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Lab Test

Fish- Lymphoma Panel Double Hit /triple Hit

Fluorescence In Situ Hybridization (FISH) is a powerful molecular cytogenetic technique employed to detect and visualize the presence or absence of specific DNA sequences on chromosomes. This test utilizes fluorescent probes that bind to only those parts of a chromosome where a high degree of sequence similarity exists. The FISH Lymphoma Panel for Double Hit / Triple Hit Lymphomas is designed to identify chromosomal changes that can lead to the overexpression of specific genes - c-Myc, Bcl2, Bcl6, and the IgH-cMyc fusion. These genetic changes are significant in the pathogenesis of certain aggressive lymphomas and their detection is essential for the appropriate diagnosis, prognosis, and management of these diseases

  • Profile Name Fluorescence In Situ Hybridization (FISH) - Lymphoma Panel Double Hit / Triple Hit
  • Sample Type Tissue
  • Preparations Required No special preparation is required before this test
  • Report Time 7 days

Double hit lymphomas (DHL) and triple hit lymphomas (THL) are subtypes of high-grade B-cell lymphomas characterized by concurrent rearrangements in the MYC, BCL2 and/or BCL6 genes. These lymphomas are rare, but their incidence is on the rise and they are associated with a particularly aggressive clinical course and poor prognosis. Importantly, the identification of these genetic changes necessitates a more aggressive treatment approach compared to standard diffuse large B-cell lymphoma (DLBCL).

FISH testing for double hit and triple hit lymphomas is vital in providing accurate diagnosis and guiding therapy decisions. The test helps identify patients who may require a more aggressive treatment regime and close follow-up due to the highly aggressive nature of these lymphomas.

Home Sample Collection Process

1
Book your convenient slot
Book your convenient slot
2
Sample Collection by Phlebotomist
Sample Collection by Phlebotomist
3
Reporting of the sample at lab
Reporting of the sample at lab
4
Download Reports
Download Reports

Note: Home Sample Collection is only for Pathology lab tests.

Frequently Asked Questions

A FISH test for Double Hit/Triple Hit Lymphomas is a specific procedure that uses fluorescent probes to detect chromosomal changes that can lead to the overexpression of the c-Myc, Bcl2, Bcl6 genes and the IgH-cMyc fusion. These genetic changes are significant in the development of certain aggressive lymphomas.

This test is crucial in the diagnosis, prognosis, and management of high-grade B-cell lymphomas. The presence of these gene rearrangements is associated with an aggressive disease course and poor prognosis, making early detection vital for treatment planning.

The test uses a blood or tissue sample. The sample is treated with fluorescent probes specific for the c-Myc, Bcl2, Bcl6 genes, and the IgH-cMyc fusion. The probes bind to these genes if present, and their fluorescence can be detected under a microscope.

The presence of these gene rearrangements indicates a likely diagnosis of Double Hit or Triple Hit Lymphoma. The presence of these rearrangements often signifies a more aggressive disease course and may require more intensive treatment.

If your test results are abnormal, you should consult with a hematologist or an oncologist. They specialize in blood diseases and cancers and can provide the appropriate treatment options.

There are minimal risks associated with the FISH test. If a blood sample is taken, there may be slight pain or bruising at the site of injection. If a tissue biopsy is taken, there may be slight discomfort during and after the procedure.

Testing is usually done when there are signs and symptoms suggestive of lymphoma, such as enlarged lymph nodes, fever, night sweats, weight loss, and fatigue. If you have been diagnosed with a B-cell lymphoma, this test may be done to further classify the lymphoma and guide treatment.

No, fasting is not required before the FISH test. You can eat and drink normally before the test.

The quality of the sample collected can affect the test results. Also, technical errors during the procedure can result in inaccurate results.

If your test results are abnormal, it's important to discuss the results with your doctor. They will interpret the results in the context of your overall health and symptoms and guide you on the next steps for treatment.

FISH testing for Double Hit and Triple Hit Lymphomas plays an essential role in the diagnostic workup for patients with suspected high-grade B-cell lymphomas. An understanding of these genetic changes can greatly impact treatment decisions and patient outcomes. As always, consult with your doctor for any questions or concerns you may have regarding this test

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