AML Leukemia Translocation Panel

This panel is performed to identify specific chromosomal alterations in the leukemia cells, which can provide information about the subtype of AML, prognosis, and potential treatment strategies.

The results of the panel will indicate whether any of the chromosomal alterations tested for are present in the leukemia cells. The presence of specific alterations can be associated with a more aggressive or more indolent course of the disease, and some may be targets for specific therapies.

A blood sample is drawn from a vein in the arm, and a bone marrow sample may also be collected through a procedure known as bone marrow aspiration.

For blood samples, there is minimal risk, such as slight pain or bruising at the puncture site. Bone marrow aspiration has higher risks including pain, bleeding, and infection.

No specific preparation is needed. However, it’s advisable to wear a short-sleeve shirt for ease of access for the blood draw and inform your doctor of any medications or supplements you are taking.

The results typically take between 7 to 10 days to be completed.

The results can be used to make more informed decisions regarding the treatment of AML, including the selection of targeted therapies that are effective against cells with specific chromosomal alterations.

If a chromosomal alteration is detected, the doctor will discuss the implications regarding the prognosis and available treatment options.

This test only looks for specific chromosomal alterations and will not detect other genetic mutations that may be present in the leukemia cells.

Certain chromosomal translocations are associated with different subtypes of AML and have prognostic significance. For example, t(15;17) is associated with a subtype called acute promyelocytic leukemia (APL), which often responds well to a combination of chemotherapy and a drug called all-trans retinoic acid.

No, this test requires a blood draw and possibly a bone marrow aspiration, which must be done in a clinical setting.

Yes, this test can be performed on individuals of all ages, including children, if they are suspected to have AML.

Other tests that might be performed include complete blood counts, bone marrow biopsy, and additional genetic testing.

Taking certain medications or supplements may affect the test results. It is important to inform your doctor of any medications or supplements you are taking.

You should consult a hematologist or oncologist who specializes in the treatment of blood cancers like AML.

This panel plays a significant role in the diagnosis, prognosis, and treatment selection for individuals with AML. By understanding the genetic makeup of the leukemia cells, doctors can develop a more personalized treatment plan. As a patient or caregiver, being well-informed about the significance of this test can help in making shared decisions about the treatment plan.