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Lab Test

Multiple Sclerosis Profile - Comprehensive

Multiple Sclerosis Profile - Comprehensive

The Multiple Sclerosis (MS) Comprehensive Profile is a battery of tests that help in the diagnosis and monitoring of Multiple Sclerosis, a chronic disease that affects the central nervous system, particularly the brain, spinal cord, and optic nerves. This panel of tests includes the analysis of Albumin and Immunoglobulin G (IgG) in both cerebrospinal fluid (CSF) and serum, the Oligoclonal Band (OCB) test, the CSF Index, and the Myelin Associated Glycoprotein (MAG) antibody test.


  • Profile NameMultiple Sclerosis Profile - Comprehensive
  • Sample TypeCSF, Blood
  • Preparations RequiredNo fasting or specific preparation is required for this test. Ensure you are well hydrated and follow the healthcare provider's instructions.
  • Report Time5 days

Multiple Sclerosis is an autoimmune disorder where the body’s immune system mistakenly attacks the protective coverings of nerve fibers (myelin sheaths) in the central nervous system. This results in communication issues between the brain and the rest of the body. The cause of MS is still unknown, but it is believed to involve a combination of genetic and environmental factors. Early symptoms may include fatigue, difficulty walking, numbness or tingling, muscle weakness and spasms, poor bladder or bowel control, and problems with coordination and balance.

Home Sample Collection Process

1
Book your convenient slot
Book your convenient slot
2
Sample Collection by Phlebotomist
Sample Collection by Phlebotomist
3
Reporting of the sample at lab
Reporting of the sample at lab
4
Download Reports
Download Reports

Note: Home Sample Collection is only for Pathology lab tests.

Frequently Asked Questions

This test panel is crucial if you have symptoms suggestive of Multiple Sclerosis or if you've already been diagnosed and need monitoring. The panel aids in diagnosing MS, monitoring its progression, and gauging the effectiveness of treatment.

No, fasting is not necessary for the Multiple Sclerosis Profile - Comprehensive test. Please follow your healthcare provider's instructions.

The test requires both a cerebrospinal fluid (CSF) sample, obtained via lumbar puncture, and a blood sample.

The frequency of this test depends on your healthcare provider's advice, usually dependent on the presence of symptoms, your response to treatment, and disease progression.

Results of the MS Profile test can provide valuable information about the disease's presence and activity. Increased levels of Albumin or IgG in the CSF, the presence of Oligoclonal Bands, or a high CSF index can suggest active MS. Increased MAG antibodies can suggest damage to myelin sheaths. However, interpretation of these results should be done by a healthcare professional considering your symptoms, clinical history, and other diagnostic tests.

Factors such as infection, other autoimmune disorders, certain medications, and improper sample collection can affect the test results. It's crucial to discuss your complete medical history with your healthcare provider.

The CSF index is a calculated value that compares the ratio of IgG to Albumin in the CSF and serum. It can indicate whether the body is producing IgG within the central nervous system, a common occurrence in MS.

Oligoclonal Bands are proteins found in the CSF when there is inflammation in the central nervous system, such as in MS. Their presence supports a diagnosis of MS but can also be seen in other conditions like infections and inflammatory diseases.

While the test helps diagnose Multiple Sclerosis, it may also help diagnose other conditions affecting the central nervous system such as neuromyelitis optica, systemic lupus erythematosus, or certain infections.

While generally safe, lumbar puncture can sometimes lead to complications like headaches, infection, bleeding, or nerve damage. It's essential to discuss these risks with your healthcare provider before the procedure.

There's no cure for MS, but treatments can help manage symptoms, slow disease progression, and improve quality of life. These may include medications to modulate the immune system, physical therapy, and lifestyle changes like diet and exercise.

There's no known prevention for MS. If you have MS, avoiding triggers for flare-ups, such as infections, stress, and heat, can help manage the condition.

No, the test requires a lumbar puncture and blood draw, both of which should be performed in a healthcare setting.

The turn-around time for the test results is usually 3-5 days, but it can vary depending on the laboratory.

After the test, especially the lumbar puncture, it's essential to rest and avoid strenuous activities. Drink plenty of fluids to help prevent headaches. Follow your healthcare provider's specific instructions.

Generally, diet and lifestyle do not directly impact the results of this test. However, if you're dehydrated, it might be more difficult to draw blood or perform a lumbar puncture. Ensure you're well-hydrated before the test.

Before the lumbar puncture, your healthcare provider may ask you to stop taking certain medications that can increase the risk of bleeding. Make sure to discuss any medications you are currently taking, including over-the-counter drugs and supplements.

It's generally recommended that you arrange for someone to drive you home after a lumbar puncture as you might experience temporary side effects such as dizziness or headache.

Myelin Associated Glycoprotein (MAG) is a protein involved in maintaining the myelin sheath, the protective covering of nerve fibers. In MS, the immune system mistakenly attacks the myelin sheath. Testing for antibodies against MAG can help evaluate the extent of this immune response.

Lumbar puncture is the standard procedure for collecting a CSF sample. In some cases, a doctor may collect CSF from other locations, like the brain's ventricles, but these procedures are more invasive and typically reserved for specific situations.

Other tests that might be performed alongside this profile can include magnetic resonance imaging (MRI) to look for lesions in the brain and spinal cord, visual evoked potentials (VEP) to assess electrical activity in the brain, and a neurological exam to evaluate symptoms.

Yes, this test panel can help monitor disease activity and progression in individuals diagnosed with MS. It can also help evaluate the effectiveness of treatment.

If your test results are abnormal or unexpected, it's important to discuss them with your healthcare provider. They can help interpret the results in the context of your overall health, symptoms, and medical history.

This test can help identify increased disease activity, which may suggest a potential relapse. However, a relapse is typically diagnosed based on the appearance of new symptoms or the worsening of existing symptoms.

While MS is not directly inherited, genetic factors do play a role. Having a close relative with MS can increase your risk, but environmental factors and possibly viral infections are also thought to contribute.

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