysis, is a diagnostic test that measures the levels of Double Negative T Cells in the blood. An increased level of DNTs is a hallmark of ALPS.

Screening for ALPS is essential to identify the disorder early, monitor its progression, and manage symptoms. Timely intervention can prevent complications such as organ damage and lower the risk of developing lymphoma.

Double Negative T Cells are a type of white blood cell that lacks two specific markers typically found on the surface of T cells. An increased level of DNTs is characteristic of ALPS and helps in its diagnosis.

Individuals with chronic enlarged lymph nodes, history of autoimmune diseases, recurrent infections, family history of ALPS, or other symptoms suggestive of immune system dysfunction should consider undergoing ALPS screening.

A healthcare professional will draw a blood sample from your arm. The sample is sent to a laboratory, where specialized techniques are used to analyze the levels of Double Negative T Cells.

A high level of DNTs suggests a possible diagnosis of ALPS, but further tests and clinical assessment are needed for a definitive diagnosis.

Common symptoms of ALPS include chronic enlargement of the lymph nodes, fatigue, frequent infections, anemia, and an increased risk of autoimmune disorders and lymphoma.

There is no cure for ALPS, but treatment aims to manage symptoms and prevent complications. Treatment options include immunosuppressive medications, steroids, and in some cases, biological therapies or splenectomy.

ALPS cannot be cured, but with proper management, many individuals with ALPS can lead normal lives. It is essential to work closely with a doctor specialized in immunology for the management of ALPS.

Yes, ALPS is a genetic disorder, typically inherited in an autosomal dominant pattern. However, cases without a known family history can occur.

Maintaining a healthy lifestyle, including a balanced diet, regular exercise, and avoiding smoking and excessive alcohol consumption can help manage symptoms and improve quality of life for individuals with ALPS.

No special preparation is needed for the ALPS screening test. You can eat and drink normally and take your medications unless otherwise instructed by your doctor.

No, ALPS is a rare disorder. However, it's essential to diagnose and manage it effectively to prevent complications.

If the test shows high levels of Double Negative T Cells, you should consult a doctor specializing in immunology or hematology for further evaluation and management.

Since ALPS is a genetic disorder, it cannot be prevented. However, early diagnosis and management can prevent or delay the onset of complications.

ALPS is a lifelong process that requires careful monitoring and management. It is crucial to work in close collaboration with healthcare professionals specializing in immunology and hematology to ensure optimal management of this disorder. Regular check-ups, following the treatment plan, and adopting a healthy lifestyle can significantly improve the quality of life for individuals with ALPS.

ALPS (Auto immune Lymphoproliferative syndrome) Screening /Double Negative T Cell analysis
₹ 5000 Book Test
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Locations Near You in Hyderabad
  • 4KM from Madhapur
  • 3KM from Banjara Hills
  • 1.9KM from Yusufguda
  • 3KM from Madhura Nagar
  • 5KM from Shaikpet