alk-eml4-fish

Patient Preparing : The test requires a tissue sample, usually obtained from a biopsy. No specific patient preparation is needed.

₹ 12000


ALK/EML4-FISH is a molecular diagnostic test using the Fluorescence In Situ Hybridization (FISH) technique on a paraffin-embedded tissue block. It is designed to detect rearrangements involving the anaplastic lymphoma kinase (ALK) gene, particularly the EML4-ALK fusion gene.

ALK gene rearrangements are vital genetic alterations seen in several types of cancers, including non-small cell lung cancer (NSCLC). The most common of these is the EML4-ALK fusion gene, resulting from a chromosomal inversion. This fusion gene can produce an abnormal ALK protein that promotes uncontrolled cell growth, leading to the development of cancer.

Test Name ALK/EML4-FISH (Paraffin Block)
Sample Type Tissue
Preparations Required The test requires a tissue sample, usually obtained from a biopsy. No specific patient preparation is needed.
Report Time 11 days
Price in Hyderabad ₹ 12000

What is the ALK/EML4-FISH test?

The ALK/EML4-FISH test is a specialized diagnostic test that detects the presence of the EML4-ALK fusion gene, a significant genetic alteration seen in certain types of cancer, including non-small cell lung cancer (NSCLC).

Why is this test important?

This test is crucial in the diagnosis and management of NSCLC. If the EML4-ALK fusion gene is present, targeted therapy against the ALK protein can be used, which can greatly improve the patient's prognosis.

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Who should get this test?

This test is typically recommended for patients with NSCLC, especially those who have not responded to traditional chemotherapy or who are known to have adenocarcinoma subtype.

How is the test performed?

The test requires a tissue sample, usually obtained from a biopsy. The sample is embedded in paraffin, and the FISH technique is used to identify the ALK gene rearrangements.

What do the test results mean?

A positive result indicates the presence of the EML4-ALK fusion gene, suggesting that the patient's cancer may respond to ALK inhibitor therapy.

What are the limitations of this test?

While FISH is a reliable and sensitive technique, it may not detect all ALK gene rearrangements. Additionally, the test's accuracy depends on the quality of the sample.

Can I eat or drink before the test?

As the test uses a tissue sample, there are no dietary restrictions or requirements before the test.

What factors can affect the test results?

The quality of the tissue sample and the technical aspects of the FISH procedure can affect the results.

Can this test be done at home?

No, this test requires a tissue sample that must be collected by a healthcare professional and processed in a laboratory.

Is the test painful?

Some discomfort might be experienced during the biopsy, but the testing process itself is not painful.

Is there any risk associated with this test?

The primary risk is related to the biopsy procedure, such as infection or bleeding at the biopsy site.

What happens if my test results are abnormal?

If your test results are abnormal, your doctor will discuss treatment options with you, which may include targeted therapy against the ALK protein.

Which doctor should I consult if my test results are abnormal?

If your test results are abnormal, you should consult an oncologist or a pulmonologist.

Can this test detect other types of cancer?

While the EML4-ALK fusion gene is most commonly associated with non-small cell lung cancer, it has also been identified in other cancers, such as anaplastic large cell lymphoma and inflammatory myofibroblastic tumors. Therefore, this test could potentially be used to detect these types of cancers, but it is primarily used for diagnosing NSCLC.

What other tests might I need if my results are abnormal?

If your test results are abnormal, your doctor may recommend additional diagnostic tests to further understand your condition, such as imaging tests (CT or PET scans) or other molecular diagnostic tests. Also, your doctor may recommend regular follow-ups to monitor the response to targeted therapy if that's the chosen treatment route.

Understanding your test results is crucial for making informed decisions about your health. The presence of the EML4-ALK fusion gene can open new treatment possibilities, like targeted therapies, that can potentially improve patient outcomes. Although the prospect of undergoing genetic testing may seem daunting, such tests are integral in modern medicine's aim to provide personalized treatment plans. Always consult your doctor if you have concerns or questions regarding your test or results.

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