The Neuroblastoma Profile test measures three specific biochemical markers in the urine - Vanillylmandelic Acid (VMA), 5-Hydroxyindoleacetic Acid (5-HIAA), and Homovanillic Acid (HVA). These substances are metabolites of certain neurotransmitters which are often found in increased levels in individuals with neuroblastoma and other tumors of the nervous system.
Neuroblastoma is a type of cancer that most often affects children under 5 years old. It starts in the adrenal glands but can spread to other parts of the body. The early symptoms of neuroblastoma are often vague and can be easily mistaken for other, less serious childhood conditions, making it challenging to diagnose.
The VMA, 5-HIAA, and HVA metabolites are produced when the body breaks down certain chemicals known as catecholamines, which include adrenaline and noradrenaline. These chemicals are produced in larger amounts by neuroblastoma tumors, leading to increased levels of these metabolites in the urine.
Note: Home Sample Collection is only for Pathology lab tests.
The test helps in the diagnosis and monitoring of neuroblastoma, a common type of cancer in children. By measuring the levels of VMA, 5-HIAA, and HVA in the urine, this test can aid in the detection of neuroblastoma and other related conditions.
The test requires a 24-hour urine collection. You'll be given a special container to collect your child's urine over a 24-hour period.
Your child should avoid foods high in serotonin and caffeinated beverages for 48 hours before the test. However, it's important to maintain a normal fluid intake 24 hours prior to collection.
The test itself is non-invasive and does not pose any risks. However, misinterpretation of results can lead to unnecessary worry or further testing. It's important to discuss the results and their implications with your healthcare provider.
The turnaround time for the test is typically 3-5 days.
Elevated levels of VMA, 5-HIAA, and HVA in the urine could suggest the presence of a neuroblastoma or other catecholamine-secreting tumors. However, these results must be interpreted in the context of your child's symptoms and clinical history.
The Neuroblastoma Profile test can suggest the presence of a neuroblastoma, but it is not definitive. If the results are abnormal, further diagnostic testing, such as imaging studies or a biopsy, may be needed to confirm the diagnosis.
If the test results are abnormal, your healthcare provider may recommend additional tests or referrals to specialists. It's important to remember that an abnormal result does not necessarily mean your child has a neuroblastoma or other serious condition.
While neuroblastoma most often affects children, especially those under the age of 5, this test can also be used in adults if a neuroblastoma or other catecholamine-secreting tumor is suspected.
The frequency of this test depends on your healthcare provider's recommendations, usually based on your child's symptoms, medical history, and previous test results.
A 24-hour urine test provides a more accurate measure of substances in the urine than a single 'spot' sample. It can better reflect the body's production of these substances over an entire day.
The urine collection should be stored in a refrigerator or a cool place during the collection period. After collection, it should be returned to the healthcare facility as soon as possible.
Yes, certain medications can affect the results of the test. It's important to inform your healthcare provider of any medications your child is currently taking.
If your child is diagnosed with neuroblastoma, your healthcare provider will discuss treatment options with you, which may include surgery, radiation therapy, chemotherapy, immunotherapy, or a combination of these.
Yes, this test can be used to monitor the effectiveness of treatment in neuroblastoma. A decrease in the levels of VMA, 5-HIAA, and HVA after treatment often suggests a good response to therapy.
VMA, 5-HIAA, and HVA are metabolites of catecholamines, which are neurotransmitters that are typically present in increased amounts in neuroblastoma tumors. Therefore, measuring these metabolites provides information about the presence and activity of these tumors.
Yes, your child should avoid foods high in serotonin, such as bananas, walnuts, tomatoes, avocados, and pineapples, for 48 hours prior to the test. Additionally, caffeinated beverages should also be avoided.
While this test is valuable in the diagnosis of neuroblastoma, it is not definitive on its own. Abnormal results can suggest the presence of a neuroblastoma, but additional testing, such as imaging studies and biopsies, are usually necessary to confirm the diagnosis.
The Neuroblastoma Profile test measures the levels of specific metabolites in the urine that are associated with neuroblastoma. However, it does not provide information about the specific type or stage of neuroblastoma. Further diagnostic procedures are needed for that information.
A 24-hour urine sample is necessary because the levels of the metabolites this test measures can fluctuate throughout the day. A 24-hour sample provides a more comprehensive look at the body's production of these metabolites.
Yes, this test can be used to monitor the progression of the disease. Regular testing can show whether the levels of VMA, 5-HIAA, and HVA are increasing or decreasing, which can provide information about how the disease is progressing and how well treatment is working.
While neuroblastoma is more common in children, especially those under the age of 5, this test can also be used in adults if there is a suspicion of a neuroblastoma or other catecholamine-secreting tumor.
Interpreting the results of this test should be done by a healthcare professional. They will consider the test results in conjunction with your child's symptoms, medical history, and the results of any other diagnostic tests.
After the test, your healthcare provider will review the results with you. If the test results suggest the presence of a neuroblastoma or other catecholamine-secreting tumor, they may recommend further testing to confirm the diagnosis and determine the most appropriate course of treatment.