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Lab Test

ALK/EML4-FISH (Paraffin Block)

ALK/EML4-FISH is a molecular diagnostic test using the Fluorescence In Situ Hybridization (FISH) technique on a paraffin-embedded tissue block. It is designed to detect rearrangements involving the anaplastic lymphoma kinase (ALK) gene, particularly the EML4-ALK fusion gene.


ALK gene rearrangements are vital genetic alterations seen in several types of cancers, including non-small cell lung cancer (NSCLC). The most common of these is the EML4-ALK fusion gene, resulting from a chromosomal inversion. This fusion gene can produce an abnormal ALK protein that promotes uncontrolled cell growth, leading to the development of cancer.

  • Profile Name: ALK/EML4-FISH (Paraffin Block)
  • Sample Type: Tissue
  • Preparations Required: The test requires a tissue sample, usually obtained from a biopsy. No specific patient preparation is needed.
  • Report Time: 11 days

What is the ALK/EML4-FISH test?

The ALK/EML4-FISH test is a specialized diagnostic test that detects the presence of the EML4-ALK fusion gene, a significant genetic alteration seen in certain types of cancer, including non-small cell lung cancer (NSCLC).

Why is this test important?

This test is crucial in the diagnosis and management of NSCLC. If the EML4-ALK fusion gene is present, targeted therapy against the ALK protein can be used, which can greatly improve the patient's prognosis.

Home Sample Collection Process

1
Book your convenient slot
Book your convenient slot
2
Sample Collection by Phlebotomist
Sample Collection by Phlebotomist
3
Reporting of the sample at lab
Reporting of the sample at lab
4
Download Reports
Download Reports
Frequently Asked Questions

This test is typically recommended for patients with NSCLC, especially those who have not responded to traditional chemotherapy or who are known to have adenocarcinoma subtype.

The test requires a tissue sample, usually obtained from a biopsy. The sample is embedded in paraffin, and the FISH technique is used to identify the ALK gene rearrangements.

A positive result indicates the presence of the EML4-ALK fusion gene, suggesting that the patient's cancer may respond to ALK inhibitor therapy.

While FISH is a reliable and sensitive technique, it may not detect all ALK gene rearrangements. Additionally, the test's accuracy depends on the quality of the sample.

As the test uses a tissue sample, there are no dietary restrictions or requirements before the test.

The quality of the tissue sample and the technical aspects of the FISH procedure can affect the results.

No, this test requires a tissue sample that must be collected by a healthcare professional and processed in a laboratory.

Some discomfort might be experienced during the biopsy, but the testing process itself is not painful.

The primary risk is related to the biopsy procedure, such as infection or bleeding at the biopsy site.

If your test results are abnormal, your doctor will discuss treatment options with you, which may include targeted therapy against the ALK protein.

If your test results are abnormal, you should consult an oncologist or a pulmonologist.

While the EML4-ALK fusion gene is most commonly associated with non-small cell lung cancer, it has also been identified in other cancers, such as anaplastic large cell lymphoma and inflammatory myofibroblastic tumors. Therefore, this test could potentially be used to detect these types of cancers, but it is primarily used for diagnosing NSCLC.

If your test results are abnormal, your doctor may recommend additional diagnostic tests to further understand your condition, such as imaging tests (CT or PET scans) or other molecular diagnostic tests. Also, your doctor may recommend regular follow-ups to monitor the response to targeted therapy if that's the chosen treatment route.

Understanding your test results is crucial for making informed decisions about your health. The presence of the EML4-ALK fusion gene can open new treatment possibilities, like targeted therapies, that can potentially improve patient outcomes. Although the prospect of undergoing genetic testing may seem daunting, such tests are integral in modern medicine's aim to provide personalized treatment plans. Always consult your doctor if you have concerns or questions regarding your test or results.

ALK/EML4-FISH (Paraffin Block)
₹ 12000
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Locations Near You in Hyderabad
  • 4KM from Madhapur
  • 3KM from Banjara Hills
  • 1.9KM from Yusufguda
  • 3KM from Madhura Nagar
  • 5KM from Shaikpet