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Acute Leukemia Philadelphia Positive Panel

Acute Leukemia is a type of cancer affecting the blood and bone marrow. It is characterized by an abnormal proliferation of immature blood cells known as blasts. The Philadelphia chromosome is a specific genetic abnormality in chromosome 22 of leukemia cancer cells. The Acute Leukemia Philadelphia Positive Panel is an essential group of tests used to characterize acute leukemia and detect the presence of the Philadelphia chromosome, which is important in diagnosing and treating Chronic Myeloid Leukemia (CML) and sometimes Acute Lymphoblastic Leukemia (ALL).

Flow cytometry is a technique that allows for the analysis of multiple characteristics of cells in a sample, including the presence or absence of certain markers on the cell surface. Karyotyping is a test to examine chromosomes in a sample of cells. FISH (Fluorescence In Situ Hybridization) involves using fluorescent probes that bind to the DNA sequences, including the BCR-ABL gene fusion characteristic of the Philadelphia chromosome. If FISH is positive, Reflex RT-PCR (Reverse Transcription Polymerase Chain Reaction) for BCR-ABL is performed, which is a more sensitive and specific test for the gene fusion.

  • Profile Name Acute Leukemia Philadelphia Positive Panel (Flow Cytometry Acute Leukemia Characterization Panel + Karyotyping + FISH for BCR-ABL and Reflex RT-PCR for BCR-ABL - Qualitative if FISH is Positive)
  • Sample Type Blood or Bone Marrow
  • Preparations Required No specific preparation is required for this test. Fasting is not necessary, and no restrictions are placed on water consumption. However, it is advisable to follow any additional instructions provided by the doctor.
  • Report Time 12 days
Why is this panel important in diagnosing Acute Leukemia?

This panel is crucial as it combines various tests to provide detailed information about the genetic abnormalities present in leukemia cells. This information is vital for diagnosing, staging, and deciding on the best treatment approach.

What is the Philadelphia chromosome?

The Philadelphia chromosome is a shortened chromosome 22 found in the cancer cells of most patients with Chronic Myeloid Leukemia and some with Acute Lymphoblastic Leukemia. It results from a translocation between chromosomes 9 and 22.

Home Sample Collection Process

1
Book your convenient slot
Book your convenient slot
2
Sample Collection by Phlebotomist
Sample Collection by Phlebotomist
3
Reporting of the sample at lab
Reporting of the sample at lab
4
Download Reports
Download Reports

Note: Home Sample Collection is only for Pathology lab tests.

Frequently Asked Questions

Flow Cytometry is a technology that simultaneously analyzes multiple characteristics of single cells in a fluid stream. It is used in this panel to characterize the cell types present, including abnormal cells in leukemia.

FISH uses fluorescent probes specific for the BCR and ABL genes. If the Philadelphia chromosome is present, these probes will come close together and produce a unique fluorescence pattern.

RT-PCR is a highly sensitive method for detecting RNA that results from the BCR-ABL gene fusion. It is performed if FISH is positive to confirm the presence of the fusion gene.

If the Philadelphia chromosome is detected, it can have implications for prognosis and treatment decisions, including the use of targeted therapies such as tyrosine kinase inhibitors.

The sample is typically collected through a blood draw or a bone marrow aspiration procedure.

There are some risks associated with bone marrow aspiration, including pain, infection, bleeding, and bruising at the aspiration site.

If this panel shows an abnormal result, it is important to consult an oncologist who specializes in the treatment of blood cancers.

Coverage for this test depends on your insurance company and health care plan. It’s advisable to check with your insurance provider for specific information regarding coverage.

Yes, especially the RT-PCR component of the panel can be used to monitor the level of BCR-ABL fusion gene over time, reflecting the response to treatment.

Treatment options may include chemotherapy, targeted therapy with tyrosine kinase inhibitors, radiation therapy, or stem cell transplant.

The frequency of this test depends on various factors such as the stage of the disease, treatment plan, and doctor's recommendation.

Yes, factors such as a recent blood transfusion, infection, or medication can affect the results of this test.

The goal of treatment is often to achieve remission, where signs and symptoms of the cancer are reduced or disappear. Some patients may achieve long-term remission that can be considered a cure, but this is not always the case.

The Acute Leukemia Philadelphia Positive Panel is an essential component in the diagnosis and management of leukemia, especially those with the Philadelphia chromosome. This panel helps in providing comprehensive information that is invaluable for determining prognosis and guiding treatment decisions. Understanding the genetic makeup of leukemia is essential for targeted treatment. Patients are encouraged to communicate openly with their doctors, ask questions, and actively participate in decisions regarding their care.

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